Zhengyan Guo

chinese academy of medical sciences & peking union medical college

H指数:18

被引数:1,152

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Structure-Guided Discovery of Neuroprotective Kromycin-Type Macrolides from Streptomyces narbonensis sp.

纳博ensis属链霉菌结构指导的神经保护性克罗霉素型大环内酯类化合物的发现

Journal of Natural Products

IF3.6

2026-06-190

PRE

Characterization of UDP-Sugar 3-Dehydrase KsgR in the Biosynthesis of a Distinctive Multideoxy Diamino-Sugar Kasugamine of Kasugamycin

kasugamycin中独特多脱氧二氨基糖kasugamine生物合成中UDP-糖3-脱氢酶KsgR的表征

Journal of the American Chemical Society

IF15.6

2026-05-030

PRE

Identification of Glycosyltransferase AcbI in the Last-Step Biosynthesis of Herbicolin A for Improving Antifungal Activity

确定参与 Herbicolin A 最后一步生物合成中的糖基转移酶 AcbI 以提高其抗真菌活性

Organic Letters

IF5

2026-04-300

PRE

Synthesis, structural modification and characterization of indomethacin‑oxazol hybrids with enhanced gastrointestinal safety and anti‑inflammatory efficacy

合成、结构修饰及表征具有增强胃肠道安全性和抗炎活性的吲哚美辛-噁唑杂化物

Journal of Molecular Structure

IF4.7

2026-01-060

PRE

A novel extracellular mannan from Bacillus velezensis ameliorates metabolic-associated fatty liver disease by modulating gut microbiota in mice model

一株解淀粉芽孢杆菌产生的新型胞外甘露聚糖可通过调节肠道菌群改善小鼠模型中的代谢相关脂肪性肝病

Carbohydrate Polymers

IF12.5

2025-07-290

PRE

Design, synthesis and evaluation of antioxidant and anti-inflammatory activities of novel resveratrol derivatives as potential multifunctional drugs

新型白藜芦醇衍生物作为潜在多功能药物的设计、合成及抗氧化和抗炎活性评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-02-014

PRE

Transcriptomic analysis reveals the early body wall regeneration mechanism of the sea cucumber Holothuria leucospilota after artificially induced transverse fission

BMC GENOMICS

IF3.7

2023-12-122

OAAI

Insights into the biosynthesis of septacidin L-heptosamine moiety unveils a VOC family sugar epimerase

ACTA PHARMACEUTICA SINICA B

IF14.6

2023-02-014

OAAI

Construction and heterologous expression of the di-AFN A1 biosynthetic gene cluster in Streptomyces model strains

CHINESE JOURNAL OF NATURAL MEDICINES

IF4.9

2022-11-011

PRE

Identification of antimicrobial peptides from the human gut microbiome using deep learning

使用深度学习从人类肠道微生物组中鉴定抗菌肽

NATURE BIOTECHNOLOGY

IF41.7

2022-03-03205

PRE

Initiating polyketide biosynthesis by on-line methyl esterification

NATURE COMMUNICATIONS

IF15.7

2021-07-2313

OAAI

Discovery of Brominated Alboflavusins With Anti-MRSA Activities

FRONTIERS IN MICROBIOLOGY

IF4.5

2021-02-164

OAAI

Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses

NATURAL PRODUCT REPORTS

IF10.6

2021-01-0112

PREAI

Deciphering the Biosynthesis of TDP-β-L-oleandrose in Avermectin

JOURNAL OF NATURAL PRODUCTS

IF3.6

2020-09-248

PREAI

Characterization of SepE and SepF for the N6-Glycosylated Adenine Structure Formation in Septacidin Biosynthesis

SepE和SepF在Septacidin生物合成中N6-Glycosylated腺嘌呤结构形成的表征

ORGANIC LETTERS

IF5

2020-06-2110

PREAI

Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage

ORGANIC LETTERS

IF5

2020-01-097

PREAI

Activation of paulomycin production by exogenous γ-butyrolactone signaling molecules in Streptomyces albidoflavus J1074

albidoflavus J1074中外源 γ-丁内酯信号分子激活paulomycin生产

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

IF4.3

2020-01-0317

PREAI

An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters

NATURE COMMUNICATIONS

IF15.7

2019-08-1439

OAAI

Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2018-12-0531

PREAI

Hexaricins, Pradimicin-like Polyketides from a Marine Sediment-Derived Streptosporangium sp and Their Antioxidant Effects

JOURNAL OF NATURAL PRODUCTS

IF3.6

2018-09-0425

PREAI

Zhengyan Guo

个人简介

教育背景

工作经历

荣誉奖项

研究方向