未登录Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential
Khoumeri, Omar; Hutter, Sebastien; Primas, Nicolas; Castera-Ducros, Caroline; Carvalho, Sandra; Wyllie, Susan; Efrit, Mohamed Lotfi; Fayolle, Dimitri; Since, Marc; Vanelle, Patrice; Verhaeghe, Pierre; Azas, Nadine; El-Kashef, Hussein .png)
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收藏Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stabilityLagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Casanova, Marion; Franetich, Jean-Francois; Tajeri, Shahin; Malzert-Freon, Aurelie; Corvaisier, Sophie; Since, Marc; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent 分享 收藏 New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stabilityLagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Casanova, Marion; Franetich, Jean-Francois; Tajeri, Shahin; Malzert-Freon, Aurelie; Corvaisier, Sophie; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent 分享 收藏 Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategyMustiere, Romain; Lagardere, Prisca; Hutter, Sebastien; Dell'Orco, Viviana; Amanzougaghene, Nadia; Tajeri, Shahin; Franetich, Jean-Francois; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Masurier, Nicolas; Lisowski, Vincent; Verhaeghe, Pierre; Mazier, Dominique; Azas, Nadine; Vanelle, Patrice; Primas, Nicolas 分享 收藏 分享 收藏 Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial PharmacophorePaoli-Lombardo, Romain; Primas, Nicolas; Bourgeade-Delmas, Sandra; Hutter, Sebastien; Sournia-Saquet, Alix; Boudot, Clotilde; Brenot, Emilie; Castera-Ducros, Caroline; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Courtioux, Bertrand; Valentin, Alexis; Verhaeghe, Pierre; Azas, Nadine; Rathelot, Pascal; Vanelle, Patrice 分享 收藏 4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial DerivativesLagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Franetich, Jean-Francois; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent 分享 收藏 Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparumAmrane, Dyhia; Primas, Nicolas; Arnold, Christophe-Sebastien; Hutter, Sebastien; Louis, Beatrice; Sanz-Serrano, Julen; Azqueta, Amaya; Amanzougaghene, Nadia; Tajeri, Shahin; Mazier, Dominique; Verhaeghe, Pierre; Azas, Nadine; Botte, Cyrille; Vanelle, Patrice 分享 收藏 A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant ParasitesBosson-Vanga, Henriette; Primas, Nicolas; Franetich, Jean-Francois; Lavazec, Catherine; Gomez, Lina; Ashraf, Kutub; Tefit, Maurel; Soulard, Valerie; Dereuddre-Bosquet, Nathalie; Le Grand, Roger; Donnette, Melanie; Mustiere, Romain; Amanzougaghene, Nadia; Tajeri, Shahin; Suzanne, Peggy; Malzert-Freon, Aurelie; Rault, Sylvain; Vanelle, Patrice; Hutter, Sebastien; Cohen, Anita; Snounou, Georges; Roques, Pierre; Azas, Nadine; Lagardere, Prisca; Lisowski, Vincent; Masurier, Nicolas; Nguyen, Michel; Paloque, Lucie; Benoit-Vical, Francoise; Verhaeghe, Pierre; Mazier, Dominique 分享 收藏 分享 收藏 2-Phenoxy-3-Trichloromethylquinoxalines Are Antiplasmodial Derivatives with Activity against the Apicoplast of Plasmodium falciparum2-苯氧基-3-三氯甲基喹喔啉是抗疟原虫衍生物，具有抗恶性疟原虫的Apicoplast活性Amrane, Dyhia; Arnold, Christophe-Sebastien; Hutter, Sebastien; Sanz-Serrano, Julen; Collia, Miguel; Azqueta, Amaya; Paloque, Lucie; Cohen, Anita; Amanzougaghene, Nadia; Tajeri, Shahin; Franetich, Jean-Francois; Mazier, Dominique; Benoit-Vical, Francoise; Verhaeghe, Pierre; Azas, Nadine; Vanelle, Patrice; Botte, Cyrille; Primas, Nicolas 分享 收藏 Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive BackbonesSalas-Ambrosio, Pedro; Tronnet, Antoine; Since, Marc; Bourgeade-Delmas, Sandra; Stigliani, Jean-Luc; Vax, Amelie; Lecommandoux, Sebastien; Dupuy, Bruno; Verhaeghe, Pierre; Bonduelle, Colin 分享 收藏 Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T.b. brucei hitcompound with improved pharmacokinetic propertiesFersing, Cyril; Boudot, Clotilde; Paoli-Lombardo, Romain; Primas, Nicolas; Pinault, Emilie; Hutter, Sebastien; Castera-Ducros, Caroline; Kabri, Youssef; Pedron, Julien; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Valentin, Alexis; Azqueta, Amaya; Muruzabal, Damian; Destere, Alexandre; Wyllie, Susan; Fairlamb, Alan H.; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Di Giorgio, Carole; Rathelot, Pascal; Azas, Nadine; Courtioux, Bertrand; Vanelle, Patrice; Verhaeghe, Pierre 分享 收藏 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruziFersing, Cyril; Boudot, Clotilde; Castera-Ducros, Caroline; Pinault, Emilie; Hutter, Sebastien; Paoli-Lombardo, Romain; Primas, Nicolas; Pedron, Julien; Seguy, Line; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Brossas, Jean-Yves; Paris, Luc; Valentin, Alexis; Wyllie, Susan; Fairlamb, Alan H.; Boutet-Robinet, Elisa; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Destere, Alexandre; Mazier, Dominique; Rathelot, Pascal; Courtioux, Bertrand; Azas, Nadine; Verhaeghe, Pierre; Vanelle, Patrice 分享 收藏 分享 收藏 分享 收藏 New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruziPedron, Julien; Boudot, Clotilde; Brossas, Jean-Yves; Pinault, Emilie; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Boutet-Robinet, Elisa; Destere, Alexandre; Tronnet, Antoine; Berge, Justine; Bonduelle, Colin; Deraeve, Celine; Pratviel, Genevieve; Stigliani, Jean-Luc; Paris, Luc; Mazier, Dominique; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aureprimelie; Wyllie, Susan; Milne, Rachel; Fairlamb, Alan H.; Valentin, Alexis; Courtioux, Bertrand; Verhaeghe, Pierre 分享 收藏 Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial ActivityFersing, Cyril; Basmaciyan, Louise; Boudot, Clotilde; Pedron, Julien; Hatter, Sebastien; Cohen, Anita; Castera-Ducros, Caroline; Primas, Nicolas; Laget, Michele; Casanova, Magali; Bourgeade-Delmas, Sandra; Piednoel, Melanie; Sournia-Saquet, Alix; Mbou, Valere Belle; Courtioux, Bertrand; Boutet-Robinet, Elisa; Since, Marc; Milne, Rachel; Wyllie, Susan; Fairlamb, Alan H.; Valentin, Alexis; Rathelot, Pascal; Verhaeghe, Pierre; Vanelle, Patrice; Azas, Nadine 分享 收藏 分享 收藏 Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling ReactionsPedron, Julien; Boudot, Clotilde; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Paloque, Lucie; Rastegari, Maryam; Abdoulaye, Mansour; El-Kashef, Hussein; Bonduelle, Colin; Pratviel, Genevieve; Wyllie, Susan; Fairlamb, Alan H.; Courtioux, Bertrand; Verhaeghe, Pierre; Valentin, Alexis 分享 收藏 
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