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J

Jean C. Tien

university of michigan
H指数:22
被引数:1,986

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Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer

通过p300/CBP降解靶向前列腺癌中乙酰化的H2B组蛋白增强子复合物

Nature Genetics
IF29
2025-10-030
OAAI
Jie Luo; Zhixiang Chen; Yuanyuan Qiao; Jean Ching-Yi Tien; Eleanor Young; Rahul Mannan; Somnath Mahapatra; Rupam Bhattacharyya; Lanbo Xiao; Tongchen He; Sanjana Eyunni; Yuping Zhang; Yang Zheng; Fengyun Su; Xuhong Cao; Rui Wang; Yunhui Cheng; Rithvik Seri; James George; Miriam Shahine; Stephanie J. Miner; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Ulka Vaishampayan; Mi Wang; Shaomeng Wang; Abhijit Parolia; Arul M. Chinnaiyan
CDK12/13 inactivation triggers STING-mediated antitumor immunity in preclinical models

CDK12/13失活触发STING介导的抗肿瘤免疫在临床前模型中

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-09-160
OA
Bao, Yi; Chang, Yu; Tien, Jean Ching-Yi; Cruz, Gabriel; Yang, Fan; Mannan, Rahul; Mahapatra, Somnath; Paturu, Radha; Cao, Xuhong; Su, Fengyun; Wang, Rui; Zhang, Yuping; Gondal, Mahnoor; Choi, Jae eun; Gurkan, Jonathan K.; Miner, Stephanie J.; Robinson, Dan R.; Wu, Yi-Mi; Zhou, Licheng; Wang, Zhen; Kryczek, Ilona; Wang, Xiaoju; Cieslik, Marcin; Qiao, Yuanyuan; Tsodikov, Alexander; Zou, Weiping; Ding, Ke; Chinnaiyan, Arul M.
Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity

不同的FOXA1突变驱动前列腺肿瘤发生和治疗抵抗性细胞可塑性

Science
IF45.8
2025-01-010
OA
Sanjana Eyunni; Rahul Mannan; Yuping Zhang; Eleanor Young; Qiuyang Zhang; Jie Luo; Matthew Pang; Somnath Mahapatra; Jean Ching-Yi Tien; James M. George; Mustapha Jaber; Hamzah Hakkani; Sandra E. Carson; Abigail J. Todd; Noshad Hosseini; Mahnoor Naseer Gondal; Ryan James Rebernick; Xuhong Cao; Fengyun Su; Rui Wang; Rohit Mehra; Jing Li; Marcin P. Cieslik; Arul M. Chinnaiyan; Abhijit Parolia
CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13
CELL REPORTS MEDICINE
IF10.6
2024-10-010
OAAI
Tien, Jean Ching-Yi; Luo, Jie; Chang, Yu; Zhang, Yuping; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Mahapatra, Somnath; Shah, Palak; Wang, Xiao-Ming; Todd, Abigail J.; Eyunni, Sanjana; Cheng, Caleb; Rebernick, Ryan J.; Xiao, Lanbo; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen J.; Cao, Xuhong; Miner, Stephanie J.; Zhou, Licheng; Wu, Yi-Mi; Labanca, Estefania; Wang, Yuzhuo; Parolia, Abhijit; Cieslik, Marcin; Robinson, Dan R.; Wang, Zhen; Feng, Felix Y.; Chou, Jonathan; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.
CDK12 loss promotes prostate cancer development while exposing vulnerabilities to paralog-based synthetic lethality
MOLECULAR CANCER THERAPEUTICS
IF5.5
2024-06-100
PRE
Tien, Jean C.; Chang, Yu; Zhang, Yuping; Chou, Jonathan; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Shah, Palak; Wang, Xiao-Ming; Todd, Abbey; Eyunni, Sanjana; Cheng, Caleb; Cao, Xuhong; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen; Labanca, Estefania; Wang, Yuzhuo; Cieslik, Marcin; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.
Autophagy inhibition by targeting PIKfyve potentiates response to immune checkpoint blockade in prostate cancer
NATURE CANCER
IF28.5
2021-08-0262
OAAI
Qiao, Yuanyuan; Choi, Jae Eun; Tien, Jean C.; Simko, Stephanie A.; Rajendiran, Thekkelnaycke; Vo, Josh N.; Delekta, Andrew D.; Wang, Lisha; Xiao, Lanbo; Hodge, Nathan B.; Desai, Parth; Mendoza, Sergio; Juckette, Kristin; Xu, Alice; Soni, Tanu; Su, Fengyun; Wang, Rui; Cao, Xuhong; Yu, Jiali; Kryczek, Ilona; Wang, Xiao-Ming; Wang, Xiaoju; Siddiqui, Javed; Wang, Zhen; Bernard, Amelie; Fernandez-Salas, Ester; Navone, Nora M.; Ellison, Stephanie J.; Ding, Ke; Eskelinen, Eeva-Liisa; Heath, Elisabeth I.; Klionsky, Daniel J.; Zou, Weiping; Chinnaiyan, Arul M.
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer

AGO2促进KRAS驱动的非小细胞肺癌小鼠模型的肿瘤进展

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2021-05-1020
OAAI
Tien, Jean Ching-Yi; Chugh, Seema; Goodrum, Andrew E.; Cheng, Yunhui; Mannan, Rahul; Zhang, Yuping; Wang, Lisha; Dommeti, Vijaya L.; Wang, Xiaoming; Xu, Alice; Hon, Jennifer; Kenum, Carson; Su, Fengyun; Wang, Rui; Cao, Xuhong; Shankar, Sunita; Chinnaiyan, Arul M.
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

SARS-CoV-2进入因子ACE2和TMPRSS2的靶向转录调控

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2020-12-28132
OAAI
Qiao, Yuanyuan; Wang, Xiao-Ming; Mannan, Rahul; Pitchiaya, Sethuramasundaram; Zhang, Yuping; Wotring, Jesse W.; Xiao, Lanbo; Robinson, Dan R.; Wu, Yi-Mi; Tien, Jean Ching-Yi; Cao, Xuhong; Simko, Stephanie A.; Apel, Ingrid J.; Bawa, Pushpinder; Kregel, Steven; Narayanan, Sathiya P.; Raskind, Gregory; Ellison, Stephanie J.; Parolia, Abhijit; Zelenka-Wang, Sylvia; McMurry, Lisa; Su, Fengyun; Wang, Rui; Cheng, Yunhui; Delekta, Andrew D.; Mei, Zejie; Pretto, Carla D.; Wang, Shaomeng; Mehra, Rohit; Sexton, Jonathan Z.; Chinnaiyan, Arul M.
AGO2 interaction limits wild type RAS activation yet essential for disease progression in oncogenic KRAS driven cancers
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Shankar, Sunita; Tien, Jean Ching-Yi; Siebenaler, Ronald F.; Chugh, Seema; Dommeti, Vijaya L.; Zelenka-Wang, Sylvia; Waninger, Jessica; Juckette, Kristin M.; Wang, Xiao-Ming; Eyunni, Sanjana; Goodrum, Andrew; Zhang, Yuping; Apel, Ingrid J.; Siddiqui, Javed; Cao, Xuhong; Shi, Jiaqi; Pitchiaya, Sethuramsundaram; Kumar-Sinha, Chandan; Crawford, Howard C.; Chinnaiyan, Arul M.

研究方向

暂未获取到该数据
A
Arul M. Chinnaiyan
H 指数:144论文数:1,701被引数:9.7万
X
Xuhong Cao
H 指数:82论文数:528被引数:4.7万
I
Ingrid J. Apel
H 指数:22论文数:71被引数:3,049
S
Sunita Shankar
H 指数:18论文数:118被引数:5,353
R
Rahul Mannan
H 指数:25论文数:262被引数:3,367
K
Kristin Juckette
H 指数:7论文数:86被引数:541
V
Vijaya L. Dommeti
H 指数:6论文数:70被引数:1,381
Y
Yuanyuan Qiao
H 指数:32论文数:242被引数:4,070
L
Lisha Wang
H 指数:38论文数:342被引数:5,046
M
Marcin Cieślik
H 指数:54论文数:350被引数:2.2万