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Mechanistic Insights into the Adenosine A1 Receptor's Positive Allosteric Modulation for Non-Opioid Analgesics Weizmann, Tal; Pearce, Abigail; Griffin, Peter; Schild, Achille; Flasshoff, Maren; Grossenbacher, Philipp; Lochner, Martin; Reynolds, Christopher A.; Ladds, Graham; Deganutti, Giuseppe 分享 收藏
The circularly permuted globin domain of androglobin exhibits atypical heme stabilization and nitric oxide interaction Reeder, Brandon J.; Deganutti, Giuseppe; Ukeri, John; Atanasio, Silvia; Svistunenko, Dimitri A.; Ronchetti, Christopher; Mobarec, Juan Carlos; Welbourn, Elizabeth; Asaju, Jeffrey; Vos, Marten H.; Wilson, Michael T.; Reynolds, Christopher A. 分享 收藏
Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12 Ahonen, Tiina J.; Ng, Choa P.; Farinha, Beatriz; Almeida, Barbara; Victor, Bruno L.; Reynolds, Christopher; Kalso, Eija; Yli-Kauhaluoma, Jari; Greaves, Jennifer; Moreira, Vania M. 分享 收藏
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification 476,326个体中随机葡萄糖的gis提供了对糖尿病病理生理学，并发症和治疗分层的见解 Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; Gonzalez, Karla Sofia Gutierrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Magi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, He; Evangelou, Evangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Mueller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Correa, Ivan R., Jr.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, Andre G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Ines; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njolstad, Inger; Wichmann, H. -Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josee; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga 分享 收藏
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Understanding VPAC receptor family peptide binding and selectivity 了解VPAC受体家族肽的结合和选择性 Piper, Sarah J.; Deganutti, Giuseppe; Lu, Jessica; Zhao, Peishen; Liang, Yi-Lynn; Lu, Yao; Fletcher, Madeleine M.; Hossain, Mohammed Akhter; Christopoulos, Arthur; Reynolds, Christopher A.; Danev, Radostin; Sexton, Patrick M.; Wootten, Denise 分享 收藏
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Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression Wall, Mark J.; Hill, Emily; Huckstepp, Robert; Barkan, Kerry; Deganutti, Giuseppe; Leuenberger, Michele; Preti, Barbara; Winfield, Ian; Carvalho, Sabrina; Suchankova, Anna; Wei, Haifeng; Safitri, Dewi; Huang, Xianglin; Imlach, Wendy; La Mache, Circe; Dean, Eve; Hume, Cherise; Hayward, Stephanie; Oliver, Jess; Zhao, Fei-Yue; Spanswick, David; Reynolds, Christopher A.; Lochner, Martin; Ladds, Graham; Frenguelli, Bruno G. 分享 收藏
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The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation Winfield, Ian; Barkan, Kerry; Routledge, Sarah; Robertson, Nathan J.; Harris, Matthew; Jazayeri, Ali; Simms, John; Reynolds, Christopher A.; Poyner, David R.; Ladds, Graham 分享 收藏
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation Deganutti, Giuseppe; Liang, Yi-Lynn; Zhang, Xin; Khoshouei, Maryam; Clydesdale, Lachlan; Belousoff, Matthew J.; Venugopal, Hari; Truong, Tin T.; Glukhova, Alisa; Keller, Andrew N.; Gregory, Karen J.; Leach, Katie; Christopoulos, Arthur; Danev, Radostin; Reynolds, Christopher A.; Zhao, Peishen; Sexton, Patrick M.; Wootten, Denise 分享 收藏
Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist 部分激动可改善胃泌酸调节素衍生的GLP-1R/GCGR共激动剂的抗高血糖功效 Pickford, Phil; Lucey, Maria; Rujan, Roxana-Maria; McGlone, Emma Rose; Bitsi, Stavroula; Ashford, Fiona B.; Correa, Ivan R.; Hodson, David J.; Tomas, Alejandra; Deganutti, Giuseppe; Reynolds, Christopher A.; Owen, Bryn M.; Tan, Tricia M.; Minnion, James; Jones, Ben; Bloom, Stephen R. 分享 收藏
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Structure and dynamics of the active Gs-coupled human secretin receptor Dong, Maoqing; Deganutti, Giuseppe; Piper, Sarah J.; Liang, Yi-Lynn; Khoshouei, Maryam; Belousoff, Matthew J.; Harikumar, Kaleeckal G.; Reynolds, Christopher A.; Glukhova, Alisa; Furness, Sebastian G. B.; Christopoulos, Arthur; Danev, Radostin; Wootten, Denise; Sexton, Patrick M.; Miller, Laurence J. 分享 收藏
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