John M. Pascal - Publications, H-index & Citations

John M. Pascal

université de montréal

49H指数

168论文数

8.7K被引数

收录论文 72

发表时间

PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly PARP4通过ADP核糖基化PIDD1，完成一个调控PIDD体组装的磷酸化/SUMO化/PAR化级联反应

Science Advances

IF12.5

2026-04-29

OAAI

Richa B. Shah; Yuanyuan Li; Ashley Person; Léonie Frigon; Nina Ðukić; Ela Kini; Raymond Chen; John M. Pascal; Michael S. Cohen; Ivan Ahel; John D. Haley; Samuel Sidi

PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation PARP1-HPF1结构与动态在缺口DNA上的表现提示了一种急性且局部的ADP核糖基化机制

Nature Communications

IF15.7

2026-02-16

OAAI

Aleksandr Sverzhinsky; Huijun Xue; Marie-France Langelier; Marcelo V. Muniz Corrêa; Joshua Del Mundo; Scott Classen; Michal Hammel; Eli Rothenberg; John M. Pascal

PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex PARP1和PARylation通过稳定CSB-RNAPII复合物来促进转录偶联的DNA修复。

NUCLEIC ACIDS RESEARCH

IF13.1

2025-12-11

OAAI

Robu, Mihaela; Shah, Rashmi G.; Van den heuvel, Diana; Coulombe, Yan; Bazin, Marc; Van der woude, Melanie; Kragten, Angela; Lans, Hannes; Pascal, John M.; Masson, Jean-Yves; Luijsterburg, Martijn S.; Shah, Girish M.

PARP enzyme synthesis of protein-free poly(ADP-ribose): implications for DNA damage signaling and repair PARP酶合成无蛋白的聚(ADP-核糖)：对DNA损伤信号传导和修复的影响

DNA Repair

IF2.7

2025-09-27

PREAI

Marie-France Langelier; John M. Pascal

Inner membrane components of the plasmid pKM101 type IV secretion system TraE and TraD are DNA-binding proteins

SCIENTIFIC REPORTS

IF3.9

2025-03-04

OAAI

Jemouai, Zakaria; Sverzhinsky, Aleksandr; Sygusch, Jurgen; Pascal, John; Baron, Christian

A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation PARP2活性位点螺旋解旋以允许DNA损伤诱导的酶促激活

MOLECULAR CELL

IF16.6

2025-01-01

PREAI

Smith-Pillet, Emily S.; Billur, Ramya; Langelier, Marie-France; Talele, Tanaji T.; Pascal, John M.; Black, Ben E.

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

NATURE COMMUNICATIONS

IF15.7

2024-12-06

OAAI

Valerie, Nicholas C. K.; Sanjiv, Kumar; Mortusewicz, Oliver; Zhang, Si Min; Alam, Seher; Pires, Maria J.; Stigsdotter, Hannah; Rasti, Azita; Langelier, Marie-France; Rehling, Daniel; Throup, Adam; Purewal-Sidhu, Oryn; Desroses, Matthieu; Onireti, Jacob; Wakchaure, Prasad; Almloef, Ingrid; Bostrom, Johan; Bevc, Luka; Benzi, Giorgia; Stenmark, Pal; Pascal, John M.; Helleday, Thomas; Page, Brent D. G.; Altun, Mikael

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose)PARP酶从头合成无蛋白聚(ADP-核糖)

MOLECULAR CELL

IF16.6

2024-12-01

PREAI

Langelier, Marie-France; Mirhasan, Manija; Gilbert, Karine; Sverzhinksy, Aleksandr; Furtos, Alexandra; Pascal, John M.

Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks

BIOCHEMICAL JOURNAL

IF4.3

2024-03-13

OAAI

Velagapudi, Uday Kiran; Rouleau-Turcotte, Elise; Billur, Ramya; Shao, Xuwei; Patil, Manisha; Black, Ben E.; Pascal, John M.; Talele, Tanaji T.

ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-12-01

OAAI

Rouleau-Turcotte, Elise; Pascal, John M.

Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP

NUCLEIC ACIDS RESEARCH

IF13.1

2023-11-16

OAAI

Frigon, Leonie; Pascal, John M.

PARP-nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2023-08-01

OAAI

Pascal, John M.

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

SCIENCE ADVANCES

IF12.5

2023-03-24

OAAI

Langelier, Marie-France; Lin, Xiaohui; Zha, Shan; Pascal, John M.

PARP1 associates with R-loops to promote their resolution and genome stability

NUCLEIC ACIDS RESEARCH

IF13.1

2023-02-16

OAAI

Laspata, Natalie; Kaur, Parminder; Mersaoui, Sofiane Yacine; Muoio, Daniela; Liu, Zhiyan Silvia; Bannister, Maxwell Henry; Nguyen, Hai Dang; Curry, Caroline; Pascal, John M.; Poirier, Guy G.; Wang, Hong; Masson, Jean-Yves; Fouquerel, Elise

Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors

CELL CHEMICAL BIOLOGY

IF7.2

2022-12-01

OAAI

Arnold, Moriah R.; Langelier, Marie-France; Gartrell, Jessica; Kirby, Ilsa T.; Sanderson, Daniel J.; Bejan, Daniel S.; Sileikyte, Justina; Sundalam, Sunil K.; Nagarajan, Shanthi; Marimuthu, Parthiban; Duell, Anna K.; Shelat, Anang A.; Pascal, John M.; Cohen, Michael S.

Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose)

CELL REPORTS

IF6.9

2022-10-01

OAAI

Kuttiyatveetil, Jijin R. A.; Soufari, Heddy; Dasovich, Morgan; Uribe, Isabel R.; Mirhasan, Manija; Cheng, Shang-Jung; Leung, Anthony K. L.; Pascal, John M.

A two-step mechanism governing PARP1-DNA retention by PARP inhibitors

SCIENCE ADVANCES

IF12.5

2022-09-09

OAAI

Xue, Huijun; Bhardwaj, Amit; Yin, Yandong; Fijen, Carel; Ephstein, Anastasiya; Zhang, Lianglin; Ding, Xia; Pascal, John M.; VanArsdale, Todd L.; Rothenberg, Eli

Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery

MOLECULAR CELL

IF16.6

2022-08-01

OAAI

Rouleau-Turcotte, Elise; Krastev, Dragomir B.; Pettitt, Stephen J.; Lord, Christopher J.; Pascal, John M.

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

NATURE COMMUNICATIONS

IF15.7

2021-11-18

OAAI

Langelier, Marie-France; Billur, Ramya; Sverzhinsky, Aleksandr; Black, Ben E.; Pascal, John M.

ADP-ribosyltransferases, an update on function and nomenclature ADP-核糖基转移酶，功能和命名的更新

FEBS JOURNAL

IF4.2

2021-09-13

188

OAAI

Luscher, Bernhard; Ahel, Ivan; Altmeyer, Matthias; Ashworth, Alan; Bai, Peter; Chang, Paul; Cohen, Michael; Corda, Daniela; Dantzer, Francoise; Daugherty, Matthew D.; Dawson, Ted M.; Dawson, Valina L.; Deindl, Sebastian; Fehr, Anthony R.; Feijs, Karla L. H.; Filippov, Dmitri V.; Gagne, Jean-Philippe; Grimaldi, Giovanna; Guettler, Sebastian; Hoch, Nicolas C.; Hottiger, Michael O.; Korn, Patricia; Kraus, W. Lee; Ladurner, Andreas; Lehtio, Lari; Leung, Anthony K. L.; Lord, Christopher J.; Mangerich, Aswin; Matic, Ivan; Matthews, Jason; Moldovan, George-Lucian; Moss, Joel; Natoli, Gioacchino; Nielsen, Michael L.; Niepel, Mario; Nolte, Friedrich; Pascal, John; Paschal, Bryce M.; Pawlowski, Krzysztof; Poirier, Guy G.; Smith, Susan; Timinszky, Gyula; Wang, Zhao-Qi; Yelamos, Jose; Yu, Xiaochun; Zaja, Roko; Ziegler, Mathias

研究方向