George W. J. Fleet - Publications, H-index & Citations

George W. J. Fleet

university of chinese academy of sciences, cas

64H指数

762论文数

1.7W被引数

收录论文 66

发表时间

C-2 fluorinated castanospermines as potent and specific α-glucosidase inhibitors: synthesis and structure-activity relationship study C-2氟代康斯坦索斯品碱作为强效且特异性的α-葡萄糖苷酶抑制剂：合成与构效关系研究

ORGANIC & BIOMOLECULAR CHEMISTRY

IF2.7

2025-01-01

PREAI

Li, Yi-Xian; Zhang, Ming; Shimadate, Yuna; Kato, Atsushi; Wang, Jun-Zhe; Jia, Yue-Mei; Fleet, George W. J.; Yu, Chu-Yi

Design and Pharmacological Chaperone Effects of N-(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-06-14

PREAI

Kato, Atsushi; Nakagome, Izumi; Kise, Maki; Yoshimura, Kousuke; Tanaka, Nobutada; Nash, Robert J.; Fleet, George W. J.; Kobayashi, Yota; Ikeda, Hayato; Okada, Takuya; Toyooka, Naoki

Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-02-01

PREAI

Zi, Dong; Song, Ying-Ying; Lu, Tian-Tian; Kise, Maki; Kato, Atsushi; Wang, Jun-Zhe; Jia, Yue-Mei; Li, Yi-Xian; Fleet, George W. J.; Yu, Chu-Yi

C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-12-01

PREAI

Li, Yi-Xian; Wang, Jun-Zhe; Shimadate, Yuna; Kise, Maki; Kato, Atsushi; Jia, Yue-Mei; Fleet, George W. J.; Yu, Chu-Yi

Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

MOLECULES

IF4.6

2022-05-23

OAAI

Olajide, Olumayokun A.; Iwuanyanwu, Victoria U.; Banjo, Owolabi W.; Kato, Atsushi; Penkova, Yana B.; Fleet, George W. J.; Nash, Robert J.

Diastereoselective Synthesis, Glycosidase Inhibition, and Docking Study of C-7-Fluorinated Casuarine and Australine Derivatives

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2022-05-18

PREAI

Li, Yi-Xian; Wang, Jun-Zhe; Shimadate, Yuna; Kise, Maki; Kato, Atsushi; Jia, Yue-Mei; Fleet, George W. J.; Yu, Chu-Yi

Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-04-01

OAAI

Wang, Jun-Zhe; Cheng, Bin; Kato, Atsushi; Kise, Maki; Shimadate, Yuna; Jia, Yue-Mei; Li, Yi-Xian; Fleet, George W. J.; Yu, Chu-Yi

5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-01-24

PREAI

Kato, Atsushi; Nakagome, Izumi; Kanekiyo, Uta; Lu, Tian-Tian; Li, Yi-Xian; Yoshimura, Kosuke; Kishida, Mana; Shinzawa, Kenta; Yoshida, Tomoki; Tanaka, Nobutada; Jia, Yue-Mei; Nash, Robert J.; Fleet, George W. J.; Yu, Chu-Yi

Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-L-ido-DNJ derivatives 5-c-烷基-dnj和5-c-烷基-l-ido-dnj衍生物的合成和糖苷酶抑制

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-11-01

OAAI

Lu, Tian-Tian; Shimadate, Yuna; Cheng, Bin; Kanekiyo, Uta; Kato, Atsushi; Wang, Jun-Zhe; Li, Yi-Xian; Jia, Yue-Mei; Fleet, George W. J.; Yu, Chu-Yi

Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity

ACS OMEGA

IF4.3

2020-06-23

OAAI

Nash, Robert J.; Bartholomew, Barbara; Penkova, Yana B.; Rotondo, Dino; Yamasaka, Fernanda; Stafford, Graham P.; Jenkinson, Sarah F.; Fleet, George W. J.

Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity

MOLECULES

IF4.6

2020-06-19

OAAI

Kato, Atsushi; Nakagome, Izumi; Hata, Mizuki; Nash, Robert J.; Fleet, George W. J.; Natori, Yoshihiro; Yoshimura, Yuichi; Adachi, Isao; Hirono, Shuichi

Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit of Simplified Structures and Potent β-N-Acetylhexosaminidase Inhibition Pochonicine的吡咯烷单环类似物及其立体异构体的合成: 追求简化的结构和有效的 β-n-乙酰氨基己糖苷酶抑制作用

MOLECULES

IF4.6

2020-03-25

OAAI

Yan, Xin; Shimadate, Yuna; Kato, Atsushi; Li, Yi-Xian; Jia, Yue-Mei; Fleet, George W. J.; Yu, Chu-Yi

d-Idose, d-Iduronic Acid, and d-Idonic Acid from d-Glucose via Seven-Carbon Sugars d-葡萄糖通过七碳糖从d-葡萄糖中提取d-阿杜糖，d-阿杜糖醛酸和d-四烯酸

MOLECULES

IF4.6

2019-10-18

OAAI

Liu, Zilei; Jenkinson, Sarah F.; Yoshihara, Akihide; Wormald, Mark R.; Izumori, Ken; Fleet, George W. J.

Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2019-06-01

PREAI

Kato, Atsushi; Koyama, Junna; Shinzawa, Kenta; Imaeda, Shuki; Adachi, Isao; Nash, Robert J.; Fleet, George W. J.; Shintani, Megumi; Takeuchi, Chihiro; Ishikawa, Fumihiro

Isolation from Stevia rebaudiana of DMDP acetic acid, a novel iminosugar amino acid: synthesis and glycosidase inhibition profile of glycine and β-alanine pyrrolidine amino acids

AMINO ACIDS

IF2.4

2019-05-11

OAAI

Fernando Martinez, R.; Jenkinson, Sarah F.; Nakagawa, Shinpei; Kato, Atsushi; Wormald, Mark R.; Fleet, George W. J.; Hollinshead, Jackie; Nash, Robert J.

Biological activities of 3,4,5-trihydroxypiperidines and their N- and O-derivatives

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2018-04-16

PREAI

Prichard, Kate; Campkin, David; O'Brien, Nicholas; Kato, Atsushi; Fleet, George W. J.; Simone, Michela I.

Strategy for designing selective α-L-rhamnosidase inhibitors: Synthesis and biological evaluation of L-DMDP cyclic isothioureas

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2017-01-01

PREAI

Miyawaki, Shota; Hirokami, Yuki; Kinami, Kyoko; Hoshino, Masako; Minehira, Daisuke; Miyamoto, Daiki; Nash, Robert J.; Fleet, George W. J.; Adachi, Isao; Toyooka, Naoki; Kato, Atsushi

Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of D-Gulose, 6-Deoxy-D-gulose, L-Glucose, 6-Deoxy-L-glucose, and Related Sugars

ORGANIC LETTERS

IF5

2016-08-03

PREAI

Liu, Zilei; Yoshihara, Akihide; Jenkinson, Sarah F.; Wormald, Mark R.; Estevez, Ramon J.; Fleet, George W. J.; Izumori, Ken

6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2016-07-21

OAAI

Liu, Zilei; Yoshihara, Akihide; Kelly, Ciaran; Heap, John T.; Marqvorsen, Mikkel H. S.; Jenkinson, Sarah F.; Wormald, Mark R.; Otero, Jose M.; Estevez, Amalia; Kato, Atsushi; Fleet, George W. J.; Estevez, Ramon J.; Izumori, Ken

Synthetic Chemical Inducers and Genetic Decoupling Enable Orthogonal Control of the rhaBAD Promoter

ACS SYNTHETIC BIOLOGY

IF3.9

2016-06-21

OAAI

Kelly, Ciaran L.; Liu, Zilei; Yoshihara, Akihide; Jenkinson, Sarah F.; Wormald, Mark R.; Otero, Jose; Estevez, Amalia; Kato, Atsushi; Marqvorsen, Mikkel H. S.; Fleet, George W. J.; Estevez, Ramon J.; Izumori, Ken; Heap, John T.

研究方向