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J

Julien Chapuis

univ. lille and inserm and chu lille and institut pasteur de lille
H指数:24
被引数:4,422

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PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

PLCγ2下调损害突触功能并增加神经元培养物中的阿尔茨海默病标志物

Nature Genetics
IF29
2026-08-140
OA
Audrey Coulon; Florian Rabiller; Mari Takalo; Avishek Roy; Alexandre Pelletier; Henna Martiskainen; Dolores Siedlecki-Wullich; Nina Lannette-Weimann; Naďa Majerníková; Arthur Grenon; Vance Gao; Anaël Erhardt; Anne Pernodet; Morgane Lemaire; Floriane Limoge; Pauline Walle; Tiago Mendes; Karine Guyot; Célia Lemeu; Lukas-Iohan Carvalho; Ana Raquel Melo de Farias; Marc Hulsman; Chloé Najdek; Alejandra Freire-Regatillo; Orthis Saha; Philippe Amouyel; Camille Charbonnier; Jean-François Deleuze; Orio Dols-Icardo; Heli Jeskanen; Roosa-Maria Willman; Teemu Kuulasmaa; Mitja Kurki; John Hardy; Sami Heikkinen; Henne Holstege; Petra Mäkinen; Gaël Nicolas; Simon Mead; Michael Wagner; Alfredo Ramirez; Tuomas Rauramaa; Aarno Palotie; Rebecca Sims; Hilkka Soininen; John van Swieten; Julie Williams; Céline Bellenguez; Carla Gelle; Erwan Lambert; Marcos R. Costa; Julia TCW; Enrico Glaab; Anne-Marie Ayral; Florie Demiautte; Benjamin Grenier-Boley; Manon Muntaner; Delphine Eberlé; Séverine Deforges; Joel T. Haas; Devrim Kilinc; Christophe Mulle; Julien Chapuis; Mikko Hiltunen; Julie Dumont; Jean-Charles Lambert
New insights into the genetic etiology of Alzheimer's disease and related dementias

对阿尔茨海默氏病和相关痴呆症的遗传病因的新见解

NATURE GENETICS
IF31.8
2022-04-04919
OAAI
Bellenguez, Celine; Kucukali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; De Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcon-Martin, Emilio; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Alvarez, Victoria; Armstrong, Nicola J.; Tsolaki, Anthoula; Antunez, Carmen; Appollonio, Ildebrando; Arcaro, Marina; Archetti, Silvana; Arias Pastor, Alfonso; Arosio, Beatrice; Athanasiu, Lavinia; Bailly, Henri; Banaj, Nerisa; Baquero, Miquel; Barral, Sandra; Beiser, Alexa; Pastor, Ana Belen; Below, Jennifer E.; Benchek, Penelope; Benussi, Luisa; Berr, Claudine; Besse, Celine; Bessi, Valentina; Binetti, Giuliano; Bizarro, Alessandra; Blesa, Rafael; Boada, Merce; Boerwinkle, Eric; Borroni, Barbara; Boschi, Silvia; Bossu, Paola; Brathen, Geir; Bressler, Jan; Bresner, Catherine; Brodaty, Henry; Brookes, Keeley J.; Ignacio Brusco, Luis; Buiza-Rueda, Dolores; Burger, Katharina; Burholt, Vanessa; Bush, William S.; Calero, Miguel; Cantwell, Laura B.; Chene, Genevieve; Chung, Jaeyoon; Cuccaro, Michael L.; Cecchetti, Roberta; Cervera-Carles, Laura; Charbonnier, Camille; Chen, Hung-Hsin; Chillotti, Caterina; Ciccone, Simona; Claassen, Jurgen A. H. R.; Clark, Christopher; Conti, Elisa; Corma-Gomez, Anais; Costantini, Emanuele; Custodero, Carlo; Daian, Delphine; Dalmasso, Maria Carolina; Daniele, Antonio; Dardiotis, Efthimios; Dartigues, Jean-Francois; de Deyn, Peter Paul; Lopes, Katia de Paiva; De Witte, Lot D.; Debette, Stephanie; Deckert, Jurgen; del Ser, Teodoro; Denning, Nicola; Destefano, Anita; Dichgans, Martin; Diehl-Schmid, Janine; Diez-Fairen, Monica; Rossi, Paolo Dionigi; Djurovic, Srdjan; Duron, Emmanuelle; Duzel, Emrah; Dufouil, Carole; Eiriksdottir, Gudny; Engelborghs, Sebastiaan; Escott-Price, Valentina; Espinosa, Ana; Ewers, Michael; Faber, Kelley M.; Fabrizio, Tagliavini; Nielsen, Sune Fallgaard; Fardo, David W.; Farotti, Lucia; Fenoglio, Chiara; Fernandez-Fuertes, Marta; Ferrari, Raffaele; Ferreira, Catarina B.; Ferri, Evelyn; Fin, Bertrand; Fischer, Peter; Fladby, Tormod; Fliessbach, Klaus; Fongang, Bernard; Fornage, Myriam; Fortea, Juan; Foroud, Tatiana M.; Fostinelli, Silvia; Fox, Nick C.; Franco-Macias, Emlio; Bullido, Maria J.; Frank-Garcia, Ana; Froelich, Lutz; Fulton-Howard, Brian; Galimberti, Daniela; Maria Garcia-Alberca, Jose; Garcia-Madrona, Sebastian; Garcia-Ribas, Guillermo; Ghidoni, Roberta; Giegling, Ina; Giorgio, Giaccone; Goate, Alison M.; Goldhardt, Oliver; Gomez-Fonseca, Duber; Gonzalez-Perez, Antonio; Graff, Caroline; Grande, Giulia; Green, Emma; Grimmer, Timo; Grunblatt, Edna; Grunin, Michelle; Gudnason, Vilmundur; Guetta-Baranes, Tamar; Haapasalo, Annakaisa; Hadjigeorgiou, Georgios; Haines, Jonathan L.; Hamilton-Nelson, Kara L.; Hampel, Harald; Hanon, Olivier; Hardy, John; Hartmann, Annette M.; Hausner, Lucrezia; Harwood, Janet; Heilmann-Heimbach, Stefanie; Helisalmi, Seppo; Heneka, Michael T.; Hernandez, Isabel; Herrmann, Martin J.; Hoffmann, Per; Holmes, Clive; Holstege, Henne; Huerto Vilas, Raquel; Hulsman, Marc; Humphrey, Jack; Biessels, Geert Jan; Jian, Xueqiu; Johansson, Charlotte; Jun, Gyungah R.; Kastumata, Yuriko; Kauwe, John; Kehoe, Patrick G.; Kilander, Lena; Stahlbom, Anne Kinhult; Kivipelto, Miia; Koivisto, Anne; Kornhuber, Johannes; Kosmidis, Mary H.; Kukull, Walter A.; Kuksa, Pavel P.; Kunkle, Brian W.; Kuzma, Amanda B.; Lage, Carmen; Laukka, Erika J.; Launer, Lenore; Lauria, Alessandra; Lee, Chien-Yueh; Lehtisalo, Jenni; Lerch, Ondrej; Lleo, Alberto; Longstreth, William, Jr.; Lopez, Oscar; Lopez de Munain, Adolfo; Love, Seth; Lowemark, Malin; Luckcuck, Lauren; Lunetta, Kathryn L.; Ma, Yiyi; Macias, Juan; Macleod, Catherine A.; Maier, Wolfgang; Mangialasche, Francesca; Spallazzi, Marco; Marquie, Marta; Marshall, Rachel; Martin, Eden R.; Martin Montes, Angel; Martinez Rodriguez, Carmen; Masullo, Carlo; Mayeux, Richard; Mead, Simon; Mecocci, Patrizia; Medina, Miguel; Meggy, Alun; Mehrabian, Shima; Mendoza, Silvia; Menendez-Gonzalez, Manuel; Mir, Pablo; Moebus, Susanne; Mol, Merel; Molina-Porcel, Laura; Montrreal, Laura; Morelli, Laura; Moreno, Fermin; Morgan, Kevin; Mosley, Thomas; Nothen, Markus M.; Muchnik, Carolina; Mukherjee, Shubhabrata; Nacmias, Benedetta; Ngandu, Tiia; Nicolas, Gael; Nordestgaard, Borge G.; Olaso, Robert; Orellana, Adelina; Orsini, Michela; Ortega, Gemma; Padovani, Alessandro; Paolo, Caffarra; Papenberg, Goran; Parnetti, Lucilla; Pasquier, Florence; Pastor, Pau; Peloso, Gina; Perez-Cordon, Alba; Perez-Tur, Jordi; Pericard, Pierre; Peters, Oliver; Pijnenburg, Yolande A. L.; Pineda, Juan A.; Pinol-Ripoll, Gerard; Pisanu, Laudia; Polak, Thomas; Popp, Julius; Posthuma, Danielle; Priller, Josef; Puerta, Raquel; Quenez, Olivier; Quintela, Ines; Thomassen, Jesper Qvist; Rabano, Alberto; Rainero, Innocenzo; Rajabli, Farid; Ramakers, Inez; Real, Luis M.; Reinders, Marcel J. T.; Reitz, Christiane; Reyes-Dumeyer, Dolly; Ridge, Perry; Riedel-Heller, Steffi; Riederer, Peter; Roberto, Natalia; Rodriguez-Rodriguez, Eloy; Rongve, Arvid; Rosas Allende, Irene; Rosende-Roca, Maitee; Luis Royo, Jose; Rubino, Elisa; Rujescu, Dan; Eugenia Saez, Maria; Sakka, Paraskevi; Saltvedt, Ingvild; Bernal Sanchez-Arjona, Maria; Sanchez-Garcia, Florentino; Sanchez Juan, Pascual; Sanchez-Valle, Raquel; Sando, Sigrid B.; Sarnowski, Chloe; Satizabal, Claudia L.; Scamosci, Michela; Scarmeas, Nikolaos; Scarpini, Elio; Scheltens, Philip; Scherbaum, Norbert; Scherer, Martin; Schmid, Matthias; Schneider, Anja; Schott, Jonathan M.; Selbaek, Geir; Seripa, Davide; Serrano, Manuel; Sha, Jin; Shadrin, Alexey A.; Skrobot, Olivia; Slifer, Susan; Snijders, Gijsje J. L.; Soininen, Hilkka; Solfrizzi, Vincenzo; Solomon, Alina; Song, Yeunjoo; Sorbi, Sandro; Sotolongo-Grau, Oscar; Spalletta, Gianfranco; Spottke, Annika; Squassina, Alessio; Stordal, Eystein; Pablo Tartan, Juan; Tarraga, Lluis; Tesi, Niccolo; Thalamuthu, Anbupalam; Thomas, Tegos; Tosto, Giuseppe; Traykov, Latchezar; Tremolizzo, Lucio; Tybjaerg-Hansen, Anne; Uitterlinden, Andre; Ullgren, Abbe; Ulstein, Ingun; Valero, Sergi; Valladares, Otto; Van Broeckhoven, Christine; Vance, Jeffery; Vardarajan, Badri N.; van der Lugt, Aad; Van Dongen, Jasper; van Rooij, Jeroen; van Swieten, John; Vandenberghe, Rik; Verhey, Frans; Vidal, Jean-Sebastien; Vogelgsang, Jonathan; Vyhnalek, Martin; Wagner, Michael; Wallon, David; Wang, Li-San; Wang, Ruiqi; Weinhold, Leonie; Wiltfang, Jens; Windle, Gill; Woods, Bob; Yannakoulia, Mary; Zare, Habil; Zhao, Yi; Zhang, Xiaoling; Zhu, Congcong; Zulaica, Miren; Farrer, Lindsay A.; Psaty, Bruce M.; Ghanbari, Mohsen; Raj, Towfique; Sachdev, Perminder; Mather, Karen; Jessen, Frank; Ikram, M. Arfan; de Mendonca, Alexandre; Hort, Jakub; Tsolaki, Magda; Pericak-Vance, Margaret A.; Amouyel, Philippe; Williams, Julie; Frikke-Schmidt, Ruth; Clarimon, Jordi; Deleuze, Jean-Francois; Rossi, Giacomina; Seshadri, Sudha; Andreassen, Ole A.; Ingelsson, Martin; Hiltunen, Mikko; Sleegers, Kristel; Schellenberg, Gerard D.; van Duijn, Cornelia M.; Sims, Rebecca; van der Flier, Wiesje M.; Ruiz, Agustin; Ramirez, Alfredo; Lambert, Jean-Charles
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects
ACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
2022-01-0831
OAAI
Lambert, Erwan; Saha, Orthis; Landeira, Bruna Soares; de Farias, Ana Raquel Melo; Hermant, Xavier; Carrier, Arnaud; Pelletier, Alexandre; Gadaut, Johanna; Davoine, Lindsay; Dupont, Cloe; Amouyel, Philippe; Bonnefond, Amelie; Lafont, Frank; Abdelfettah, Farida; Verstreken, Patrik; Chapuis, Julien; Barois, Nicolas; Delahaye, Fabien; Dermaut, Bart; Lambert, Jean-Charles; Costa, Marcos R.; Dourlen, Pierre
Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells
SCIENCE ADVANCES
IF12.5
2021-05-0710
OAAI
Kerselidou, Despoina; Dohai, Bushra Saeed; Nelson, David R.; Daakour, Sarah; De Cock, Nicolas; Hassoun, Zahra Al Oula; Kim, Dae-Kyum; Olivet, Julien; El Assal, Diana C.; Jaiswal, Ashish; Alzahmi, Amnah; Saha, Deeya; Pain, Charlotte; Matthijssens, Filip; Lemaitre, Pierre; Herfs, Michael; Chapuis, Julien; Ghesquiere, Bart; Vertommen, Didier; Kriechbaumer, Verena; Knoops, Kevin; Lopez-Iglesias, Carmen; van Zandvoort, Marc; Lambert, Jean-Charles; Hanson, Julien; Desmet, Christophe; Thiry, Marc; Lauersen, Kyle J.; Vidal, Marc; Van Vlierberghe, Pieter; Dequiedt, Franck; Salehi-Ashtiani, Kourosh; Twizere, Jean-Claude
Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner (Nov, 10.1038/s41380-020-00926-w, 2020)
MOLECULAR PSYCHIATRY
IF10.1
2021-01-042
OAAI
Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Vreulx, Anais-Camille; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Checler, Frederic; Farinelli, Melissa; Delay, Charlotte; Malmanche, Nicolas; Hebert, Sebastien S.; Dumont, Julie; Kilinc, Devrim; Lambert, Jean-Charles; Chapuis, Julien
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation
ACTA NEUROPATHOLOGICA
IF9.3
2019-05-0738
OAAI
Sartori, Maxime; Mendes, Tiago; Desai, Shruti; Lasorsa, Alessia; Herledan, Adrien; Malmanche, Nicolas; Makinen, Petra; Marttinen, Mikael; Malki, Idir; Chapuis, Julien; Flaig, Amandine; Vreulx, Anais-Camille; Ciancia, Marion; Amouyel, Philippe; Leroux, Florence; Deprez, Benoit; Cantrelle, Francois-Xavier; Marechal, Damien; Pradier, Laurent; Hiltunen, Mikko; Landrieu, Isabelle; Kilinc, Devrim; Herault, Yann; Laporte, Jocelyn; Lambert, Jean-Charles
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

全基因组高含量siRNA筛选确定阿尔茨海默氏症遗传危险因子FERMT2是APP代谢的主要调节剂

ACTA NEUROPATHOLOGICA
IF9.3
2016-12-0845
OAAI
Chapuis, Julien; Flaig, Amandine; Grenier-Boley, Benjamin; Eysert, Fanny; Pottiez, Virginie; Deloison, Gaspard; Vandeputte, Alexandre; Ayral, Anne-Marie; Mendes, Tiago; Desai, Shruti; Goate, Alison M.; Kauwe, John S. K.; Leroux, Florence; Herledan, Adrien; Demiautte, Florie; Bauer, Charlotte; Checler, Frederic; Petersen, Ronald C.; Blennow, Kaj; Zetterberg, Henrik; Minthon, Lennart; Van Deerlin, Vivianna M.; Lee, Virginia Man-Yee; Shaw, Leslie M.; Trojanowski, John Q.; Albert, Marilyn; Moghekar, Abhay; O'Brien, Richard; Peskind, Elaine R.; Malmanche, Nicolas; Schellenberg, Gerard D.; Dourlen, Pierre; Song, Ok-Ryul; Cruchaga, Carlos; Amouyel, Philippe; Deprez, Benoit; Brodin, Priscille; Lambert, Jean-Charles
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease
EBIOMEDICINE
IF10.8
2016-07-0139
OAAI
Letronne, Florent; Laumet, Geoffroy; Ayral, Anne-Marie; Chapuis, Julien; Demiautte, Florie; Laga, Mathias; Vandenberghe, Michel E.; Malmanche, Nicolas; Leroux, Florence; Eysert, Fanny; Sottejeau, Yoann; Chami, Linda; Flaig, Amandine; Bauer, Charlotte; Dourlen, Pierre; Lesaffre, Marie; Delay, Charlotte; Huot, Ludovic; Dumont, Julie; Werkmeister, Elisabeth; Lafont, Franck; Mendes, Tiago; Hansmannel, Franck; Dermaut, Bart; Deprez, Benoit; Herard, Anne-Sophie; Dhenain, Marc; Souedet, Nicolas; Pasquier, Florence; Tulasne, David; Berr, Claudine; Hauw, Jean-Jacques; Lemoine, Yves; Amouyel, Philippe; Mann, David; Deprez, Rebecca; Checler, Frederic; Hot, David; Delzescaux, Thierry; Gevaert, Kris; Lambert, Jean-Charles
Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain
ACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
2015-09-2366
OAAI
Sottejeau, Yoann; Bretteville, Alexis; Cantrelle, Francois-Xavier; Malmanche, Nicolas; Demiaute, Florie; Mendes, Tiago; Delay, Charlotte; Dos Alves, Harmony Alves; Flaig, Amandine; Davies, Peter; Dourlen, Pierre; Dermaut, Bart; Laporte, Jocelyn; Amouyel, Philippe; Lippens, Guy; Chapuis, Julien; Landrieu, Isabelle; Lambert, Jean-Charles
A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly
MOLECULAR PSYCHIATRY
IF10.1
2014-02-1831
OAAI
Chouraki, V.; De Bruijn, R. F. A. G.; Chapuis, J.; Bis, J. C.; Reitz, C.; Schraen, S.; Ibrahim-Verbaas, C. A.; Grenier-Boley, B.; Delay, C.; Rogers, R.; Demiautte, F.; Mounier, A.; Fitzpatrick, A. L.; Berr, C.; Dartigues, J-F; Uitterlinden, A. G.; Hofman, A.; Breteler, M.; Becker, J. T.; Lathrop, M.; Schupf, N.; Alperovitch, A.; Mayeux, R.; van Duijn, C. M.; Buee, L.; Amouyel, P.; Lopez, O. L.; Ikram, M. A.; Tzourio, C.; Lambert, J-C
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
MOLECULAR PSYCHIATRY
IF10.1
2013-02-12317
OAAI
Chapuis, J.; Hansmannel, F.; Gistelinck, M.; Mounier, A.; Van Cauwenberghe, C.; Kolen, K. V.; Geller, F.; Sottejeau, Y.; Harold, D.; Dourlen, P.; Grenier-Boley, B.; Kamatani, Y.; Delepine, B.; Demiautte, F.; Zelenika, D.; Zommer, N.; Hamdane, M.; Bellenguez, C.; Dartigues, J-F; Hauw, J-J; Letronne, F.; Ayral, A-M; Sleegers, K.; Schellens, A.; Broeck, L. V.; Engelborghs, S.; De Deyn, P. P.; Vandenberghe, R.; O'Donovan, M.; Owen, M.; Epelbaum, J.; Mercken, M.; Karran, E.; Bantscheff, M.; Drewes, G.; Joberty, G.; Campion, D.; Octave, J-N; Berr, C.; Lathrop, M.; Callaerts, P.; Mann, D.; Williams, J.; Buee, L.; Dewachter, I.; Van Broeckhoven, C.; Amouyel, P.; Moechars, D.; Dermaut, B.; Lambert, J-C

研究方向

暂未获取到该数据
J
Jean‐Charles Lambert
H 指数:85论文数:530被引数:4.1万
A
Amouyel, Philippe
H 指数:0论文数:22被引数:474
P
Pierre Dourlen
H 指数:21论文数:50被引数:2,074
T
Tiago Mendes
H 指数:21论文数:74被引数:2,309
B
Bart Dermaut
H 指数:44论文数:138被引数:7,930
F
Florence Pasquier
H 指数:101论文数:955被引数:7.2万
D
Devrim Kilinc
H 指数:22论文数:69被引数:1,486
B
Benjamin Grenier‐Boley
H 指数:41论文数:139被引数:2.0万
F
Florie Demiautte
H 指数:7论文数:32被引数:755
N
Nicolas Malmanche
H 指数:14论文数:35被引数:944