Martin Ruthardt - Publications, H-index & Citations

Martin Ruthardt

cardiff university

35H指数

143论文数

4.8K被引数

收录论文 38

发表时间

Allosteric kinase inhibition in hematological malignancies: from asciminib to emerging regulatory sites 血癌中的别构激酶抑制：从阿西米尼布到新兴调控位点

Biochemical Pharmacology

IF5.6

2026-09-06

PREAI

Ailie Marx; Maor Cohen; Martin Ruthardt; Jamal Mahajna

Mutational Signatures and Machine Learning for Risk Stratification of Acute Myeloid Leukaemia Based on Targeted Sequencing Data 基于靶向测序数据的急性髓系白血病风险分层中的突变特征与机器学习

Cancers

IF4.4

2026-06-15

OAAI

Heba Elhaddad; Claudia Chiriches; Shuvro Prokash Nandi; Patrick van Eijk; Amanda Gilkes; Katie Watts; Amy Houseman; Charlotte S. Wilhelm-Benartzi; Oliver Gerhard Ottmann; Simon H. Reed; Martin Ruthardt

Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

120

OAAI

Ruthardt, M; Testa, U; Nervi, C; Ferrucci, PF; Grignani, F; Puccetti, E; Grignani, F; Peschle, C; Pelicci, PG

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

294

OAAI

Müller-Tidow, C; Steffen, B; Cauvet, T; Tickenbrock, L; Ji, P; Diederichs, S; Sargin, B; Köhler, G; Stelljes, M; Puccetti, E; Ruthardt, M; deVos, S; Hiebert, SW; Koeffler, HP; Berdel, WE; Serve, H

Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation

PLOS GENETICS

IF3.7

2022-10-26

OAAI

Chiriches, Claudia; Nicolaisen, Nathalie; Wieske, Maria; Elhaddad, Heba; Mehmetbeyoglu, Ecmel; Alvares, Caroline; Becher, Doerte; Hole, Paul; Ottmann, Oliver Gerhard; Ruthardt, Martin

Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia

ANNALS OF HEMATOLOGY

IF2.4

2022-08-08

OAAI

Chiriches, Claudia; Khan, Dilawar; Wieske, Maria; Guillen, Nathalie; Rokicki, Michal; Guy, Carol; Wilson, Marieangela; Heesom, Kate J.; Ottmann, Oliver Gerhard; Ruthardt, Martin

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K

ANNALS OF HEMATOLOGY

IF2.4

2021-06-10

OAAI

Mian, Afsar Ali; Haberbosch, Isabella; Khamaisie, Hazem; Agbarya, Abed; Pietsch, Larissa; Eshel, Elizabeh; Najib, Dally; Chiriches, Claudia; Ottmann, Oliver Gerhard; Hantschel, Oliver; Biondi, Ricardo M.; Ruthardt, Martin; Mahajna, Jamal

Mesenchymal soluble factors confer imatinib drug resistance in chronic myelogenous leukemia cells

ARCHIVES OF MEDICAL SCIENCE

IF3.3

2021-01-05

OAAI

Regev, Ofer; Kidan, Noa; Nicola, Meshel; Khamisie, Hazem; Ruthardt, Martin; Mahajna, Jamal

The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis

LEUKEMIA

IF13.4

2019-04-08

OAAI

Mian, Afsar A.; Baumann, Ines; Liebermann, Marcus; Grebien, Florian; Superti-Furga, Giulio; Ruthardt, Martin; Ottmann, Oliver G.; Hantschel, Oliver

Ectopic Expression of Snail and Twist in Ph plus Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential

JOURNAL OF CANCER

IF3.2

2017-01-01

OAAI

Kidan, Noa; Khamaisie, Hazem; Ruimi, Nili; Roitman, Shay; Eshel, Elizabeth; Dally, Najib; Ruthardt, Martin; Mahajna, Jamal

Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

BMC CANCER

IF3.4

2016-02-23

OAAI

Ratzon, Einav; Najajreh, Yousef; Salem, Rami; Khamaisie, Hazem; Ruthardt, Martin; Mahajna, Jamal

The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome-Positive Acute Lymphatic Leukemia

PLOS GENETICS

IF3.7

2015-04-28

OAAI

Rafiei, Anahita; Mian, Afsar Ali; Doering, Claudia; Metodieva, Anna; Oancea, Claudia; Thalheimer, Frederic B.; Hansmann, Martin Leo; Ottmann, Oliver Gerhard; Ruthardt, Martin

PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph plus ) leukemias harboring the T315I mutation

LEUKEMIA

IF13.4

2014-11-14

PREAI

Mian, A. A.; Rafiei, A.; Haberbosch, I.; Zeifman, A.; Titov, I.; Stroylov, V.; Metodieva, A.; Stroganov, O.; Novikov, F.; Brill, B.; Chilov, G.; Hoelzer, D.; Ottmann, O. G.; Ruthardt, M.

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells

CELL CYCLE

IF3.4

2014-10-28

OAAI

Romanski, Annette; Schwarz, Kerstin; Keller, Maren; Wietbrauk, Sarah; Vogel, Anja; Roos, Jessica; Oancea, Claudia; Brill, Boris; Kraemer, Oliver H.; Serve, Hubert; Ruthardt, Martin; Bug, Gesine

5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell-like Cells in Acute Myeloid Leukemia

CANCER RESEARCH

IF16.6

2014-09-14

OAAI

Roos, Jessica; Oancea, Claudia; Heinssmann, Maria; Khan, Dilawar; Held, Hannelore; Kahnt, Astrid S.; Capelo, Ricardo; la Buscato, Estel; Proschak, Ewgenij; Puccetti, Elena; Steinhilber, Dieter; Fleming, Ingrid; Maier, Thorsten J.; Ruthardt, Martin

Crizotinib is an allosteric ABL-inhibitor targeting both native BCR/ABL and BCR/ABL-T315I in vitro and in vivo models of PH plus leukemia

EUROPEAN JOURNAL OF CANCER

IF7.1

2014-07-01

PREAI

Mahajna, J.; Khamaisie, H.; Ruimi, N.; Agbarya, A.; Eshel, E.; Dally, N.; Ottmann, O.; Biondi, R.; Mian, A. A.; Ruthardt, M.

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

BMC CANCER

IF3.4

2012-11-27

OAAI

Khateb, Mamduh; Ruimi, Nili; Khamisie, Hazem; Najajreh, Yousef; Mian, Afsar; Metodieva, Anna; Ruthardt, Martin; Mahajna, Jamal

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

BMC CANCER

IF3.4

2012-09-17

OAAI

Mian, Afsar Ali; Metodieva, Anna; Badura, Susanne; Khateb, Mamduh; Ruimi, Nili; Najajreh, Yousef; Ottmann, Oliver Gerhard; Mahajna, Jamal; Ruthardt, Martin

The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells

CYTOTHERAPY

IF3.2

2012-01-01

105

PREAI

Rettinger, Eva; Kuci, Selim; Naumann, Ivonne; Becker, Petra; Kreyenberg, Hermann; Anzaghe, Martina; Willasch, Andre; Koehl, Ulrike; Bug, Gesine; Ruthardt, Martin; Klingebiel, Thomas; Fulda, Simone; Bader, Peter

The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation

LEUKEMIA

IF13.4

2010-09-09

PREAI

Oancea, C.; Ruester, B.; Henschler, R.; Puccetti, E.; Ruthardt, M.

研究方向