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Safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral allosteric TYK2 inhibitor ESK-001 using a randomized, double-blind, placebo-controlled study design Ucpinar, Sibel; Kwan, Joyce K.; Hoffman, Joshua D.; Tilley, Mera K.; Douglas, Jeffrey A.; Rubio, Roman G.; Lu, Ruixiao; Nunn, Philip A.; Langrish, Claire L. 分享 收藏
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (vol 51, pg 481, 2019) 跨多个祖先的肺功能突出通路和慢性阻塞性肺疾病关联的新遗传信号 (第51卷，481页，2019) Shrine, Nick; Guyatt, Anna L.; Erzurumluoglu, A. Mesut; Jackson, Victoria E.; Hobbs, Brian D.; Melbourne, Carl A.; Batini, Chiara; Fawcett, Katherine A.; Song, Kijoung; Sakornsakolpat, Phuwanat; Li, Xingnan; Boxall, Ruth; Reeve, Nicola F.; Obeidat, Ma'en; Zhao, Jing Hua; Wielscher, Matthias; Weiss, Stefan; Kentistou, Katherine A.; Cook, James P.; Sun, Benjamin B.; Zhou, Jian; Hui, Jennie; Karrasch, Stefan; Imboden, Medea; Harris, Sarah E.; Marten, Jonathan; Enroth, Stefan; Kerr, Shona M.; Surakka, Ida; Vitart, Veronique; Lehtimaeki, Terho; Allen, Richard J.; Bakke, Per S.; Beaty, Terri H.; Bleecker, Eugene R.; Bosse, Yohan; Brandsma, Corry-Anke; Chen, Zhengming; Crapo, James D.; Danesh, John; DeMeo, Dawn L.; Dudbridge, Frank; Ewert, Ralf; Gieger, Christian; Gulsvik, Amund; Hansell, Anna L.; Hao, Ke; Hoffman, Joshua D.; Hokanson, John E.; Homuth, Georg; Joshi, Peter K.; Joubert, Philippe; Langenberg, Claudia; Li, Xuan; Li, Liming; Lin, Kuang; Lind, Lars; Locantore, Nicholas; Luan, Jian'an; Mahajan, Anubha; Maranville, Joseph C.; Murray, Alison; Nickle, David C.; Packer, Richard; Parker, Margaret M.; Paynton, Megan L.; Porteous, David J.; Prokopenko, Dmitry; Qiao, Dandi; Rawal, Rajesh; Runz, Heiko; Sayers, Ian; Sin, Don D.; Smith, Blair H.; Artigas, Maria Soler; Sparrow, David; Tal-Singer, Ruth; Timmers, Paul R. H. J.; Van den Berge, Maarten; Whittaker, John C.; Woodruff, Prescott G.; Yerges-Armstrong, Laura M.; Troyanskaya, Olga G.; Raitakari, Olli T.; Kaehoenen, Mika; Polasek, Ozren; Gyllensten, Ulf; Rudan, Igor; Deary, Ian J.; Probst-Hensch, Nicole M.; Schulz, Holger; James, Alan L.; Wilson, James F.; Stubbe, Beate; Zeggini, Eleftheria; Jarvelin, Marjo-Riitta; Wareham, Nick; Silverman, Edwin K.; Hayward, Caroline; Morris, Andrew P.; Butterworth, Adam S.; Scott, Robert A.; Walters, Robin G.; Meyers, Deborah A.; Cho, Michael H.; Strachan, David P.; Hall, Ian P.; Tobin, Martin D.; Wain, Louise V. 分享 收藏
Genetics plays a limited role in predicting chronic obstructive pulmonary disease treatment response and exacerbation Hosking, Louise; Yeo, Astrid; Hoffman, Joshua; Chiano, Mathias; Fraser, Dana; Ghosh, Soumitra; Lipson, David A.; Martin, Neil; Condreay, Lynn D.; Cox, Charles; St Jean, Pamela 分享 收藏
Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts Graff, Rebecca E.; Cavazos, Taylor B.; Thai, Khanh K.; Kachuri, Linda; Rashkin, Sara R.; Hoffman, Joshua D.; Alexeeff, Stacey E.; Blatchins, Maruta; Meyers, Travis J.; Leong, Lancelote; Tai, Caroline G.; Emami, Nima C.; Corley, Douglas A.; Kushi, Lawrence H.; Ziv, Elad; Van den Eeden, Stephen K.; Jorgenson, Eric; Hoffmann, Thomas J.; Habel, Laurel A.; Witte, John S.; Sakoda, Lori C. 分享 收藏
GENETIC VARIANTS DO NOT PREDICT ACUTE COPD EXACERBATIONS OR TREATMENT RESPONSE TO FLUTICASONE FUROATE/UMECLIDINIUM/VILANTEROL (FF/UMEC/VI) AND ITS COMPONENTS Hosking, Louise; Yeo, Astrid; Hoffman, Joshua; Chiano, Mathias; Fraser, Dana; Ghosh, Soumitra; Lipson, David; Martin, Neil; Condreay, Lynn; Cox, Charles; Stjean, Pamela 分享 收藏
Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts 泛癌症研究在两个大型队列中检测遗传风险变异和共享遗传基础 Rashkin, Sara R.; Graff, Rebecca E.; Kachuri, Linda; Thai, Khanh K.; Alexeeff, Stacey E.; Blatchins, Maruta A.; Cavazos, Taylor B.; Corley, Douglas A.; Emami, Nima C.; Hoffman, Joshua D.; Jorgenson, Eric; Kushi, Lawrence H.; Meyers, Travis J.; Van den Eeden, Stephen K.; Ziv, Elad; Habel, Laurel A.; Hoffmann, Thomas J.; Sakoda, Lori C.; Witte, John S. 分享 收藏
Age-of-onset information helps identify 76 genetic variants associated with allergic disease 发病年龄信息有助于识别与过敏性疾病相关的76种遗传变异 Ferreira, Manuel A. R.; Vonk, Judith M.; Baurecht, Hansjoerg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D.; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Grosche, Sarah; Rueschendorf, Franz; Granell, Raquel; Brumpton, Ben M.; Fritsche, Lars G.; Bhatta, Laxmi; Gabrielsen, Maiken E.; Nielsen, Jonas B.; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir L.; Loset, Mari; Abecasis, Goncalo R.; Willer, Cristen J.; Emami, Nima C.; Cavazos, Taylor B.; Witte, John S.; Szwajda, Agnieszka; Hinds, David A.; Huebner, Norbert; Weidinger, Stephan; Magnusson, Patrik K. E.; Jorgenson, Eric; Karlsson, Robert; Paternoster, Lavinia; Boomsma, Dorret, I; Almqvist, Catarina; Lee, Young-Ae; Koppelman, Gerard H. 分享 收藏
Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms (vol 10, 3107, 2019) Emami, Nima C.; Kachuri, Linda; Meyers, Travis J.; Das, Rajdeep; Hoffman, Joshua D.; Hoffmann, Thomas J.; Hu, Donglei; Shan, Jun; Feng, Felix Y.; Ziv, Elad; Van den Eeden, Stephen K.; Witte, John S. 分享 收藏
Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms Emami, Nima C.; Kachuri, Linda; Meyers, Travis J.; Das, Rajdeep; Hoffman, Joshua D.; Hoffmann, Thomas J.; Hu, Donglei; Shan, Jun; Feng, Felix Y.; Ziv, Elad; Van den Eeden, Stephen K.; Witte, John S. 分享 收藏
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (vol 51, pg 481, 2019) 跨多个祖先的肺功能突出通路和慢性阻塞性肺疾病关联的新遗传信号 (第51卷，481页，2019) Shrine, Nick; Guyatt, Anna L.; Erzurumluoglu, A. Mesut; Jackson, Victoria E.; Hobbs, Brian D.; Melbourne, Carl A.; Batini, Chiara; Fawcett, Katherine A.; Song, Kijoung; Sakornsakolpat, Phuwanat; Li, Xingnan; Boxall, Ruth; Reeve, Nicola F.; Obeidat, Ma'en; Zhao, Jing Hua; Wielscher, Matthias; Weiss, Stefan; Kentistou, Katherine A.; Cook, James P.; Sun, Benjamin B.; Zhou, Jian; Hui, Jennie; Karrasch, Stefan; Imboden, Medea; Harris, Sarah E.; Marten, Jonathan; Enroth, Stefan; Kerr, Shona M.; Surakka, Ida; Vitart, Veronique; Lehtimaki, Terho; Allen, Richard J.; Bakke, Per S.; Beaty, Terri H.; Bleecker, Eugene R.; Bosse, Yohan; Brandsma, Corry-Anke; Chen, Zhengming; Crapo, James D.; Danesh, John; Demeo, Dawn L.; Dudbridge, Frank; Ewert, Ralf; Gieger, Christian; Gulsvik, Amund; Hansell, Anna L.; Hao, Ke; Hoffman, Joshua D.; Hokanson, John E.; Homuth, Georg; Joshi, Peter K.; Joubert, Philippe; Langenberg, Claudia; Li, Xuan; Li, Liming; Lin, Kuang; Lind, Lars; Locantore, Nicholas; Luan, Jian'an; Mahajan, Anubha; Maranville, Joseph C.; Murray, Alison; Nickle, David C.; Packer, Richard; Parker, Margaret M.; Paynton, Megan L.; Porteous, David J.; Prokopenko, Dmitry; Qiao, Dandi; Rawal, Rajesh; Runz, Heiko; Sayers, Ian; Sin, Don D.; Smith, Blair H.; Artigas, Maria Soler; Sparrow, David; Tal-Singer, Ruth; Timmers, Paul R. H. J.; Van den Berge, Maarten; Whittaker, John C.; Woodruff, Prescott G.; Yerges-Armstrong, Laura M.; Troyanskaya, Olga G.; Raitakari, Olli T.; Kahonen, Mika; Polasek, Ozren; Gyllensten, Ulf; Rudan, Igor; Deary, Ian J.; Probst-Hensch, Nicole M.; Schulz, Holger; James, Alan L.; Wilson, James F.; Stubbe, Beate; Zeggini, Eleftheria; Jarvelin, Marjo-Riitta; Wareham, Nick; Silverman, Edwin K.; Hayward, Caroline; Morris, Andrew P.; Butterworth, Adam S.; Scott, Robert A.; Walters, Robin G.; Meyers, Deborah A.; Cho, Michael H.; Strachan, David P.; Hall, Ian P.; Tobin, Martin D.; Wain, Louise V. 分享 收藏
GENOME-WIDE ANALYSES USING UK BIOBANK DATA POVIDE NEW THERAPEUTIC TARGETS FOR OSTEOARTHRITIS Hatzikotoulas, K.; Tachmazidou, I.; Southam, L.; Esparza-Gordillo, J.; Haberland, V.; Zheng, J.; Johnson, T.; Koprulu, M.; Zengini, E.; Steinberg, J.; Wilkinson, J.; Bhatnagar, S.; Hoffman, J.; Buchan, N.; Suveges, D.; Yerges-Armstrong, L.; Davey-Smith, G.; Gaunt, T.; Scott, R.; McCarthy, L.; Zeggini, E. 分享 收藏
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries 肺功能的新遗传信号突出通路和跨多个祖先的慢性阻塞性肺疾病关联 Shrine, Nick; Guyatt, Anna L.; Erzurumluoglu, A. Mesut; Jackson, Victoria E.; Hobbs, Brian D.; Melbourne, Carl A.; Batini, Chiara; Fawcett, Katherine A.; Song, Kijoung; Sakornsakolpat, Phuwanat; Li, Xingnan; Boxall, Ruth; Reeve, Nicola F.; Obeidat, Ma'en; Zhao, Jing Hua; Wielscher, Matthias; Weiss, Stefan; Kentistou, Katherine A.; Cook, James P.; Sun, Benjamin B.; Zhou, Jian; Hui, Jennie; Karrasch, Stefan; Imboden, Medea; Harris, Sarah E.; Marten, Jonathan; Enroth, Stefan; Kerr, Shona M.; Surakka, Ida; Vitart, Veronique; Lehtimaki, Terho; Allen, Richard J.; Bakke, Per S.; Beaty, Terri H.; Bleecker, Eugene R.; Bosse, Yohan; Brandsma, Corry-Anke; Chen, Zhengming; Crapo, James D.; Danesh, John; DeMeo, Dawn L.; Dudbridge, Frank; Ewert, Ralf; Gieger, Christian; Gulsvik, Amund; Hansell, Anna L.; Hao, Ke; Hoffman, Joshua D.; Hokanson, John E.; Homuth, Georg; Joshi, Peter K.; Joubert, Philippe; Langenberg, Claudia; Li, Xuan; Li, Liming; Lin, Kuang; Lind, Lars; Locantore, Nicholas; Luan, Jian'an; Mahajan, Anubha; Maranville, Joseph C.; Murray, Alison; Nickle, David C.; Packer, Richard; Parker, Margaret M.; Paynton, Megan L.; Porteous, David J.; Prokopenko, Dmitry; Qiao, Dandi; Rawal, Rajesh; Runz, Heiko; Sayers, Ian; Sin, Don D.; Smith, Blair H.; Artigas, Maria Soler; Sparrow, David; Tal-Singer, Ruth; Timmers, Paul R. H. J.; Van den Berge, Maarten; Whittaker, John C.; Woodruff, Prescott G.; Verges-Armstrong, Laura M.; Troyanskaya, Olga G.; Raitakari, Olli T.; Kahonenn, Mika; Polasek, Ozren; Gyllensten, Ulf; Rudan, Igor; Deary, Ian J.; Probst-Hensch, Nicole M.; Schulz, Holger; James, Alan L.; Wilson, James F.; Stubbe, Beate; Zeggini, Eleftheria; Jarvelin, Marjo-Riitta; Wareham, Nick; Silverman, Edwin K.; Hayward, Caroline; Morris, Andrew P.; Butterworth, Adam S.; Scott, Robert A.; Walters, Robin G.; Meyers, Deborah A.; Cho, Michael H.; Strachan, David P.; Hall, Ian P.; Tobin, Martin D.; Wain, Louise, V 分享 收藏
Eleven loci with new reproducible genetic associations with allergic disease risk Ferreira, Manuel A. R.; Vonk, Judith M.; Baurecht, Hansjorg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D.; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Ruschendorf, Franz; Hinds, David A.; Hubner, Norbert; Weidinger, Stephan; Magnusson, Patrik K. E.; Jorgenson, Eric; Lee, Young-Ae; Boomsma, Dorret I.; Karlsson, Robert; Almqvist, Catarina; Koppelman, Gerard H.; Paternoster, Lavinia 分享 收藏
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data Tachmazidou, Ioanna; Hatzikotoulas, Konstantinos; Southam, Lorraine; Esparza-Gordillo, Jorge; Haberland, Valeriia; Zheng, Jie; Johnson, Toby; Koprulu, Mine; Zengini, Eleni; Steinberg, Julia; Wilkinson, Jeremy M.; Bhatnagar, Sahir; Hoffman, Joshua D.; Buchan, Natalie; Suveges, Daniel; Yerges-Armstrong, Laura; Smith, George Davey; Gaunt, Tom R.; Scott, Robert A.; McCarthy, Linda C.; Zeggini, Eleftheria 分享 收藏
Identification of novel common breast cancer risk variants at the 6q25 locusamong Latinas Hoffman, Joshua; Fejerman, Laura; Hu, Donglei; Huntsman, Scott; Li, Min; John, Esther M.; Torres-Mejia, Gabriela; Kushi, Larry; Ding, Yuan Chun; Weitzel, Jeffrey; Neuhausen, Susan L.; Lott, Paul; Echeverry, Magdalena; Carvajal-Carmona, Luis; Burchard, Esteban; Eng, Celeste; Long, Jirong; Zheng, Wei; Olopade, Olufunmilayo; Huo, Dezheng; Haiman, Christopher; Ziv, Elad 分享 收藏
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A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma Asai, Yuka; Eslami, Aida; van Ginkel, C. Dorien; Akhabir, Loubna; Wan, Ming; Yin, David; Ellis, George; Ben-Shoshan, Moshe; Marenholz, Ingo; Martino, David; Ferreira, Manuel A.; Allen, Katrina; Mazer, Bruce; de Groot, Hans; de Jong, Nicolette W.; van Wijk, Roy Gerth; Dubois, Anthony E. J.; Grosche, Sarah; Ashley, Sarah; Rueschendorf, Franz; Kalb, Birgit; Beyer, Kirsten; Noethen, Markus M.; Lee, Young-Ae; Chin, Rick; Cheuk, Stephen; Hoffman, Joshua; Jorgensen, Eric; Witte, John S.; Melles, Ronald B.; Hong, Xiumei; Wang, Xiaobin; Hui, Jennie; Musk, Arthur W. (Bill); Hunter, Michael; James, Alan L.; Koppelman, Gerard H.; Sandford, Andrew J.; Clarke, Ann E.; Daley, Denise 分享 收藏
Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy Asai, Yuka; Eslami, Aida; van Ginkel, C. Dorien; Akhabir, Loubna; Wan, Ming; Ellis, George; Ben-Shoshan, Moshe; Martino, David; Ferreira, Manuel A.; Allen, Katrina; Mazer, Bruce; de Groot, Hans; de Jong, Nicolette W.; van Wijk, Roy N. Gerth; Dubois, Anthony E. J.; Chin, Rick; Cheuk, Stephen; Hoffman, Joshua; Jorgensen, Eric; Witte, John S.; Melles, Ronald B.; Hong, Xiumei; Wang, Xiaobin; Hui, Jennie; Musk, Arthur W. (Bill); Hunter, Michael; James, Alan L.; Koppelman, Gerard H.; Sandford, Andrew J.; Clarke, Ann E.; Daley, Denise 分享 收藏
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