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Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity 设计的从羧酸酯酶Notum活性的共价抑制剂到非共价抑制剂的转换 Atkinson, Benjamin N.; Willis, Nicky J.; Zhao, Yuguang; Patel, Chandni; Frew, Sarah; Costelloe, Kathryn; Magno, Lorenza; Svensson, Fredrik; Jones, E. Yvonne; Fish, Paul V. 分享 收藏
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit Willis, Nicky J.; Mahy, William; Sipthorp, James; Zhao, Yuguang; Woodward, Hannah L.; Atkinson, Benjamin N.; Bayle, Elliott D.; Svensson, Fredrik; Frew, Sarah; Jeganathan, Fiona; Monaghan, Amy; Benvegnu, Stefano; Jolly, Sarah; Vecchia, Luca; Ruza, Reinis R.; Kjaer, Svend; Howell, Steven; Snijders, Ambrosius P.; Bictash, Magda; Salinas, Patricia C.; Vincent, Jean-Paul; Jones, E. Yvonne; Whiting, Paul; Fish, Paul, V 分享 收藏
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Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity Steadman, David; Atkinson, Benjamin N.; Zhao, Yuguang; Willis, Nicky J.; Frew, Sarah; Monaghan, Amy; Patel, Chandni; Armstrong, Emma; Costelloe, Kathryn; Magno, Lorenza; Bictash, Magda; Jones, E. Yvonne; Fish, Paul, V; Svensson, Fredrik 分享 收藏
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Structural Insights into Notum Covalent Inhibition Zhao, Yuguang; Svensson, Fredrik; Steadman, David; Frew, Sarah; Monaghan, Amy; Bictash, Magda; Moreira, Tiago; Chalk, Rod; Lu, Weixian; Fish, Paul, V; Jones, E. Yvonne 分享 收藏
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Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling Bayle, Elliott D.; Svensson, Fredrik; Atkinson, Benjamin N.; Steadman, David; Willis, Nicky J.; Woodward, Hannah L.; Whiting, Paul; Vincent, Jean-Paul; Fish, Paul, V 分享 收藏
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5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit Mahy, William; Willis, Nicky J.; Zhao, Yuguang; Woodward, Hannah L.; Svensson, Fredrik; Sipthorp, James; Vecchia, Luca; Ruza, Reinis R.; Hillier, James; Kjaer, Svend; Frew, Sarah; Monaghan, Amy; Bictash, Magda; Salinas, Patricia C.; Whiting, Paul; Vincent, Jean-Paul; Jones, E. Yvonne; Fish, Paul, V 分享 收藏
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei Alghamdi, Ali H.; Munday, Jane C.; Campagnaro, Gustavo Daniel; Gurvic, Dominik; Svensson, Fredrik; Okpara, Chinyere E.; Kumar, Arvind; Quintana, Juan; Abril, Maria Esther Martin; Milic, Patrik; Watson, Laura; Paape, Daniel; Settimo, Luca; Dimitriou, Anna; Wielinska, Joanna; Smart, Graeme; Anderson, Laura F.; Woodley, Christopher M.; Kelly, Siu Pui Ying; Ibrahim, Hasan M. S.; Hulpia, Fabian; Al-Salabi, Mohammed, I; Eze, Anthonius A.; Sprenger, Teresa; Teka, Ibrahim A.; Gudin, Simon; Weyand, Simone; Field, Mark; Dardonville, Christophe; Tidwell, Richard R.; Carrington, Mark; O'Neill, Paul; Boykin, David W.; Zachariae, Ulrich; De Koning, Harry P. 分享 收藏