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G

Guillaume M. Hautbergue

University of Sheffield
H指数:34
被引数:5,851

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Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis

腺苷脱氨酶介导的嘌呤功能障碍导致散发性肌萎缩侧索硬化症中的DNA修复抑制和衰老

International Journal of Molecular Sciences
IF4.9
2026-09-170
OA
Benjamin Hall; Yasmina M. Ebrahim; Joanne L. Sharpe; Sangeet Makhija; Brittany C. S. Ellis; Kari E. Wong; Heather Walker; Miriam Yagüe-Capilla; Hannah O. Timmons; Arian Bradley; Ella Nightingale; Rees Ross; Chloe F. Allen; Noemi Gatto; Herbie Garland; Nikita Soni; Stephen J. Kolb; J. Robin Highley; Guillaume M. Hautbergue; Sean G. Rudd; Ryan J. H. West; Pamela J. Shaw; Scott P. Allen
Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA

反义二肽重复蛋白通过ADA在C9orf72肌萎缩侧索硬化症中驱动广泛的嘌呤代谢异常

International Journal of Molecular Sciences
IF4.9
2026-02-260
OAAI
Benjamin Hall; Lydia Castelli; Adrian Higginbottom; Jingxuan He; Ling-Nan Zou; Heather Walker; Miriam Yagüe-Capilla; Kari E. Wong; David J. Burrows; Jonathan George; Keaton Hamer; Jenny M. Tanner; Ergita Kyrgiou-Balli; Rees Ross; Herbie Garland; Erin Tonkiss; Rachel George; Christopher P. Webster; Emma F. Smith; Hannah O. Timmons; Jess Allsop; Nikolas Stefanidis; Billie D. Ward; Ya-Hui Lin; J. Robin Highley; Mimoun Azzouz; Ryan J. H. West; Sean G. Rudd; Kurt J. De Vos; Pamela J. Shaw; Guillaume M. Hautbergue; Scott P. Allen
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations

Y374X TDP43截短导致由丙酮酸和TCA循环中间改变驱动的肌萎缩侧索硬化成纤维细胞的代谢谱改变

FRONTIERS IN AGING NEUROSCIENCE
IF4.5
2023-05-111
OAAI
Allen, Scott P. P.; Al Sultan, Afnan; Kibirige, Elaine Kabucho; Tonkiss, Erin; Hamer, Keaton J. J.; Castelli, Lydia M. M.; Lin, Ya-Hui; Roscoe, Sarah; Stefanidis, Nikolaos; Mead, Richard J. J.; Highley, J. Robin; Cooper-Knock, Johnathan; Hautbergue, Guillaume M. M.; Heath, Paul R. R.; Kirby, Janine; Shaw, Pamela J. J.
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins

阻断C9ORF72-repeat RNA核输出的细胞渗透肽可降低二肽重复蛋白的神经毒性作用

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-03-016
OA
Castelli, Lydia M.; Lin, Ya-Hui; Sanchez-Martinez, Alvaro; Gul, Aytac; Imran, Kamallia Mohd; Higginbottom, Adrian; Upadhyay, Santosh Kumar; Markus, Nora M.; Martins, Raquel Rua; Cooper-Knock, Johnathan; Montmasson, Claire; Cohen, Rebecca; Walton, Amy; Bauer, Claudia S.; De Vos, Kurt J.; Mead, Richard J.; Azzouz, Mimoun; Dominguez, Cyril; Ferraiuolo, Laura; Shaw, Pamela J.; Whitworth, Alexander J.; Hautbergue, Guillaume M.
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation

TMEM106B的丢失通过破坏自噬体成熟来加剧C9ALS/FTD DPR病理

FRONTIERS IN CELLULAR NEUROSCIENCE
IF4
2022-12-166
OAAI
Bauer, Claudia S.; Webster, Christopher P.; Shaw, Allan C.; Kok, Jannigje R.; Castelli, Lydia M.; Lin, Ya-Hui; Smith, Emma F.; Illanes-Alvarez, Francisco; Higginbottom, Adrian; Shaw, Pamela J.; Azzouz, Mimoun; Ferraiuolo, Laura; Hautbergue, Guillaume M.; Grierson, Andrew J.; De Vos, Kurt J.
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

EXOSC2的低表达可防止临床新型冠状病毒肺炎并阻止SARS-CoV-2复制

LIFE SCIENCE ALLIANCE
IF2.9
2022-10-141
OAAI
Moll, Tobias; Odon, Valerie; Harvey, Calum; Collins, Mark O.; Peden, Andrew; Franklin, John; Graves, Emily; Marshall, Jack N. G.; Souza, Cleide dos Santos; Zhang, Sai; Castelli, Lydia; Hautbergue, Guillaume; Azzouz, Mimoun; Gordon, David; Krogan, Nevan; Ferraiuolo, Laura; Snyder, Michael P.; Shaw, Pamela J.; Rehwinkel, Jan; Cooper-Knock, Johnathan
Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP

在TARDBP中携带p.Y374X截短突变的ALS系谱中的非典型TDP-43蛋白表达

BRAIN PATHOLOGY
IF6.2
2022-07-246
OAAI
Cooper-Knock, Johnathan; Julian, Thomas H.; Feneberg, Emily; Highley, J. Robin; Sidra, Maurice; Turner, Martin R.; Talbot, Kevin; Ansorge, Olaf; Allen, Scott P.; Moll, Tobias; Shelkovnikova, Tatyana; Castelli, Lydia; Hautbergue, Guillaume M.; Hewitt, Christopher; Kirby, Janine; Wharton, Stephen B.; Mead, Richard J.; Shaw, Pamela J.
C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
LIFE SCIENCE ALLIANCE
IF2.9
2022-05-137
OAAI
Marchi, Paolo M.; Marrone, Lara; Brasseur, Laurent; Coens, Audrey; Webster, Christopher P.; Bousset, Luc; Destro, Marco; Smith, Emma F.; Walther, Christa G.; Alfred, Victor; Marroccella, Raffaele; Graves, Emily J.; Robinson, Darren; Shaw, Allan C.; Wan, Lai Mei; Grierson, Andrew J.; Ebbens, Stephen J.; De Vos, Kurt J.; Hautbergue, Guillaume M.; Ferraiuolo, Laura; Melki, Ronald; Azzouz, Mimoun
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
MOLECULAR NEURODEGENERATION
IF17.5
2021-08-1014
OAAI
Castelli, Lydia M.; Cutillo, Luisa; Souza, Cleide Dos Santos; Sanchez-Martinez, Alvaro; Granata, Ilaria; Lin, Ya-Hui; Myszczynska, Monika A.; Heath, Paul R.; Livesey, Matthew R.; Ning, Ke; Azzouz, Mimoun; Shaw, Pamela J.; Guarracino, Mario R.; Whitworth, Alexander J.; Ferraiuolo, Laura; Milo, Marta; Hautbergue, Guillaume M.
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

直接转化的星形胶质细胞保留了供体成纤维细胞的衰老特征，并阐明了星形胶质细胞对人类中枢神经系统健康和疾病的贡献

AGING CELL
IF7.1
2020-12-1337
OAAI
Gatto, Noemi; Dos Santos Souza, Cleide; Shaw, Allan C.; Bell, Simon M.; Myszczynska, Monika A.; Powers, Samantha; Meyer, Kathrin; Castelli, Lydia M.; Karyka, Evangelia; Mortiboys, Heather; Azzouz, Mimoun; Hautbergue, Guillaume M.; Markus, Nora M.; Shaw, Pamela J.; Ferraiuolo, Laura
Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis
CELL REPORTS
IF6.9
2019-02-0161
OAAI
Cooper-Knock, Johnathan; Moll, Tobias; Ramesh, Tennore; Castelli, Lydia; Beer, Alexander; Robins, Henry; Fox, Ian; Niedermoser, Isabell; Van Damme, Philip; Moisse, Matthieu; Robberecht, Wim; Hardiman, Orla; Panades, Monica P.; Assialioui, Abdelilah; Mora, Jesus S.; Basak, A. Nazli; Morrison, Karen E.; Shaw, Christopher E.; Al-Chalabi, Ammar; Landers, John E.; Wyles, Matthew; Heath, Paul R.; Higginbottom, Adrian; Walsh, Theresa; Kazoka, Mbombe; McDermott, Christopher J.; Hautbergue, Guillaume M.; Kirby, Janine; Shaw, Pamela J.

研究方向

暂未获取到该数据
P
Pamela J. Shaw
H 指数:118论文数:879被引数:5.4万
S
Stuart A. Wilson
H 指数:40论文数:101被引数:6,086
L
Lydia M. Castelli
H 指数:24论文数:72被引数:2,013
M
Mimoun Azzouz
H 指数:38论文数:126被引数:5,504
L
Laura Ferraiuolo
H 指数:36论文数:125被引数:6,983
A
Adrian Higginbottom
H 指数:37论文数:122被引数:5,679
J
Johnathan Cooper‐Knock
H 指数:40论文数:181被引数:7,596
J
Janine Kirby
H 指数:51论文数:126被引数:1.1万
M
Monika A. Myszczynska
H 指数:12论文数:35被引数:1,748
Y
Ya-Hui Lin
H 指数:9论文数:30被引数:489