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Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity 具有体内活性的支链 α-酮酸脱氢酶激酶 (BDK) 的双环抑制剂 Liang, Jue; Wang, Xiaoyu; Ortiz, Francisco; Shishodia, Gauri; Liu, Tian; Gao, Chen; Williams, Noelle S.; Chuang, David T.; Wynn, R. Max; Ready, Joseph M. 分享 收藏
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency Tesla, Rachel; Guhl, Charlotte; Werthmann, Gordon C.; Dixon, Danielle; Cenik, Basar; Addepalli, Yesu; Liang, Jue; Fass, Daniel M.; Rosenthal, Zachary; Haggarty, Stephen J.; Williams, Noelle S.; Posner, Bruce A.; Ready, Joseph M.; Herz, Joachim 分享 收藏
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers 烟酰胺的噻吩衍生物通过NAD救助途径代谢为抑制IMPDH并对周围神经癌有毒的非天然NAD衍生物 Theodoropoulos, Panayotis C.; Guo, Holly H.; Wang, Wentian; Crossley, Eric; Cancel, Giomar Rivera; Fang, Min; Nguyen, Thu; Baniasadi, Hamid; Williams, Noelle S.; Ready, Joseph M.; De Brabander, Jef K.; Nijhawan, Deepak 分享 收藏
Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells Wang, Hua-Yu; Nguyen, Thu P.; Sternisha, Alex C.; Carroll, Christopher L.; Cross, Bethany; Morlock, Lorraine; Williams, Noelle S.; Mcbrayer, Samuel; Nijhawan, Deepak; De Brabander, Jef K. 分享 收藏
Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis 色氨酸通过吲哚3-丙酮酸合成促进MYC依赖性肝肿瘤发生 Venkateswaran, Niranjan; Garcia, Roy; Lafita-Navarro, M. Carmen; Hao, Yi-Heng; Perez-Castro, Lizbeth; Nogueira, Pedro A. S.; Solmonson, Ashley; Mender, Ilgen; Kilgore, Jessica A.; Fang, Shun; Brown, Isabella N.; Li, Li; Parks, Emily; dos Santos, Igor Lopes; Bhaskar, Mahima; Kim, Jiwoong; Jia, Yuemeng; Lemoff, Andrew; Grishin, Nick V.; Kinch, Lisa; Xu, Lin; Williams, Noelle S.; Shay, Jerry W.; Deberardinis, Ralph J.; Zhu, Hao; Conacci-Sorrell, Maralice 分享 收藏
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia Rosenthal, Zachary C.; Fass, Daniel M.; Payne, N. Connor; She, Angela; Patnaik, Debasis; Hennig, Krista M.; Tesla, Rachel; Werthmann, Gordon C.; Guhl, Charlotte; Reis, Surya A.; Wang, Xiaoyu; Chen, Yueting; Placzek, Michael; Williams, Noelle S.; Hooker, Jacob; Herz, Joachim; Mazitschek, Ralph; Haggarty, Stephen J. 分享 收藏
Targeting of neuroblastoma cells through Kynurenine-AHR pathway inhibition 通过抑制犬尿氨酸-AHR通路靶向神经母细胞瘤细胞 dos Santos, Igor Lopes; Mitchell, Michael; Nogueira, Pedro A. S.; Lafita-Navarro, M. Carmen; Perez-Castro, Lizbeth; Eriom, Joyane; Kilgore, Jessica A.; Williams, Noelle S.; Guo, Lei; Xu, Lin; Conacci-Sorrell, Maralice 分享 收藏
Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway Tripathi, Amit K.; Desai, Priyanka P.; Tyagi, Antariksh; Lampe, Jana B.; Srivastava, Yogesh; Donkor, Michael; Jones, Harlan P.; Dzyuba, Sergei, V; Crossley, Eric; Williams, Noelle S.; Vishwanatha, Jamboor K. 分享 收藏
Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis Prakasam, Gopinath; Mishra, Akhilesh; Christie, Alana; Miyata, Jeffrey; Carrillo, Deyssy; Tcheuyap, Vanina T.; Ye, Hui; Do, Quyen N.; Wang, Yunguan; Torras, Oscar Reig; Butti, Ramesh; Zhong, Hua; Gagan, Jeffrey; Jones, Kevin B.; Carroll, Thomas J.; Modrusan, Zora; Durinck, Steffen; Requena-Komuro, Mai -Carmen; Williams, Noelle S.; Pedrosa, Ivan; Wang, Tao; Rakheja, Dinesh; Kapur, Payal; Brugarolas, James 分享 收藏
Orthogonal Hydroxyl Functionalization of cGAMP Confers Metabolic Stability and Enables Antibody Conjugation Lu, Yong; You, Lin; Li, Liping; Kilgore, Jessica A.; Liu, Shun; Wang, Xiaoyu; Dai, Yuanwei; Wei, Qi; Shi, Heping; Han, Lei; Sun, Lijun; Chen, Zhijian J.; Zhang, Xuewu; Williams, Noelle S.; Chen, Chuo 分享 收藏
FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms Ahmed, Mahmoud S.; Farag, Ayman B.; Boys, Ian N.; Wang, Ping; Menendez-Montes, Ivan; Nguyen, Ngoc Uyen Nhi; Eitson, Jennifer L.; Ohlson, Maikke B.; Fan, Wenchun; McDougal, Matthew B.; Mar, Katrina; Thet, Suwannee; Ortiz, Francisco; Kim, Soo Young; Solmonson, Ashley; Williams, Noelle S.; Lemoff, Andrew; DeBerardinis, Ralph J.; Schoggins, John W.; Sadek, Hesham A. 分享 收藏
Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hurthle Cell Carcinoma of the Thyroid Frank, Anderson R.; Li, Vicky; Shelton, Spencer D.; Kim, Jiwoong; Stott, Gordon M.; Neckers, Leonard M.; Xie, Yang; Williams, Noelle S.; Mishra, Prashant; McFadden, David G. 分享 收藏
Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice Sun, Yu; Ranjan, Alok; Tisdale, Ryan; Ma, Shun-Chieh; Park, Sunmee; Haire, Meghan; Heu, Jasmine; Morairty, Stephen R.; Wang, Xiaoyu; Rosenbaum, Daniel M. M.; Williams, Noelle S. S.; De Brabander, Jef K. K.; Kilduff, Thomas S. S. 分享 收藏
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