J. P. Johnson

Vertex Pharmaceuticals

H指数:33

被引数:4,235

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The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2024-06-240

Johnson, James P.; Focken, Thilo; Karimi Tari, Parisa; Dube, Celine; Goodchild, Samuel J.; Andrez, Jean-Christophe; Bankar, Girish; Burford, Kristen; Chang, Elaine; Chowdhury, Sultan; Christabel, Jessica; Dean, Richard; de Boer, Gina; Dehnhardt, Christoph; Gong, Wei; Grimwood, Michael; Hussainkhel, Angela; Jia, Qi; Khakh, Kuldip; Lee, Stephanie; Li, Jenny; Lin, Sophia; Lindgren, Andrea; Lofstrand, Verner; Mezeyova, Janette; Nelkenbrecher, Karen; Shuart, Noah Gregory; Sojo, Luis; Sun, Shaoyi; Waldbrook, Matthew; Wesolowski, Steven; Wilson, Michael; Xie, Zhiwei; Zenova, Alla; Zhang, Wei; Scott, Fiona L.; Cutts, Alison J.; Sherrington, Robin P.; Winquist, Raymond; Cohen, Charles J.; Empfield, James R.

Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo

ACS CHEMICAL NEUROSCIENCE

IF3.9

2024-02-156

OAAI

Structure-function relationship of new peptides activating human Nav1.1

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2023-09-013

OAAI

Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-Cell death-associated gene 8 receptor

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-2772

OAAI

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-03-0822

PREAI

Safina, Brian S.; McKerrall, Steven J.; Sun, Shaoyi; Chen, Chien-An; Chowdhury, Sultan; Jia, Qi; Li, Jun; Zenova, Alla Y.; Andrez, Jean-Christophe; Bankar, Girish; Bergeron, Philippe; Chang, Jae H.; Chang, Elaine; Chen, Jun; Dean, Richard; Decker, Shannon M.; DiPasquale, Antonio; Focken, Thilo; Hemeon, Ivan; Khakh, Kuldip; Kim, Amy; Kwan, Rainbow; Lindgren, Andrea; Lin, Sophia; Maher, Jonathan; Mezeyova, Janette; Misner, Dinah; Nelkenbrecher, Karen; Pang, Jodie; Reese, Rebecca; Shields, Shannon D.; Sojo, Luis; Sheng, Tao; Verschoof, Henry; Waldbrook, Matthew; Wilson, Michael S.; Xie, Zhiwei; Young, Clint; Zabka, Tanja S.; Hackos, David H.; Ortwine, Daniel F.; White, Andrew D.; Johnson, J. P., Jr.; Robinette, C. Lee; Dehnhardt, Christoph M.; Cohen, Charles J.; Sutherlin, Daniel P.

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-09-1720

PREAI

Focken, Thilo; Burford, Kristen; Grimwood, Michael E.; Zenova, Alla; Andrez, Jean-Christophe; Gong, Wei; Wilson, Michael; Taron, Matt; Decker, Shannon; Lofstrand, Verner; Chowdhury, Sultan; Shuart, Noah; Lin, Sophia; Goodchild, Samuel J.; Young, Clint; Soriano, Maegan; Tari, Parisa K.; Waldbrook, Matthew; Nelkenbrecher, Karen; Kwan, Rainbow; Lindgren, Andrea; de Boer, Gina; Lee, Stephanie; Sojo, Luis; DeVita, Robert J.; Cohen, Charles J.; Wesolowski, Steven S.; Johnson, J. P., Jr.; Dehnhardt, Christoph M.; Empfield, James R.

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-04-0325

PREAI

McKerrall, Steven J.; Nguyen, Teresa; Lai, Kwong Wah; Bergeron, Philippe; Deng, Lunbin; DiPasquale, Antonio; Chang, Jae H.; Chen, Jun; Chernov-Rogan, Tania; Hackos, David H.; Maher, Jonathan; Ortwine, Daniel F.; Pang, Jodie; Payandeh, Jian; Proctor, William R.; Shields, Shannon D.; Vogt, Jennifer; Ji, Pengfei; Liu, Wenfeng; Ballini, Elisa; Schumann, Lilia; Tarozzo, Glauco; Bankar, Girish; Chowdhury, Sultan; Hasan, Abid; Johnson, J. P., Jr.; Khakh, Kuldip; Lin, Sophia; Cohen, Charles J.; Dehnhardt, Christoph M.; Safina, Brian S.; Sutherlin, Daniel P.

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Nav) 1.7 with Potent Analgesic Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-11-3028

PREAI

Sun, Shaoyi; Jia, Qj; Zenova, Alla Y.; Wilson, Michael S.; Chowdhury, Sultan; Focken, Thilo; Li, Jun; Decker, Shannon; Grimwood, Michael E.; Andrez, Jean-Christophe; Hemeon, Ivan; Sheng, Tao; Chen, Chien-An; White, Andy; Hackos, David H.; Deng, Lunbin; Bankar, Girish; Khakh, Kuldip; Chang, Elaine; Kwan, Rainbow; Lin, Sophia; Nelkenbrecher, Karen; Sellers, Benjamin D.; DiPasquale, Antonio G.; Chang, Jae; Pang, Jodie; Sojo, Luis; Lindgren, Andrea; Waldbrook, Matthew; Xie, Zhiwei; Young, Clint; Johnson, James P.; Robinette, C. Lee; Cohen, Charles J.; Safina, Brian S.; Sutherlin, Daniel P.; Ortwine, Daniel F.; Dehnhardt, Christoph M.

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain

CELL REPORTS

IF6.9

2018-09-0151

OAAI

Experimental investigation of hardwood air gasification in a pilot scale bubbling fluidized bed reactor and CFD simulation of jet/grid and pressure conditions

ENERGY CONVERSION AND MANAGEMENT

IF10.9

2018-07-0127

OAAI

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)methane-sulfonamidesas Potent and Selective hNav1.7 Inhibitors for the Treatment of Pain

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-05-0827

PREAI

Focken, Thilo; Chowdhury, Sultan; Zenova, Alla; Grimwood, Michael E.; Chabot, Christine; Sheng, Tao; Hemeon, Ivan; Decker, Shannon M.; Wilson, Michael; Bichler, Paul; Jia, Qi; Sun, Shaoyi; Young, Clint; Lin, Sophia; Goodchild, Samuel J.; Shuart, Noah G.; Chang, Elaine; Xie, Zhiwei; Li, Bowen; Khakh, Kuldip; Bankar, Girish; Waldbrook, Matthew; Kwan, Rainbow; Nelkenbrecher, Karen; Tari, Parisa Karimi; Chahal, Navjot; Sojo, Luis; Robinette, C. Lee; White, Andrew D.; Chen, Chien-An; Zhang, Yi; Pang, Jodie; Chang, Jae H.; Hackos, David H.; Johnson, J. P.; Cohen, Charles J.; Ortwine, Daniel F.; Sutherlin, Daniel P.; Dehnhardt, Christoph M.; Safina, Brian S.

Structural Basis of Nav1.7 Inhibition by an Isoform-Selective Small Molecule Antagonist

BIOPHYSICAL JOURNAL

IF3.1

2016-02-012

OAAI

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models

发现芳基磺胺类药物作为NaV1.7的同工型选择性抑制剂，在啮齿动物疼痛模型中有效

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2016-01-1977

OAAI

Ivacaftor potentiation of multiple CFTR channels with gating mutations