未登录 Altered Inflammatory Signature in a C9ORF72-ALS iPSC-Derived Motor Neuron and Microglia Coculture Model C9ORF72-ALS iPSC来源的运动神经元和微胶质细胞共培养模型中的炎症特征改变 Gao, Yujing; Brothwood, Jessica L.; Saini, Harpreet; O'Sullivan, Gregory A.; Bento, Carla F.; McCarthy, James M.; Wallis, Nicola G.; Di Daniel, Elena; Graham, Brent; Tams, Daniel M. 分享 收藏
Replenishing co-downregulated miR-100-5p and miR-125b-5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption Ferraresso, Marta; Bailey, Shivani; Alonso-Crisostomo, Luz; Ward, Dawn; Panayi, Christos; Scurlock, Zachary G. L.; Saini, Harpreet K.; Smith, Stephen P.; Nicholson, James C.; Enright, Anton J.; Scarpini, Cinzia G.; Coleman, Nicholas; Murray, Matthew J. 分享 收藏
The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1 GBA1的注释已被其蛋白质编码假基因GBAP1所掩盖 Gustavsson, Emil K.; Sethi, Siddharth; Gao, Yujing; Brenton, Jonathan W.; Garcia-Ruiz, Sonia; Zhang, David; Garza, Raquel; Reynolds, Regina H.; Evans, James R.; Chen, Zhongbo; Grant-Peters, Melissa; Macpherson, Hannah; Montgomery, Kylie; Dore, Rhys; Wernick, Anna I.; Arber, Charles; Wray, Selina; Gandhi, Sonia; Esselborn, Julian; Blauwendraat, Cornelis; Douse, Christopher H.; Adami, Anita; Atacho, Diahann A. M.; Kouli, Antonina; Quaegebeur, Annelies; Barker, Roger A.; Englund, Elisabet; Platt, Frances; Jakobsson, Johan; Wood, Nicholas W.; Houlden, Henry; Saini, Harpreet; Bento, Carla F.; Hardy, John; Ryten, Mina 分享 收藏
Identification of biomarkers of response to MDM2 inhibition in solid tumours using computational, multi-omics approaches Saini, Harpreet Kaur; Ahn, Maria; Ward, George; Kucia-Tran, Justyna; Gewinner, Christina; Ferrari, Nicola; Brothwood, Jessica; Bevan, Luke; Davis, Matthew; Fazal, Lynsey; Sims, Martin; O'Reilly, Marc; Chessari, Gianni; Ferraldeschi, Roberta; Lyons, John; Wallis, Nicola; Thompson, Neil 分享 收藏
Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile Ahn, Maria; Bevan, Luke; Buck, Ildiko; Cano, Celine; Castro, Juan; Cons, Ben; Endicott, Jane; Fazal, Lynsey; Ferrari, Nicola; Hardcastle, Ian; Hearn, Keisha; Holvey, Rhian; Howard, Steven; Johnson, Chris; Jennings, Claire; Kucia-Tran, Justyna; Kyle, Suzanne; Lunec, John; Lyons, John; Miller, Duncan; Rees, David; Noble, Martin; Newell, David R.; Reeks, Judith; Saini, Harpreet; Denis, Jeffrey St.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil; Vinkovic, Mladen; Ward, George; Wallis, Nicola; Walton, Hugh; Wedge, Stephen; Williams, Pamela; Willmore, Elaine; Wilshire, Nicola; Zhao, Yan; Chessari, Gianni 分享 收藏
Identifying sensitive patient populations for CDK7 inhibitors using cell panel screens and bioinformatic approaches Hearn, Keisha; Ahn, Maria; Bevan, Luke; Brothwood, Jessica; East, Charlotte; Esteve-Arneys, Anna; Fazal, Lynsey; Hindely, Christopher; James, Sabrina; Kucia-Tran, Justyna; Lyons, John; Munck, Joanne; Saini, Harpreet; Unbekandt, Mathieu; Varshney, Dhaval; Wagner, Steve; Woodhead, Andrew; Wallis, Nicola 分享 收藏
Targeting oncogenic microRNAs from the miR-371∼373 and miR-302/367 clusters in malignant germ cell tumours causes growth inhibition through cell cycle disruption (vol 129, pg 1451, 2023) Bailey, Shivani; Ferraresso, Marta; Alonso-Crisostomo, Luz; Ward, Dawn; Smith, Stephen; Nicholson, James C.; Saini, Harpreet; Enright, Anton J.; Scarpini, Cinzia G.; Coleman, Nicholas; Murray, Matthew J. 分享 收藏
Targeting oncogenic microRNAs from the miR-371∼373 and miR-302/267 clusters in malignant germ cell tumours causes growth inhibition through cell cycle disruption Bailey, Shivani; Ferraresso, Marta; Alonso-Crisostomo, Luz; Ward, Dawn; Smith, Stephen; Nicholson, James C.; Saini, Harpreet; Enright, Anton J.; Scarpini, Cinzia G.; Coleman, Nicholas; Murray, Matthew J. 分享 收藏
Small non-coding RNA sequencing reveals global dysregulation of piwi-interacting RNA (piRNA) expression in gonadal malignant germ cell tumours Laidlaw, Sean; Alonso-Crisostomo, Luz; Bailey, Shivani; Saini, Harpreet K.; Molnar, Attila; Nicholson, James C.; Enright, Anton J.; Scarpini, Cinzia G.; Rahbari, Raheleh; Coleman, Nicholas; Murray, Matthew J. 分享 收藏
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Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma Ferrari, Nicola; Ward, George; Gewinner, Christina; Davis, Matthew P.; Jueliger, Simone; Saini, Harpreet; Munck, Joanne; Smyth, Tomoko; Ferraldeschi, Roberta; Keer, Harold; Lyons, John; Sims, Martin J. 分享 收藏
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Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2 Kidger, Andrew M.; Munck, Joanne M.; Saini, Harpreet K.; Balmanno, Kathryn; Minihane, Emma; Courtin, Aurelie; Graham, Brent; O'Reilly, Marc; Odle, Richard; Cook, Simon J. 分享 收藏
Visualization and analysis of RNA-Seq assembly graphs Nazarie, Fahmi W.; Shih, Barbara; Angus, Tim; Barnett, Mark W.; Chen, Sz-Hau; Summers, Kim M.; Klein, Karsten; Faulkner, Geoffrey J.; Saini, Harpreet K.; Watson, Mick; van Dongen, Stijn; Enright, Anton J.; Freeman, Tom C. 分享 收藏
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Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2 Heightman, Tom D.; Berdini, Valerio; Braithwaite, Hannah; Buck, Ildiko M.; Cassidy, Megan; Castro, Juan; Courtin, Aurelie; Day, James E. H.; East, Charlotte; Fazal, Lynsey; Graham, Brent; Griffiths-Jones, Charlotte M.; Lyons, John F.; Martins, Vanessa; Muench, Sandra; Munck, Joanne M.; Norton, David; O'Reilly, Marc; Palmer, Nick; Pathuri, Puja; Reader, Michael; Rees, David C.; Rich, Sharna J.; Richardson, Caroline; Saini, Harpreet; Thompson, Neil T.; Wallis, Nicola G.; Walton, Hugh; Wilsher, Nicola E.; Woolford, Alison J. -A.; Cooke, Michael; Cousin, David; Onions, Stuart; Shannon, Jonathan; Watts, John; Murray, Christopher W. 分享 收藏
Fragment-based discovery of a highly potent, orally bioavailable ERK1/2 inhibitor that modulates the phosphorylation and catalytic activity of ERK1/2 Heightman, Tom D.; Berdini, Valerio; Braithwaite, Hannah; Buck, Ildiko; Cassidy, Megan; Castro, Juan; Courtin, Aurelie; Day, James; East, Charlotte; Fazal, Lynsey; Graham, Brent; Griffiths-Jones, Charlotte; Lyons, John; Martins, Vanessa; Muench, Sandra; Munck, Joanne; Norton, David; O'Reilly, Marc; Palmer, Nick; Pathuri, Puja; Reader, Mike; Rees, David; Rich, Sharna; Richardson, Caroline; Saini, Harpreet; Thompson, Neil; Wallis, Nicola; Walton, Hugh; Wilsher, Nicola; Woolford, Alison; Murray, Chris 分享 收藏
Characterization of a novel ERK1/2 inhibitor, which modulates the phosphorylation and catalytic activity of ERK1/2 Munck, Joanne M.; Berdini, Valerio; Bevan, Luke D.; Braithwaite, Hannah; Buck, Ildiko M.; Cassidy, Megan; Castro, Juan; Courtin, Aurelie; Day, James E.; East, Charlotte; Fazal, Lynsey; Graham, Brent; Griffiths-Jones, Charlotte M.; Heightman, Tom D.; Hindley, Chris J.; Kidane, Birikiti; Kucia-Tran, Justyna; Lyons, John F.; Martins, Vanessa; Muench, Sandra; Murray, Chris W.; Norton, David; O'Reilly, Marc; Palmer, Nick; Pathuri, Puja; Reader, Mike; Rees, David C.; Rich, Sharna J.; Richardson, Caroline J.; Saini, Harpreet K.; Shah, Alpesh; Stanczuk, Lukas; Thompson, Neil T.; Walton, Hugh; Wilsher, Nicola E.; Woolford, Alison J.; Wallis, Nicola G. 分享 收藏
Extracellular vesicles are independent metabolic units with asparaginase activity 细胞外囊泡是具有天冬酰胺酶活性的独立代谢单位 Iraci, Nunzio; Gaude, Edoardo; Leonardi, Tommaso; Costa, Ana S. H.; Cossetti, Chiara; Peruzzotti-Jametti, Luca; Bernstock, Joshua D.; Saini, Harpreet K.; Gelati, Maurizio; Vescovi, Angelo Luigi; Bastos, Carlos; Faria, Nuno; Occhipinti, Luigi G.; Enright, Anton J.; Frezza, Christian; Pluchino, Stefano 分享 收藏
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