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张乐乐 封面图

张乐乐 (Lele Zhang)

Tongji University副研究员邮箱:liang_hu@sjtu.edu.cn
H指数:36
被引数:5,057

个人简介

聚焦于固有免疫调控与胸部慢性疾病免疫微环境研究，综合运用生物化学与分子生物学、细胞生物学、免疫学、生物信息学手段和疾病动物模型，研究固有免疫信号转导通路的新功能与新机制，阐释固有免疫信号通路在自身免疫性疾病、胸部慢性疾病以及肺癌免疫微环境中的功能与分子调控机理。近5年作为第一作者或通讯作者在Cancer Research、Genome Medicine、PLoS Pathogens等期刊发表研究论文多篇。

教育背景

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工作经历

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荣誉奖项

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Dynamic phenotyping of radioiodine-refractory differentiated thyroid cancer: thyroglobulin trajectories; dual-modal imaging; and genotype-defined treatment resistance

放射性碘难治性分化型甲状腺癌的动态表型分析：甲状腺球蛋白轨迹、双模态成像和基因型定义的治疗抵抗

Frontiers in Endocrinology
IF4.6
2026-08-110
OA
GT Gongxun Tan †; YZ Yue Zhang †; ZM Zhenwei Mao †; CZ Chuan Zhang; JF Jingjing Fu; FW Feng Wang; CZ Canhong Zhu; JZ Jin Zhou; BJ Bingquan Jin; YX Ying Xu; RQ Rong Qin; XS Xun Shao; LZ Lele Zhang; SL Shaohua Li; QG Qian Gu
Non-linear association between thyroid scintigraphy-derived thyroid weight and I-131 treatment efficacy in graves’ disease: a multicenter restricted cubic spline and threshold analysis

基于甲状腺闪烁扫描衍生的甲状腺重量与Graves’病I-131治疗疗效的非线性关联：一项多中心限制性立方样条和阈值分析

Frontiers in Endocrinology
IF4.6
2026-07-190
OAAI
LL Lu Lu †; LZ LeLe Zhang †; DM Dongyun Meng; XW Xiaojuan Wei; YC Yan Chen; SM Shaozhou Mo; ZS Zeyong Sun; FS Fengyang Song; YL Yuehua Li; XM Xingyu Mu; WH Wentan Huang; WF Wei Fu; KL Kehua Liao
Metabolic Modulation of Yogurt Fermentation Kinetics and Storage Stability by Lactobacillus-Starter Culture Interactions

期刊名称=Foods；作者=M An, Z Zhao, L Zhao, J Yang, H Gao, L Zhang, R Wang；卷号=14；发表日期=2025；页码=2935；DOI=10.3390/foods14172935；引用标识符=CR52

Foods
IF5.1
2026-03-030
OAAI
Meilun An; Zhi Zhao; Liang Zhao; Jianjun Yang; Haina Gao; Lele Zhang; Guoping Zhao; Baochao Hou; Jian He; Wei-Lian Hung; Baolei Li; Yangyang Yu; Shaoyang Ge; Xiaoxia Li; Ran Wang
Efficiency and safety of sintilimab-based induction therapy in potentially resectable stage III non-small cell lung cancer (LungMate-009): an open-label, phase 2 trial

基于sintilimab的诱导疗法在潜在可切除的III期非小细胞肺癌（LungMate-009）：一项开放标签、II期临床试验

eClinicalMedicine
IF10
2025-12-100
OAAI
Tao Ge; Hongyi Zhang; Xinsheng Zhu; Meixin Teng; Yifei Zhou; Suyu Wang; Dongliang Bian; Lele Zhang; Haiyang Hu; Qiji Guo; Jincheng Su; Shiqi Hu; Huansha Yu; Yirui Zhou; Jie Huang; Jie Yang; Yuming Zhu; Yi Bao; Minwei Bao; Xuefei Hu
Surgery after induced anti-PD-L1 therapy and chemotherapy for stage I‒III small-cell lung cancer: a phase 2 trial (LungMate-005)

诱导抗PD-L1治疗和化疗后对I‒III期小细胞肺癌进行手术：一项II期试验（LungMate-005）

Cell Discovery
IF12.5
2025-11-250
OAAI
Fenghuan Sun; Lele Zhang; Liangdong Sun; Di Wang; Nan Song; Liang Duan; Dongliang Bian; Junjie Hu; Yilv Yan; Jie Yang; Wenxin He; Yong Yang; Xiaogang Liu; Bin Chen; Jun Ma; Lixin Wang; Ming Liu; Xiaoxiong Xu; Cong Ye; Yirui Zhou; Huansha Yu; ZhaoXia Dai; Chang Chen; Deping Zhao; Jie Luo; Shuyan Meng; Gening Jiang; Peng Zhang
Fully automated volumetric assessment of tumor burden using artificial intelligence on 68Ga-PSMA-11 PET predicts survival after 177Lu-PSMA therapy in metastatic Castration-resistant prostate cancer

基于人工智能的68Ga-PSMA-11 PET全自动化肿瘤负荷体积评估可预测雄激素剥夺治疗抵抗性前列腺癌患者接受177Lu-PSMA疗法后的生存情况

European Journal of Nuclear Medicine and Molecular Imaging
IF7.6
2025-10-200
PRE
Shiming Zang; Qingle Meng; Xiaoyuan Li; Tiantian Guo; Lele Zhang; Zhenyu Zhao; Fei Yu; Pengjun Zhang; Wenyu Wu; Yudan Ni; Yuhang Shi; Guoqiang Shao; Youdan Feng; Lingzhi Hu; Ruipeng Jia; A. Cahid Civelek; Hongqian Guo; Feng Wang
Ubiquitin-Specific Protease 7-Mediated Stabilization of Discoidin Domain Receptor 1 Drives Progression of TP53-Mutant Cancers

泛素特异性蛋白酶7介导的 discsoidin 结构域受体1稳定化驱动TP53突变型癌症的进展

Journal of Biological Chemistry
IF3.9
2025-07-240
OA
Yiying Xue; Bing Xiu; Muye Yang; Yanwei Zhang; Changpeng Yang; Lele Zhang; Yilv Yan; Xiu Luo; Yushan Huang; Husheng Mei; Guiming Li; Lixin Zhou; Yisa Chen; Wenjun Zhang; Changlin Qian; Peng Zhang; Juan Liu; Aibin Liang; Yu Zeng; Jing Yang

研究方向

主要任职科研业绩
张鹏 封面图
张鹏
H 指数:52论文数:384被引数:1.1万
H
Huansha Yu
H 指数:20论文数:92被引数:2,310
韩
韩宝惠
H 指数:56论文数:712被引数:1.4万
L
Liangdong Sun
H 指数:13论文数:59被引数:2,252
J
Jun Lü
H 指数:34论文数:244被引数:3,987
Y
Yanwei Zhang
H 指数:26论文数:192被引数:2,916
王
王琛
H 指数:40论文数:106被引数:7,488
Y
Yilv Yan
H 指数:9论文数:47被引数:1,926
J
Junjie Hu
H 指数:11论文数:49被引数:755
D
Dongliang Bian
H 指数:11论文数:56被引数:836