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J

John Okombo

Harvard University
H指数:24
被引数:1,727

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Identification of genetic markers of quinine partial resistance in Plasmodium falciparum

鉴定恶性疟原虫中奎宁部分耐药性的遗传标记

Nature Microbiology
IF19.4
2026-07-060
OAAI
Mariko Kanai; Sachel Mok; Tomas Yeo; Melanie J. Shears; Jin H. Jeon; Sunil K. Narwal; Leila S. Ross; Kharizta Wiradiputri; Meseret T. Haile; Abhai K. Tripathi; Godfree Mlambo; Jonathan Kim; Eva Gil-Iturbe; Heekuk Park; Tolla Ndiaye; John Okombo; Kurt E. Ward; Felix D. Rozenberg; Kate J. Fairhurst; Sydney M. Gavula; Talia S. Bloxham; Jessica L. Bridgford; Tanaya Sheth; Manuel Llinás; Marcus C. S. Lee; Jennifer L. Small-Saunders; Filippo Mancia; Matthias Quick; Anne-Catrin Uhlemann; Photini Sinnis; David Armand Fidock
Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site

恶性疟原虫HSP90抑制剂表现出差异性耐药性，尽管具有共同的ATP结合位点

Cell Reports
IF6.9
2026-07-010
PRE
Ko, Fu-Hsuan; Lukens, Amanda K.; de Souza, Mariana Laureano; Foy, Alex; Hsiao, Jason; Ndiaye, Tolla; Okombo, John; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Boonyalai, Nonlawat; Kumpornsin, Krittikorn; Girling, Gareth; Pasaje, Charisse; Godoy, Luiz; Kapoor, Priyan; Durst, Gregory L.; Ottilie, Sabine; Chatterjee, Arnab; Niles, Jacquin; Lee, Marcus; Fidock, David A.; Wirth, Dyann F.; Winzeler, Elizabeth A.
Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489与哌喹之间的交叉高敏性中和了PfCRT介导的药物外排和恶性疟原虫抗性

Nature Communications
IF15.7
2026-04-010
OAAI
John Okombo; Tolla Ndiaye; Tarrick Qahash; Igor M. R. Moura; Eva Gil-Iturbe; Laura M. Hagenah; Jessica L. Bridgford; Vinicius Bonatto; Kurt E. Ward; Tomas Yeo; Sunil K. Narwal; Lily V. Orta; Isla Anderson; Satish K. Dhingra; Charisse Flerida A. Pasaje; Heekuk Park; Jonathan Kim; Rafael V. C. Guido; Maria Belén Jiménez-Diaz; Iñigo Angulo-Barturen; Jacquin C. Niles; Filippo Mancia; Anne-Catrin Uhlemann; Sachel Mok; Matthias Quick; Elizabeth A. Winzeler; Didier Leroy; Manuel Llinás; Vandana Thathy; David A. Fidock
Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Plasmodium falciparum蛋白激酶6和血红素晶体的形成被一种具有抗疟疾活性的II型人源激酶抑制剂所抑制

Cell Chemical Biology
IF7.2
2025-07-070
PRE
Flore Nardella; Tiantian Jiang; Lushun Wang; Monica J. Bohmer; Subhoja Chakraborty; John Okombo; Jaeson Calla; Tatiane Macedo Silva; Samuel Pazicky; Jianwei Che; Jin Jeon; Evie Vincent; Nonlawat Boonyalai; Rachael Coyle; Mairi J. Buchanan; Samuel Schaefer; Daisy Chen; Amaan Khan; Emily Mayville; Mariana Laureano De Souza; Mayland Treat; Jordan Charlton; Patrick K. Tumwebaze; Seth Tjia; Lukas Montejo; Karen Cover; Philip J. Rosenthal; Roland A. Cooper; Zbynek Bozdech; Marcus C.S. Lee; Ratna Chakrabarti; Sanjay A. Desai; David A. Fidock; Jinhua Wang; Nathanael S. Gray; Elizabeth A. Winzeler; Debopam Chakrabarti
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission
SCIENCE ADVANCES
IF12.5
2024-12-060
OAAI
Gomez-Gonzalez, Paula-Josefina; Gupta, Antima; Drought, Laura G.; Patel, Avnish; Okombo, John; van der Watt, Mariette; Walker-Gray, Ryan; Schindler, Kyra A.; Burkhard, Anna Y.; Yeo, Tomas; Narwal, Sunil K.; Bloxham, Talia S.; Flueck, Christian; Walker, Eloise M.; Rey, Joshua A.; Fairhurst, Kate J.; Reader, Janette; Park, Heekuk; Pollard, Harry G.; Stewart, Lindsay B.; Brandner-Garrod, Luke; Kristan, Mojca; Sterk, Geert-Jan; van Nuland, Youri M.; Manko, Emilia; van Schalkwyk, Donelly A.; Zheng, Yang; Leurs, Rob; Dechering, Koen J.; Aguiar, Anna Caroline C.; Guido, Rafael V. C.; Pereira, Dhelio B.; Tumwebaze, Patrick K.; Nosbya, Samuel L.; Rosenthal, Philip J.; Cooper, Roland A.; Palmer, Mike; Parkinson, Tanya; Burrows, Jeremy N.; Uhlemann, Anne-Catrin; Birkholtz, Lyn-Marie; Small-Saunders, Jennifer L.; Duffy, James; Fidock, David A.; Brown, Alan; Gardner, Mark; Baker, David A.
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

一种具有多阶段抗疟活性且与PfCRT和PfMDR1突变体缺乏交叉抗性的新型4-氨基喹啉化学型

PLOS PATHOGENS
IF4.9
2024-10-290
OAAI
Ferreira, Leticia Tiburcio; Cassiano, Gustavo Capatti; Alvarez, Luis Carlos Salazar; Okombo, John; Calit, Juliana; Fontinha, Diana; Gil-Iturbe, Eva; Coyle, Rachael; Andrade, Carolina Horta; Sunnerhagen, Per; Bargieri, Daniel Youssef; Prudencio, Miguel; Quick, Matthias; Cravo, Pedro V.; Lee, Marcus C. S.; Fidock, David A.; Costa, Fabio Trindade Maranhao
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology
MBIO
IF4.7
2024-01-163
OAAI
Hagenah, Laura M.; Dhingra, Satish K.; Small-Saunders, Jennifer L.; Qahash, Tarrick; Willems, Andreas; Schindler, Kyra A.; Rangel, Gabriel W.; Gil-Iturbe, Eva; Kim, Jonathan; Akhundova, Emiliya; Yeo, Tomas; Okombo, John; Mancia, Filippo; Quick, Matthias; Roepe, Paul D.; Llinas, Manuel; Fidock, David A.
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38
BRITISH JOURNAL OF PHARMACOLOGY
IF7.7
2023-06-108
OAAI
Armstrong, Jane F.; Campo, Brice; Alexander, Stephen P. H.; Arendse, Lauren B.; Cheng, Xiu; Davenport, Anthony P.; Faccenda, Elena; Fidock, David A.; Godinez-Macias, Karla P.; Harding, Simon D.; Kato, Nobutaka; Lee, Marcus C. S.; Luth, Madeline R.; Mazitschek, Ralph; Mittal, Nimisha; Niles, Jacquin C.; Okombo, John; Ottilie, Sabine; Pasaje, Charisse Flerida A.; Probst, Alexandra S.; Rawat, Mukul; Rocamora, Frances; Sakata-Kato, Tomoyo; Southan, Christopher; Spedding, Michael; Tye, Mark A.; Yang, Tuo; Zhao, Na; Davies, Jamie A.
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
NATURE COMMUNICATIONS
IF15.7
2023-05-2715
OAAI
Kumpornsin, Krittikorn; Kochakarn, Theerarat; Yeo, Tomas; Okombo, John; Luth, Madeline R.; Hoshizaki, Johanna; Rawat, Mukul; Pearson, Richard D.; Schindler, Kyra A.; Mok, Sachel; Park, Heekuk; Uhlemann, Anne-Catrin; Jana, Gouranga P.; Maity, Bikash C.; Laleu, Benoit; Chenu, Elodie; Duffy, James; Moliner Cubel, Sonia; Franco, Virginia; Gomez-Lorenzo, Maria G.; Gamo, Francisco Javier; Winzeler, Elizabeth A.; Fidock, David A.; Chookajorn, Thanat; Lee, Marcus C. S.
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-03-0811
OA
Istvan, Eva S.; Guerra, Francisco; Abraham, Matthew; Huang, Kuo-Sen; Rocamora, Frances; Zhao, Haoshuang; Xu, Lan; Pasaje, Charisse; Kumpornsin, Krittikorn; Luth, Madeline R.; Cui, Haissi; Yang, Tuo; Diaz, Sara Palomo; Gomez-Lorenzo, Maria G.; Qahash, Tarrick; Mittal, Nimisha; Ottilie, Sabine; Niles, Jacquin; Lee, Marcus C. S.; Llinas, Manue; Kato, Nobutaka; Okombo, John; Fidock, David A.; Schimmel, Paul; Gamo, Francisco Javier; Goldberg, Daniel E.; Winzeler, Elizabeth A.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
CELL CHEMICAL BIOLOGY
IF7.2
2022-05-0118
OAAI
Murithi, James M.; Deni, Ioanna; Pasaje, Charisse Flerida A.; Okombo, John; Bridgford, Jessica L.; Gnadig, Nina F.; Edwards, Rachel L.; Yeo, Tomas; Mok, Sachel; Burkhard, Anna Y.; Coburn-Flynn, Olivia; Istvan, Eva S.; Sakata-Kato, Tomoyo; Gomez-Lorenzo, Maria G.; Cowell, Annie N.; Wicht, Kathryn J.; Le Manach, Claire; Kalantarov, Gavreel F.; Dey, Sumanta; Duffey, Maelle; Laleu, Benoit; Lukens, Amanda K.; Ottilie, Sabine; Vanaerschot, Manu; Trakht, Ilya N.; Gamo, Francisco-Javier; Wirth, Dyann F.; Goldberg, Daniel E.; John, Audrey R. Odom; Chibale, Kelly; Winzeler, Elizabeth A.; Niles, Jacquin C.; Fidock, David A.
Prioritization of Molecular Targets for Antimalarial Drug Discovery

优先考虑抗疟药物发现的分子靶标

ACS INFECTIOUS DISEASES
IF3.8
2021-09-1551
OAAI
Forte, Barbara; Ottilie, Sabine; Plater, Andrew; Campo, Brice; Dechering, Koen J.; Javier Gamo, Francisco; Goldberg, Daniel E.; Istvan, Eva S.; Lee, Marcus; Lukens, Amanda K.; McNamara, Case W.; Niles, Jacquin C.; Okombo, John; Pasaje, Charisse Flerida A.; Siegel, Miles G.; Wirth, Dyann; Wyllie, Susan; Fidock, David A.; Baragana, Beatriz; Winzeler, Elizabeth A.; Gilbert, Ian H.
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-02-2315
OA
Lawong, Aloysus; Gahalawat, Suraksha; Okombo, John; Striepen, Josefine; Yeo, Tomas; Mok, Sachel; Deni, Ioanna; Bridgford, Jessica L.; Niederstrasser, Hanspeter; Zhou, Anwu; Posner, Bruce; Wittlin, Sergio; Javier Gamo, Francisco; Crespo, Benigno; Churchyard, Alisje; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth; Laleu, Benoit; Palmer, Michael J.; Charman, Susan A.; Fidock, David A.; Ready, Joseph M.; Phillips, Margaret A.
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model (vol 63, pg 13013, 2020)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-01-280
PREAI
Horatscheck, Andre; Andrijevic, Ana; Nchinda, Aloysius T.; Le Manach, Claire; Paquet, Tanya; Khonde, Lutete Peguy; Dam, Jean; Pawar, Kailash; Taylor, Dale; Lawrence, Nina; Brunschwig, Christel; Gibhard, Liezl; Njoroge, Mathew; Reader, Janette; van der Watt, Mariette; Wicht, Kathryn; de Sousa, Ana Carolina C.; Okombo, John; Maepa, Keletso; Egan, Timothy J.; Birkholtz, Lyn-Marie; Basarab, Gregory S.; Wittlin, Sergio; Fish, Paul V.; Street, Leslie J.; Duffy, James; Chibale, Kelly
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-10-2613
OAAI
Horatscheck, Andre; Andrijevic, Ana; Nchinda, Aloysius T.; Le Manach, Claire; Paquet, Tanya; Khonde, Lutete Peguy; Dam, Jean; Pawar, Kailash; Taylor, Dale; Lawrence, Nina; Brunschwig, Christel; Gibhard, Liezl; Njoroge, Mathew; Reader, Janette; van der Watt, Mariette; Wicht, Kathryn; de Sousa, Ana Carolina C.; Okombo, John; Maepa, Keletso; Egan, Timothy J.; Birkholtz, Lyn-Marie; Basarab, Gregory S.; Wittlin, Sergio; Fish, Paul, V; Street, Leslie J.; Duffy, James; Chibale, Kelly

研究方向

暂未获取到该数据
D
David A. Fidock
H 指数:95论文数:427被引数:3.3万
K
Kelly Chibale
H 指数:42论文数:281被引数:6,313
T
Tomas Yeo
H 指数:23论文数:77被引数:2,109
T
Timothy J. Egan
H 指数:52论文数:272被引数:9,106
E
Elizabeth A. Winzeler
H 指数:83论文数:356被引数:3.6万
A
Alexis Nzila
H 指数:42论文数:131被引数:6,451
S
Sachel Mok
H 指数:31论文数:73被引数:4,929
S
Sergio Wittlin
H 指数:49论文数:250被引数:8,876
M
Mathew Njoroge
H 指数:21论文数:76被引数:1,351
L
Lee M
H 指数:48论文数:356被引数:1.0万