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R

Rahul Mannan

university of michigan
H指数:25
被引数:3,405

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Discovery and preclinical evaluation of ZLC853 as a potential clinical candidate covalently targeting CDK12/13 kinases

ZLC853的发现及其作为潜在临床候选药物对CDK12/13激酶的共价靶向作用的临床前评估

Acta Pharmaceutica Sinica B
IF14.6
2026-07-290
OA
Kaijie Zhou; Licheng Zhou; Jean C. Tien; Weixue Huang; Wenyan Liu; Xinyu Sun; Bohai Fan; Xin Huang; Jun Wang; Yu Chang; Jianzhang Yang; Yue Yin; Chen Su; Qingrun Li; Rahul Mannan; Somnath Mahapatra; Yunhui Cheng; Abigail J. Todd; Christina E. Wheeler; Shuqin Li
Distinct clinicopathological and survival profiles of CLDN18.2 and PD-L1 expression in advanced gastric cancer and gastroesophageal junction adenocarcinoma

进展期胃癌和胃食管结合部腺癌中CLDN18.2和PD-L1表达的不同临床病理和生存特征

ESMO Gastrointestinal Oncology
IF0
2025-11-010
OAAI
Castillo, D. R.; Guo, M.; Shah, P.; Hazeltin, M.; Tai, D.; Al-Manaseer, F.; Mlamba, S.; Perez, D.; Yeremian, S.; Guzman, S.; Mannan, R.; Crook, C.; Lau, C.; Tawar, N.; Brar, G.; Raoof, M.; Woo, Y.; Wu, S. P.; Li, D.
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer

通过p300/CBP降解靶向前列腺癌中乙酰化的H2B组蛋白增强子复合物

Nature Genetics
IF29
2025-10-030
OAAI
Jie Luo; Zhixiang Chen; Yuanyuan Qiao; Jean Ching-Yi Tien; Eleanor Young; Rahul Mannan; Somnath Mahapatra; Rupam Bhattacharyya; Lanbo Xiao; Tongchen He; Sanjana Eyunni; Yuping Zhang; Yang Zheng; Fengyun Su; Xuhong Cao; Rui Wang; Yunhui Cheng; Rithvik Seri; James George; Miriam Shahine; Stephanie J. Miner; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Ulka Vaishampayan; Mi Wang; Shaomeng Wang; Abhijit Parolia; Arul M. Chinnaiyan
CDK12/13 inactivation triggers STING-mediated antitumor immunity in preclinical models

CDK12/13失活触发STING介导的抗肿瘤免疫在临床前模型中

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-09-160
OA
Bao, Yi; Chang, Yu; Tien, Jean Ching-Yi; Cruz, Gabriel; Yang, Fan; Mannan, Rahul; Mahapatra, Somnath; Paturu, Radha; Cao, Xuhong; Su, Fengyun; Wang, Rui; Zhang, Yuping; Gondal, Mahnoor; Choi, Jae eun; Gurkan, Jonathan K.; Miner, Stephanie J.; Robinson, Dan R.; Wu, Yi-Mi; Zhou, Licheng; Wang, Zhen; Kryczek, Ilona; Wang, Xiaoju; Cieslik, Marcin; Qiao, Yuanyuan; Tsodikov, Alexander; Zou, Weiping; Ding, Ke; Chinnaiyan, Arul M.
TRIM63 Overexpression in FISH-Negative MiTF Family Altered Renal Cell Carcinoma (MiTF RCC)

TRIM63在FISH阴性MiTF家族改变的肾细胞癌（MiTF RCC）中的过表达

Modern Pathology
IF5.5
2025-08-250
PREAI
Rahul Mannan; Ying-Bei Chen; Xiaoming Wang; Yuping Zhang; Noshad Hosseini; Ankur R. Sangoi; Andres Acosta; Sean R. Williamson; Somnath Mahapatra; Anya K. Chinnaiyan; Jing Hu; Ulka Vaishampayan; Lina Shao; Bryan L. Betz; Annette S. Kim; Xuhong Cao; Fengyun Su; Rui Wang; Pedram Argani; Noah Brown; Satish K. Tickoo; Arul M. Chinnaiyan; Victor E. Reuter; Saravana M. Dhanasekaran; Rohit Mehra
Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures

不同种族和暴露因素下肺腺癌的整合分析

Cancer Cell
IF44.5
2025-07-310
OAAI
Shankha Satpathy; Natalie M. Clark; Yi-Ju Chen; Noshad Hosseini; Ya-Hsuan Chang; Yi Hsiao; Jonathan T. Lei; Francesca Petralia; Jin-Shing Chen; Yifat Geffen; David I. Heiman; Indranil Paul; Hanbyul Cho; Michelle Hollenberg; Giacomo B. Marino; Kuen-Tyng Lin; Rahul Mannan; C. Jackson White; Joe Allen; Shayan C. Avanessian; M. Harry Kane; Ashley Wolfe; Miloni Kinarivala; Wenke Liu; Shankara Anand; Mong-Wei Lin; Moe Haines; Erik J. Bergstrom; Grant Hussey; Ginny Xiaohe Li; Deepak C. Mani; Hao Fang; Eric J. Jaehnig; Hasmik Keshishian; Brecca Miller; Kang-Yi Su; Yi-Jing Hsiao; Hsao-Hsun Hsu; Min-Shu Hsieh; Kuo-Hsuan Hsu; Alexi Monovoukas; Simone Gohsman; John R. Thorup; Yamei Deng; Yo Akiyama; Eden Deng; Eric Sheng-Wen Chen; Azra Krek; Rodrigo Espinoza; Weiping Ma; Daniel Charytonowicz; Robert Sebra; Jyun-Hong Lin; Yan-Si Chen; Yin-Chen Hsu; Ze-Shiang Lin; Kun-Chieh Chen; Chang-Wei Yeh; Yu-Tai Wang; Alexander J. Lazar; Mehdi Mesri; Eunkyung An; Xu Zhang; Karl R. Clauser; David Fenyö; Arul M. Chinnaiyan; Bing Zhang; Li Ding; Kelly Ruggles; Chelsea Newton; Hui Zhang; Pei Wang; Galen Hostetter; Gilbert S. Omenn; Chandan Kumar-Sinha; Mathangi Thiagarajan; Ramaswamy Govindan; Paul Paik; Abhijit Parolia; Qing K. Li; Avi Ma’ayan; Gad A. Getz; Saravana M. Dhanasekaran; Ana I. Robles; Gee-Chen Chang; Pan-Chyr Yang; Sung-Liang Yu; Hsuan-Yu Chen; Alexey I. Nesvizhskii; Steven A. Carr; D.R. Mani; Marcin P. Cieslik; Yu-Ju Chen; Michael A. Gillette
LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer

LSD1+8a是神经内分泌前列腺癌的RNA生物标志物

NEOPLASIA
IF7.7
2025-05-010
PRE
Kumaraswamy, Anbarasu; Mannan, Rahul; Swaim, Olivia A.; Rodansky, Eva; Wang, Xiao-Ming; Mehra, Rohit; Li, Hui; Morrissey, Colm; Haffner, Michael C.; Nelson, Peter S.; Chinnaiyan, Arul M.; Yates, Joel A.; Alumkal, Joshi J.
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer

靶向PIKfyve驱动的脂质代谢在胰腺癌中的应用

NATURE
IF48.5
2025-04-230
OA
Cheng, Caleb; Hu, Jing; Mannan, Rahul; He, Tongchen; Magnuson, Brian; Wisniewski, Jasmine P.; Peters, Sydney; Karim, Saadia A.; MacLean, David J.; Karaburk, Huseyin; Zhang, Li; Rossiter, Nicholas J.; Zheng, Yang; Xiao, Lanbo; Li, Chungen; Awad, Dominik; Mahapatra, Somnath; Bao, Yi; Zhang, Yuping; Cao, Xuhong; Wang, Zhen; Mehra, Rohit; Morlacchi, Pietro; Sahai, Vaibhav; di Magliano, Marina Pasca; Shah, Yatrik M.; Weisman, Lois S.; Morton, Jennifer P.; Ding, Ke; Qiao, Yuanyuan; Lyssiotis, Costas A.
Discovery of YJZ5118: A Potent and Highly Selective Irreversible CDK12/13 Inhibitor with Synergistic Effects in Combination with Akt Inhibition

YJZ5118的发现：一种具有协同效应的强效且高度选择性的不可逆CDK12/13抑制剂，可与Akt抑制联合用药。

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-03-130
PRE
Yang, Jianzhang; Chang, Yu; Zhou, Kaijie; Huang, Weixue; Tien, Jean Ching-Yi; Zhang, Pujuan; Liu, Wenyan; Zhou, Licheng; Zhou, Yang; Ren, Xiaomei; Mannan, Rahul; Mahapatra, Somnath; Zhang, Yuping; Hamadeh, Rudana; Ervine, Grafton; Wang, Zhen; Wang, George Xiaoju; Chinnaiyan, Arul M.; Ding, Ke
Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity

不同的FOXA1突变驱动前列腺肿瘤发生和治疗抵抗性细胞可塑性

Science
IF45.8
2025-01-010
OA
Sanjana Eyunni; Rahul Mannan; Yuping Zhang; Eleanor Young; Qiuyang Zhang; Jie Luo; Matthew Pang; Somnath Mahapatra; Jean Ching-Yi Tien; James M. George; Mustapha Jaber; Hamzah Hakkani; Sandra E. Carson; Abigail J. Todd; Noshad Hosseini; Mahnoor Naseer Gondal; Ryan James Rebernick; Xuhong Cao; Fengyun Su; Rui Wang; Rohit Mehra; Jing Li; Marcin P. Cieslik; Arul M. Chinnaiyan; Abhijit Parolia
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

开发口服生物可利用的CDK12/13降解剂并通过AKT途径抑制诱导合成致死率

CELL REPORTS
IF6.9
2024-10-011
OAAI
Chang, Yu; Wang, Xiaoju; Yang, Jianzhang; Tien, Jean Ching-Yi; Mannan, Rahul; Cruz, Gabriel; Zhang, Yuping; Vo, Josh N.; Magnuson, Brian; Mahapatra, Somnath; Cho, Hanbyul; Dhanasekaran, Saravana Mohan; Wang, Cynthia; Wang, Zhen; Zhou, Licheng; Zhou, Kaijie; Zhou, Yang; Zhang, Pujuan; Huang, Weixue; Xiao, Lanbo; Liu, Weihuang Raymond; Hamadeh, Rudana; Su, Fengyun; Wang, Rui; Miner, Stephanie J.; Cao, Xuhong; Cheng, Yunhui; Mehra, Rohit; Ding, Ke; Chinnaiyan, Arul M.
CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13
CELL REPORTS MEDICINE
IF10.6
2024-10-010
OAAI
Tien, Jean Ching-Yi; Luo, Jie; Chang, Yu; Zhang, Yuping; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Mahapatra, Somnath; Shah, Palak; Wang, Xiao-Ming; Todd, Abigail J.; Eyunni, Sanjana; Cheng, Caleb; Rebernick, Ryan J.; Xiao, Lanbo; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen J.; Cao, Xuhong; Miner, Stephanie J.; Zhou, Licheng; Wu, Yi-Mi; Labanca, Estefania; Wang, Yuzhuo; Parolia, Abhijit; Cieslik, Marcin; Robinson, Dan R.; Wang, Zhen; Feng, Felix Y.; Chou, Jonathan; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.
NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis
NATURE GENETICS
IF31.8
2024-09-092
OAAI
Parolia, Abhijit; Eyunni, Sanjana; Verma, Brijesh Kumar; Young, Eleanor; Liu, Yihan; Liu, Lianchao; George, James; Aras, Shweta; Das, Chandan Kanta; Mannan, Rahul; Rasool, Reyaz Ur; Mitchell-Velasquez, Erick; Mahapatra, Somnath; Luo, Jie; Carson, Sandra E.; Xiao, Lanbo; Gajjala, Prathibha R.; Venkatesh, Sharan; Jaber, Mustapha; Wang, Xiaoju; He, Tongchen; Qiao, Yuanyuan; Pang, Matthew; Zhang, Yuping; Tien, Jean Ching-Yi; Louw, Micheala; Alhusayan, Mohammed; Cao, Xuhong; Su, Fengyun; Tavana, Omid; Hou, Caiyun; Wang, Zhen; Ding, Ke; Chinnaiyan, Arul M.; Asangani, Irfan A.
CDK12 loss promotes prostate cancer development while exposing vulnerabilities to paralog-based synthetic lethality
MOLECULAR CANCER THERAPEUTICS
IF5.5
2024-06-100
PRE
Tien, Jean C.; Chang, Yu; Zhang, Yuping; Chou, Jonathan; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Shah, Palak; Wang, Xiao-Ming; Todd, Abbey; Eyunni, Sanjana; Cheng, Caleb; Cao, Xuhong; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen; Labanca, Estefania; Wang, Yuzhuo; Cieslik, Marcin; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.

研究方向

暂未获取到该数据
A
Arul M. Chinnaiyan
H 指数:144论文数:1,701被引数:9.7万
X
Xuhong Cao
H 指数:82论文数:528被引数:4.7万
R
Rohit Mehra
H 指数:83论文数:650被引数:3.6万
S
Saravana M. Dhanasekaran
H 指数:68论文数:248被引数:3.4万
Y
Yuanyuan Qiao
H 指数:32论文数:242被引数:4,107
S
Somnath Mahapatra
H 指数:18论文数:122被引数:1,356
M
Marcin Cieślik
H 指数:54论文数:350被引数:2.2万
苏
苏凤云
H 指数:30论文数:255被引数:8,115
X
Xiaoming Wang
H 指数:20论文数:65被引数:1,575
J
Jean C. Tien
H 指数:22论文数:132被引数:2,004