Ryan, Tristram A. J.; Hooftman, Alexander; Rehill, Aisling M.; Johansen, Matt D.; O' Brien, Eoin C.; Toller-Kawahisa, Juliana E.; Wilk, Mieszko M.; Day, Emily A.; Weiss, Hauke J.; Sarvari, Pourya; Vozza, Emilio G.; Schramm, Fabian; Peace, Christian G.; Zotta, Alessia; Miemczyk, Stefan; Nalkurthi, Christina; Hansbro, Nicole G.; McManus, Gavin; O'Doherty, Laura; Gargan, Siobhan; Long, Aideen; Dunne, Jean; Cheallaigh, Cliona Ni; Conlon, Niall; Carty, Michael; Fallon, Padraic G.; Mills, Kingston H. G.; Creagh, Emma M.; O' Donnell, James S.; Hertzog, Paul J.; Hansbro, Philip M.; McLoughlin, Rachel M.; Wygrecka, Malgorzata; Preston, Roger J. S.; Zaslona, Zbigniew; O'Neill, Luke A. J.

The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils

NATURE COMMUNICATIONS

IF15.7

2023-07-1711

OAAI

Toller-Kawahisa, Juliana Escher; Hiroki, Carlos Hiroji; Silva, Camila Meirelles de Souza; Nascimento, Daniele Carvalho; Publio, Gabriel Azevedo; Martins, Timna Varela; Damasceno, Luis Eduardo Alves; Veras, Flavio Protasio; Viacava, Paula Ramos; Sukesada, Fabio Yuji; Day, Emily Anne; Zotta, Alessia; Ryan, Tristram Alexander Jasper; da Silva, Rodrigo Moreira; Cunha, Thiago Mattar; Lopes, Norberto Peporine; Cunha, Fernando de Queiroz; O'Neill, Luke Anthony John; Alves-Filho, Jose Carlos

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

富马酸二甲酯和衣康酸4-辛酯是通过抑制I型干扰素抑制巨噬细胞组织因子的抗凝剂

NATURE COMMUNICATIONS

IF15.7

2023-06-1421

OAAI

Ryan, Tristram A. J.; Hooftman, Alexander; Rehill, Aisling M.; Johansen, Matt D.; O'Brien, Eoin C.; Toller-Kawahisa, Juliana E.; Wilk, Mieszko M.; Day, Emily A.; Weiss, Hauke J.; Sarvari, Pourya; Vozza, Emilio G.; Schramm, Fabian; Peace, Christian G.; Zotta, Alessia; Miemczyk, Stefan; Nalkurthi, Christina; Hansbro, Nicole G.; McManus, Gavin; O'Doherty, Laura; Gargan, Siobhan; Long, Aideen; Dunne, Jean; Cheallaigh, Cliona Ni; Conlon, Niall; Carty, Michael; Fallon, Padraic G.; Mills, Kingston H. G.; Creagh, Emma M.; O'Donnell, James S.; Hertzog, Paul J.; Hansbro, Philip M.; McLoughlin, Rachel M.; Wygrecka, Malgorzata; Preston, Roger J. S.; Zaslona, Zbigniew; O'Neill, Luke A. J.

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

巨噬细胞延胡索酸水合酶抑制mtRNA介导的干扰素产生

Nature

IF48.5

2023-03-080

PRE

Alexander Hooftman; Christian G. Peace; Dylan G. Ryan; Emily A. Day; Ming Yang; Anne F. McGettrick; Maureen Yin; Erica N. Montano; Lihong Huo; Juliana E. Toller-Kawahisa; Vincent Zecchini; Tristram A. J. Ryan; Alfonso Bolado-Carrancio; Alva M. Casey; Hiran A. Prag; Ana S. H. Costa; Gabriela De Los Santos; Mariko Ishimori; Daniel J. Wallace; Swamy Venuturupalli; Efterpi Nikitopoulou; Norma Frizzell; Cecilia Johansson; Alexander Von Kriegsheim; Michael P. Murphy; Caroline Jefferies; Christian Frezza; Luke A. J. O’Neill

Protein targeting by the itaconate family in immunity and inflammation

BIOCHEMICAL JOURNAL

IF4.3

2022-12-2215

PRE

The phosphorylation of AMPKß1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Ampkß 1的磷酸化对于增加自噬和维持线粒体稳态以响应脂肪酸至关重要

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-11-2112

OAAI

Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site