Heekuk Park

Harvard University

H指数:22

被引数:2,225

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2-Amino-3; 4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X

2-氨基-3,4-二氢喹唑啉类化合物通过靶向血红素X展示显著的抗疟疾活性

ACS Infectious Diseases

IF3.8

2026-08-140

PRE

随着时间推移，回肠微生物组失调趋势作为肠道移植排斥风险的早期评估指标

American Journal of Transplantation

IF8.2

2026-07-220

OAAI

Vancomycin-resistant Enterococcus often spreads from hospitalized patients into the local environment and less often spreads from the environment into patients

万古霉素耐药肠球菌常从住院患者传播到当地环境，且较少从环境传播至患者

The Journal of Infectious Diseases

IF0

2026-07-150

PRE

Identification of genetic markers of quinine partial resistance in Plasmodium falciparum

鉴定恶性疟原虫中奎宁部分耐药性的遗传标记

Nature Microbiology

IF19.4

2026-07-060

OAAI

Mariko Kanai; Sachel Mok; Tomas Yeo; Melanie J. Shears; Jin H. Jeon; Sunil K. Narwal; Leila S. Ross; Kharizta Wiradiputri; Meseret T. Haile; Abhai K. Tripathi; Godfree Mlambo; Jonathan Kim; Eva Gil-Iturbe; Heekuk Park; Tolla Ndiaye; John Okombo; Kurt E. Ward; Felix D. Rozenberg; Kate J. Fairhurst; Sydney M. Gavula; Talia S. Bloxham; Jessica L. Bridgford; Tanaya Sheth; Manuel Llinás; Marcus C. S. Lee; Jennifer L. Small-Saunders; Filippo Mancia; Matthias Quick; Anne-Catrin Uhlemann; Photini Sinnis; David Armand Fidock

Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site

恶性疟原虫HSP90抑制剂表现出差异性耐药性，尽管具有共同的ATP结合位点

Cell Reports

IF6.9

2026-07-010

PRE

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489与哌喹之间的交叉高敏性中和了PfCRT介导的药物外排和恶性疟原虫抗性

Nature Communications

IF15.7

2026-04-010

OAAI

John Okombo; Tolla Ndiaye; Tarrick Qahash; Igor M. R. Moura; Eva Gil-Iturbe; Laura M. Hagenah; Jessica L. Bridgford; Vinicius Bonatto; Kurt E. Ward; Tomas Yeo; Sunil K. Narwal; Lily V. Orta; Isla Anderson; Satish K. Dhingra; Charisse Flerida A. Pasaje; Heekuk Park; Jonathan Kim; Rafael V. C. Guido; Maria Belén Jiménez-Diaz; Iñigo Angulo-Barturen; Jacquin C. Niles; Filippo Mancia; Anne-Catrin Uhlemann; Sachel Mok; Matthias Quick; Elizabeth A. Winzeler; Didier Leroy; Manuel Llinás; Vandana Thathy; David A. Fidock

Urobiota analysis and genomewide association study in pediatric recurrent urinary tract infections and vesicoureteral reflux

尿微生物组分析与全基因组关联研究在儿科复发性尿路感染和膀胱输尿管反流中的应用

JCI Insight

IF6.1

2026-01-231

Gut Colonization With Vancomycin-Resistant Enterococcus Shapes the Gut Microbiome in the Intensive Care Unit

使用万古霉素耐药肠球菌进行肠道定植塑造了重症监护病房的肠道微生物组

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2025-04-160

PRE

Processing-bias correction with DEBIAS-M improves cross-study generalization of microbiome-based prediction models

使用DEBIAS-M进行加工偏差校正可提高基于微生物组的预测模型在跨研究中的泛化能力。

NATURE MICROBIOLOGY

IF19.4

2025-03-271

A phase 2 randomized, placebo-controlled trial of inulin for the prevention of gut pathogen colonization and infection among patients admitted to the intensive care unit for sepsis

一项关于菊粉预防脓毒症患者入住重症监护室期间肠道病原体定植和感染的随机、安慰剂对照Ⅱ期临床试验

CRITICAL CARE

IF9.3

2025-01-132

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission

SCIENCE ADVANCES

IF12.5

2024-12-060

OAAI

Gomez-Gonzalez, Paula-Josefina; Gupta, Antima; Drought, Laura G.; Patel, Avnish; Okombo, John; van der Watt, Mariette; Walker-Gray, Ryan; Schindler, Kyra A.; Burkhard, Anna Y.; Yeo, Tomas; Narwal, Sunil K.; Bloxham, Talia S.; Flueck, Christian; Walker, Eloise M.; Rey, Joshua A.; Fairhurst, Kate J.; Reader, Janette; Park, Heekuk; Pollard, Harry G.; Stewart, Lindsay B.; Brandner-Garrod, Luke; Kristan, Mojca; Sterk, Geert-Jan; van Nuland, Youri M.; Manko, Emilia; van Schalkwyk, Donelly A.; Zheng, Yang; Leurs, Rob; Dechering, Koen J.; Aguiar, Anna Caroline C.; Guido, Rafael V. C.; Pereira, Dhelio B.; Tumwebaze, Patrick K.; Nosbya, Samuel L.; Rosenthal, Philip J.; Cooper, Roland A.; Palmer, Mike; Parkinson, Tanya; Burrows, Jeremy N.; Uhlemann, Anne-Catrin; Birkholtz, Lyn-Marie; Small-Saunders, Jennifer L.; Duffy, James; Fidock, David A.; Brown, Alan; Gardner, Mark; Baker, David A.

Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

针对线粒体蛋白，细胞色素b的环丙基甲酰胺的抗疟活性的探索和表征

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-12-010

OAAI

Awalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Ramesh, Saishyam; Fairhurst, Kate J.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Maity, Bikash Chandra; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T.; Delves, Michael J.; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A.; Papenfuss, Anthony T.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Maier, Alexander G.; van Dooren, Giel G.; Baud, Delphine; Brand, Stephen; Fidock, David A.; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.

An evaluation of in utero polycyclic aromatic hydrocarbon exposure on the neonatal meconium microbiome

ENVIRONMENTAL RESEARCH

IF7.7

2024-12-010

PRE

Impact of D-allulose consumption on Enteric pathogens in human gut Microbiota: A randomized controlled trial study

JOURNAL OF FUNCTIONAL FOODS

IF4

2024-11-010

OAAI

Genomic epidemiology of carbapenem-resistant Enterobacterales at a New York City hospital over a 10-year period reveals complex plasmid-clone dynamics and evidence for frequent horizontal transfer of blaKPC

GENOME RESEARCH