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Alexander Hooftman

Trinity College Dublin
H指数:12
被引数:1,784

个人简介

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教育背景

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工作经历

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荣誉奖项

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4-Octyl itaconate blocks STAT3-induced ACE2 expression to reduce uptake of SARS-CoV-2

4-辛基衣康酸酯通过阻断STAT3诱导的ACE2表达来减少SARS-CoV-2的摄取

Biochemical Pharmacology
IF5.6
2026-04-250
OAAI
Hauke J. Weiss; Alexander Hooftman; Clarisse Salgado-Benvindo; Robbert Boudewijns; Laurens Liesenborghs; Tristram A.J. Ryan; Demi van der Horst; Madalina E. Carter-Timofte; Hossam Gewaid; Andrew Bowie; Hendrik Jan Thibaut; Kai Dallmeier; David Olagnier; Martijn J. van Hemert; Luke A.J. O’Neill
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon (vol 14, 3513, 2023)

富马酸二甲酯和衣康酸4-辛酯是通过抑制I型干扰素抑制巨噬细胞组织因子的抗凝剂 (第14卷，3513，2023)

NATURE COMMUNICATIONS
IF15.7
2023-07-200
OAAI
Ryan, Tristram A. J.; Hooftman, Alexander; Rehill, Aisling M.; Johansen, Matt D.; O' Brien, Eoin C.; Toller-Kawahisa, Juliana E.; Wilk, Mieszko M.; Day, Emily A.; Weiss, Hauke J.; Sarvari, Pourya; Vozza, Emilio G.; Schramm, Fabian; Peace, Christian G.; Zotta, Alessia; Miemczyk, Stefan; Nalkurthi, Christina; Hansbro, Nicole G.; McManus, Gavin; O'Doherty, Laura; Gargan, Siobhan; Long, Aideen; Dunne, Jean; Cheallaigh, Cliona Ni; Conlon, Niall; Carty, Michael; Fallon, Padraic G.; Mills, Kingston H. G.; Creagh, Emma M.; O' Donnell, James S.; Hertzog, Paul J.; Hansbro, Philip M.; McLoughlin, Rachel M.; Wygrecka, Malgorzata; Preston, Roger J. S.; Zaslona, Zbigniew; O'Neill, Luke A. J.
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

富马酸二甲酯和衣康酸4-辛酯是通过抑制I型干扰素抑制巨噬细胞组织因子的抗凝剂

NATURE COMMUNICATIONS
IF15.7
2023-06-1421
OAAI
Ryan, Tristram A. J.; Hooftman, Alexander; Rehill, Aisling M.; Johansen, Matt D.; O'Brien, Eoin C.; Toller-Kawahisa, Juliana E.; Wilk, Mieszko M.; Day, Emily A.; Weiss, Hauke J.; Sarvari, Pourya; Vozza, Emilio G.; Schramm, Fabian; Peace, Christian G.; Zotta, Alessia; Miemczyk, Stefan; Nalkurthi, Christina; Hansbro, Nicole G.; McManus, Gavin; O'Doherty, Laura; Gargan, Siobhan; Long, Aideen; Dunne, Jean; Cheallaigh, Cliona Ni; Conlon, Niall; Carty, Michael; Fallon, Padraic G.; Mills, Kingston H. G.; Creagh, Emma M.; O'Donnell, James S.; Hertzog, Paul J.; Hansbro, Philip M.; McLoughlin, Rachel M.; Wygrecka, Malgorzata; Preston, Roger J. S.; Zaslona, Zbigniew; O'Neill, Luke A. J.
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

巨噬细胞延胡索酸水合酶抑制mtRNA介导的干扰素产生

Nature
IF48.5
2023-03-080
PRE
Alexander Hooftman; Christian G. Peace; Dylan G. Ryan; Emily A. Day; Ming Yang; Anne F. McGettrick; Maureen Yin; Erica N. Montano; Lihong Huo; Juliana E. Toller-Kawahisa; Vincent Zecchini; Tristram A. J. Ryan; Alfonso Bolado-Carrancio; Alva M. Casey; Hiran A. Prag; Ana S. H. Costa; Gabriela De Los Santos; Mariko Ishimori; Daniel J. Wallace; Swamy Venuturupalli; Efterpi Nikitopoulou; Norma Frizzell; Cecilia Johansson; Alexander Von Kriegsheim; Michael P. Murphy; Caroline Jefferies; Christian Frezza; Luke A. J. O’Neill
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
CELL METABOLISM
IF30.9
2022-03-01156
OA
Runtsch, Marah C.; Angiari, Stefano; Hooftman, Alexander; Wadhwa, Ridhima; Zhang, Yanling; Zheng, Yunan; Spina, Joseph S.; Ruzek, Melanie C.; Argiriadi, Maria A.; McGettrick, Anne F.; Mendez, Rui Santalla; Zotta, Alessia; Peace, Christian G.; Walsh, Aoife; Chirillo, Roberta; Hams, Emily; Fallon, Padraic G.; Jayamaran, Ranjith; Dua, Kamal; Brown, Alexandra C.; Kim, Richard Y.; Horvat, Jay C.; Hansbro, Philip M.; Wang, Chu; O'Neill, Luke A. J.
Caspase-11 promotes allergic airway inflammation

Caspase-11促进过敏性气道炎症

NATURE COMMUNICATIONS
IF15.7
2020-02-2659
OAAI
Zaslona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M.; Carroll, Richard G.; Palsson-McDermott, Eva M.; Hughes, Mark M.; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G.; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J.; Mills, Kingston H. G.; Lavelle, Ed C.; Wygreck, Malgorzata; Creagh, Emma M.; O'Neill, Luke A. J.
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

谷胱甘肽转移酶Omega-1通过NEK7脱谷氨酰化调节NLRP3炎性体激活

CELL REPORTS
IF6.9
2019-10-0166
OAAI
Hughes, Mark M.; Hooftman, Alexander; Angiari, Stefano; Tummala, Padmaja; Zaslona, Zbigniew; Runtsch, Marah C.; McGettrick, Anne F.; Sutton, Caroline E.; Diskin, Ciana; Rooke, Melissa; Takahashi, Shuhei; Sundararaj, Srinivasan; Casarotto, Marco G.; Dahlstrom, Jane E.; Palsson-McDermott, Eva M.; Corr, Sinead C.; Mills, Kingston H. G.; Preston, Roger J. S.; Neamati, Nouri; Xie, Yiyue; Baell, Jonathan B.; Board, Philip G.; O'Neill, Luke A. J.

研究方向

暂未获取到该数据
L
Luke O'neill
H 指数:143论文数:710被引数:9.7万
C
Christian G. Peace
H 指数:7论文数:14被引数:738
E
Emily A. Day
H 指数:23论文数:50被引数:3,818
A
Anne F. McGettrick
H 指数:27论文数:40被引数:1.0万
A
Alessia Zotta
H 指数:11论文数:29被引数:713
K
Kingston H. G. Mills
H 指数:101论文数:458被引数:4.4万
Z
Zbigniew Zasłona
H 指数:29论文数:143被引数:4,837
P
Padraic G. Fallon
H 指数:84论文数:350被引数:2.8万
P
Philip M. Hansbro
H 指数:89论文数:790被引数:3.1万
S
Stefano Angiari
H 指数:24论文数:58被引数:4,809