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A

Angela Oh

roche holding usa
H指数:17
被引数:1,721

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Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2)
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-08-244
OA
Zeng, Mingshuo; Grandner, Jessica M.; Bryan, Marian C.; Verma, Vishal; Larouche-Gauthier, Robin; Leclerc, Jean-Philippe; Zhao, Liang; Haghshenas, Pouyan; Aubert-Nicol, Samuel; Yadav, Arun; Ashley, Melissa; Chen, Jacob Z.; Durk, Matthew; Samy, Karen E.; Nespi, Marika; Levy, Elizabeth; Merrick, Karl; Moffat, John G.; Murray, Jeremy; Oh, Angela; Orr, Christine; Segal, Ehud; Sims, Jessica; Sneeringer, Christopher; Prangley, Madeleine; Vartanian, Steffan; Magnuson, Steven; Parr, Brendan T.
Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

通过抑制脂多糖转运蛋白MsbA破坏革兰氏阴性细菌外膜生物合成

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2018-11-0153
OAAI
Alexander, Mary Kate; Miu, Anh; Oh, Angela; Reichelt, Mike; Ho, Hoangdung; Chalouni, Cecile; Labadie, Sharada; Wang, Lan; Liang, Jun; Nickerson, Nicholas N.; Hu, Huiyong; Yu, Lan; Du, Miaofen; Yang, Donghong; Park, Summer; Kim, Janice; Xu, Min; Sellers, Benjamin D.; Purkey, Hans E.; Skelton, Nicholas J.; Koehler, Michael F. T.; Payandeh, Tian; Verma, Vishal; Xu, Yiming; Koth, Christopher M.; Nishiyama, Mireille
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-05-2455
PREAI
Rudolph, Joachim; Murray, Lesley J.; Ndubaku, Chudi O.; O'Brien, Thomas; Blackwood, Elizabeth; Wang, Weiru; Aliagas, Ignacio; Gazzard, Lewis; Crawford, James J.; Drobnick, Joy; Lee, Wendy; Zhao, Xianrui; Hoeflich, Klaus P.; Favor, David A.; Dong, Ping; Zhang, Haiming; Heise, Christopher E.; Oh, Angela; Ong, Christy C.; La, Hank; Chakravarty, Paroma; Chan, Connie; Jakubiak, Diana; Epler, Jennifer; Ramaswamy, Sreemathy; Vega, Roxanne; Cain, Gary; Diaz, Dolores; Zhong, Yu
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2015-11-0372
OAAI
Ndubaku, Chudi O.; Crawford, James J.; Drobnick, Joy; Aliagas, Ignacio; Campbell, David; Dong, Ping; Dornan, Laura M.; Duron, Sergio; Epler, Jennifer; Gazzard, Lewis; Heise, Christopher E.; Hoeflich, Klaus P.; Jakubiak, Diana; La, Hank; Lee, Wendy; Lin, Baiwei; Lyssikatos, Joseph P.; Maksimoska, Jasna; Marmorstein, Ronen; Murray, Lesley J.; O'Brien, Thomas; Oh, Angela; Ramaswamy, Sreemathy; Wang, Weiru; Zhao, Xianrui; Zhong, Yu; Blackwood, Elizabeth; Rudolph, Joachim
Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-02-0465
PREAI
Staben, Steven T.; Feng, Jianwen A.; Lyle, Karen; Belvin, Marcia; Boggs, Jason; Burch, Jason D.; Chua, Ching-ching; Cui, Haifeng; DiPasquale, Antonio G.; Friedman, Lori S.; Heise, Christopher; Koeppen, Hartmut; Kotey, Adrian; Mintzer, Robert; Oh, Angela; Roberts, David Allen; Rouge, Lionel; Rudolph, Joachim; Tam, Christine; Wang, Weiru; Xiao, Yisong; Young, Amy; Zhang, Yamin; Hoeflich, Klaus P.
Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins
PLOS PATHOGENS
IF4.9
2013-10-1070
OAAI
Hazenbos, Wouter L. W.; Kajihara, Kimberly K.; Vandlen, Richard; Morisaki, J. Hiroshi; Lehar, Sophie M.; Kwakkenbos, Mark J.; Beaumont, Tim; Bakker, Arjen Q.; Phung, Qui; Swem, Lee R.; Ramakrishnan, Satish; Kim, Janice; Xu, Min; Shah, Ishita M.; Diep, Binh An; Sai, Tao; Sebrell, Andrew; Khalfin, Yana; Oh, Angela; Koth, Chris; Lin, S. Jack; Lee, Byoung-Chul; Strandh, Magnus; Koefoed, Klaus; Andersen, Peter S.; Spits, Hergen; Brown, Eric J.; Tan, Man-Wah; Mariathasan, Sanjeev
Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2013-07-3184
PREAI
Zheng, Xiaozhang; Bauer, Paul; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H.; Han, Bingsong; Ho, Yen-Ching; Kley, Nikolai; Lin, Jian; Reynolds, Dominic J.; Sharma, Geeta; Smith, Chase C.; Wang, Zhongguo; Dragovich, Peter S.; Gunzner-Toste, Janet; Liederer, Bianca M.; Ly, Justin; O'Brien, Thomas; Oh, Angela; Wang, Leslie; Wang, Weiru; Xiao, Yang; Zak, Mark; Zhao, Guiling; Yuen, Po-wai; Bair, Kenneth W.
Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2013-06-1369
PREAI
Zheng, Xiaozhang; Bauer, Paul; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H.; Han, Bingsong; Ho, Yen-Ching; Kley, Nikolai; Lin, Jian; Reynolds, Dominic J.; Sharma, Geeta; Smith, Chase C.; Wang, Zhongguo; Dragovich, Peter S.; Oh, Angela; Wang, Weiru; Zak, Mark; Gunzner-Toste, Janet; Zhao, Guiling; Yuen, Po-wai; Bair, Kenneth W.
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

小分子配体与Ras中不同的口袋结合并抑制SOS介导的核苷酸交换活性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2012-03-19612
OAAI
Maurer, Till; Garrenton, Lindsay S.; Oha, Angela; Pitts, Keith; Anderson, Daniel J.; Skelton, Nicholas J.; Fauber, Benjamin P.; Pan, Borlan; Malek, Shiva; Stokoe, David; Ludlam, Mary J. C.; Bowman, Krista K.; Wu, Jiansheng; Giannetti, Anthony M.; Starovasnik, Melissa A.; Mellman, Ira; Jackson, Peter K.; Rudolph, Joachim; Wang, Weiru; Fang, Guowei

研究方向

暂未获取到该数据
W
Weiru Wang
H 指数:42论文数:168被引数:1.0万
J
Joachim Rudolph
H 指数:37论文数:169被引数:4,895
T
Thomas O’Brien
H 指数:42论文数:104被引数:6,566
K
Klaus P. Hoeflich
H 指数:47论文数:267被引数:1.1万
N
Nicholas J. Skelton
H 指数:47论文数:167被引数:8,820
C
Christopher E. Heise
H 指数:29论文数:86被引数:5,569
M
Min Xu
H 指数:36论文数:111被引数:5,534
S
Shiva Malek
H 指数:36论文数:216被引数:7,389
I
Ira Mellman
H 指数:127论文数:461被引数:8.4万
J
Janice Kim
H 指数:33论文数:135被引数:7,025