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S

Somnath Mahapatra

university of michigan
H指数:18
被引数:1,371

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Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer

通过p300/CBP降解靶向前列腺癌中乙酰化的H2B组蛋白增强子复合物

Nature Genetics
IF29
2025-10-030
OAAI
Jie Luo; Zhixiang Chen; Yuanyuan Qiao; Jean Ching-Yi Tien; Eleanor Young; Rahul Mannan; Somnath Mahapatra; Rupam Bhattacharyya; Lanbo Xiao; Tongchen He; Sanjana Eyunni; Yuping Zhang; Yang Zheng; Fengyun Su; Xuhong Cao; Rui Wang; Yunhui Cheng; Rithvik Seri; James George; Miriam Shahine; Stephanie J. Miner; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Ulka Vaishampayan; Mi Wang; Shaomeng Wang; Abhijit Parolia; Arul M. Chinnaiyan
CDK12/13 inactivation triggers STING-mediated antitumor immunity in preclinical models

CDK12/13失活触发STING介导的抗肿瘤免疫在临床前模型中

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-09-160
OA
Bao, Yi; Chang, Yu; Tien, Jean Ching-Yi; Cruz, Gabriel; Yang, Fan; Mannan, Rahul; Mahapatra, Somnath; Paturu, Radha; Cao, Xuhong; Su, Fengyun; Wang, Rui; Zhang, Yuping; Gondal, Mahnoor; Choi, Jae eun; Gurkan, Jonathan K.; Miner, Stephanie J.; Robinson, Dan R.; Wu, Yi-Mi; Zhou, Licheng; Wang, Zhen; Kryczek, Ilona; Wang, Xiaoju; Cieslik, Marcin; Qiao, Yuanyuan; Tsodikov, Alexander; Zou, Weiping; Ding, Ke; Chinnaiyan, Arul M.
TRIM63 Overexpression in FISH-Negative MiTF Family Altered Renal Cell Carcinoma (MiTF RCC)

TRIM63在FISH阴性MiTF家族改变的肾细胞癌（MiTF RCC）中的过表达

Modern Pathology
IF5.5
2025-08-250
PREAI
Rahul Mannan; Ying-Bei Chen; Xiaoming Wang; Yuping Zhang; Noshad Hosseini; Ankur R. Sangoi; Andres Acosta; Sean R. Williamson; Somnath Mahapatra; Anya K. Chinnaiyan; Jing Hu; Ulka Vaishampayan; Lina Shao; Bryan L. Betz; Annette S. Kim; Xuhong Cao; Fengyun Su; Rui Wang; Pedram Argani; Noah Brown; Satish K. Tickoo; Arul M. Chinnaiyan; Victor E. Reuter; Saravana M. Dhanasekaran; Rohit Mehra
Discovery of YJZ5118: A Potent and Highly Selective Irreversible CDK12/13 Inhibitor with Synergistic Effects in Combination with Akt Inhibition

YJZ5118的发现：一种具有协同效应的强效且高度选择性的不可逆CDK12/13抑制剂，可与Akt抑制联合用药。

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-03-130
PRE
Yang, Jianzhang; Chang, Yu; Zhou, Kaijie; Huang, Weixue; Tien, Jean Ching-Yi; Zhang, Pujuan; Liu, Wenyan; Zhou, Licheng; Zhou, Yang; Ren, Xiaomei; Mannan, Rahul; Mahapatra, Somnath; Zhang, Yuping; Hamadeh, Rudana; Ervine, Grafton; Wang, Zhen; Wang, George Xiaoju; Chinnaiyan, Arul M.; Ding, Ke
Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity

不同的FOXA1突变驱动前列腺肿瘤发生和治疗抵抗性细胞可塑性

Science
IF45.8
2025-01-010
OA
Sanjana Eyunni; Rahul Mannan; Yuping Zhang; Eleanor Young; Qiuyang Zhang; Jie Luo; Matthew Pang; Somnath Mahapatra; Jean Ching-Yi Tien; James M. George; Mustapha Jaber; Hamzah Hakkani; Sandra E. Carson; Abigail J. Todd; Noshad Hosseini; Mahnoor Naseer Gondal; Ryan James Rebernick; Xuhong Cao; Fengyun Su; Rui Wang; Rohit Mehra; Jing Li; Marcin P. Cieslik; Arul M. Chinnaiyan; Abhijit Parolia
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

开发口服生物可利用的CDK12/13降解剂并通过AKT途径抑制诱导合成致死率

CELL REPORTS
IF6.9
2024-10-011
OAAI
Chang, Yu; Wang, Xiaoju; Yang, Jianzhang; Tien, Jean Ching-Yi; Mannan, Rahul; Cruz, Gabriel; Zhang, Yuping; Vo, Josh N.; Magnuson, Brian; Mahapatra, Somnath; Cho, Hanbyul; Dhanasekaran, Saravana Mohan; Wang, Cynthia; Wang, Zhen; Zhou, Licheng; Zhou, Kaijie; Zhou, Yang; Zhang, Pujuan; Huang, Weixue; Xiao, Lanbo; Liu, Weihuang Raymond; Hamadeh, Rudana; Su, Fengyun; Wang, Rui; Miner, Stephanie J.; Cao, Xuhong; Cheng, Yunhui; Mehra, Rohit; Ding, Ke; Chinnaiyan, Arul M.
CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13
CELL REPORTS MEDICINE
IF10.6
2024-10-010
OAAI
Tien, Jean Ching-Yi; Luo, Jie; Chang, Yu; Zhang, Yuping; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Mahapatra, Somnath; Shah, Palak; Wang, Xiao-Ming; Todd, Abigail J.; Eyunni, Sanjana; Cheng, Caleb; Rebernick, Ryan J.; Xiao, Lanbo; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen J.; Cao, Xuhong; Miner, Stephanie J.; Zhou, Licheng; Wu, Yi-Mi; Labanca, Estefania; Wang, Yuzhuo; Parolia, Abhijit; Cieslik, Marcin; Robinson, Dan R.; Wang, Zhen; Feng, Felix Y.; Chou, Jonathan; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.
NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis
NATURE GENETICS
IF31.8
2024-09-092
OAAI
Parolia, Abhijit; Eyunni, Sanjana; Verma, Brijesh Kumar; Young, Eleanor; Liu, Yihan; Liu, Lianchao; George, James; Aras, Shweta; Das, Chandan Kanta; Mannan, Rahul; Rasool, Reyaz Ur; Mitchell-Velasquez, Erick; Mahapatra, Somnath; Luo, Jie; Carson, Sandra E.; Xiao, Lanbo; Gajjala, Prathibha R.; Venkatesh, Sharan; Jaber, Mustapha; Wang, Xiaoju; He, Tongchen; Qiao, Yuanyuan; Pang, Matthew; Zhang, Yuping; Tien, Jean Ching-Yi; Louw, Micheala; Alhusayan, Mohammed; Cao, Xuhong; Su, Fengyun; Tavana, Omid; Hou, Caiyun; Wang, Zhen; Ding, Ke; Chinnaiyan, Arul M.; Asangani, Irfan A.
Targeting lipid metabolism in pancreatic cancer
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Cheng, Caleb; Wisniewski, Jasmine P.; Korkaya, Ahmet; Jackson, Bailey; Mannan, Rahul; Mahapatra, Somnath; Rossiter, Nicholas; Bhattacharyya, Rupam; Morlacchi, Pietro; Peters, Sydney; Qiao, Yuanyuan; Lyssiotis, Costas A.; Chinnaiyan, Arul M.
Monsoon Mission: A Targeted Activity to Improve Monsoon Prediction across Scales
BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
IF5.9
2019-12-0178
OAAI
Rao, Suryachandra A.; Goswami, B. N.; Sahai, Atul Kumar; Rajagopal, E. N.; Mukhopadhyay, P.; Rajeevan, M.; Nayak, Shailesh; Rathore, L. S.; Shenoi, S. S. C.; Ramesh, K. J.; Nanjundiah, R. S.; Ravichandran, M.; Mitra, A. K.; Pai, D. S.; Bhowmik, S. K. R.; Hazra, A.; Mahapatra, S.; Saha, S. K.; Chaudhari, H. S.; Joseph, S.; Pentakota, S.; Pokhrel, S.; Pillai, P. A.; Deshpande, M.; Phani, M. K.; Siddharth, R.; Prasad, V. S.; Abhilash, S.; Panickal, S.; Krishnan, R.; Kumar, S.; Dandi, R.; Reddy, S.; Arora, A.; Goswami, T.; Rai, A.; Srivastava, A.; Pradhan, M.; Tirkey, S.; Ganai, M.; Mandal, R.; Dey, A.; Sarkar, S.; Malviya, S.; Dhakate, A.; Salunke, K.; Maini, Parvinder

研究方向

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A
Arul M. Chinnaiyan
H 指数:144论文数:1,701被引数:9.7万
X
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H 指数:82论文数:528被引数:4.7万
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Suryachandra A. Rao
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A
Ashish Dhakate
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Y
Yuanyuan Qiao
H 指数:32论文数:242被引数:4,144
K
Kiran Salunke
H 指数:17论文数:43被引数:1,340
L
Licheng Zhou
H 指数:28论文数:188被引数:3,909
C
C. T. Sabeerali
H 指数:19论文数:39被引数:1,316
H
Hemantkumar S. Chaudhari
H 指数:29论文数:105被引数:2,697