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L

Laura Ferraiuolo

University of Sheffield
H指数:36
被引数:6,949

个人简介

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工作经历

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荣誉奖项

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M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis

M102激活NRF2和HSF1转录因子通路，并在肌萎缩侧索硬化症的细胞和动物模型中具有神经保护作用。

Molecular Neurodegeneration
IF17.5
2025-11-060
OAAI
Amy F. Keerie; Raquel Rua Martins; Chloe F. Allen; Katie Bowden; Sufana Al Mashhadi; Thomas Marlow; Monika Myszczynska; Nikitha Thakur; Selina N. Beal; Allan Shaw; Shivani Suresh; Scott N. McKinnon; Johnathan Cooper-Knock; Ryan J. H. West; Sam Bonsall; Alex Daniel; Tyler Wells; Vedanth Kumar; Brittany C. S. Ellis; Maureen Higgins; Albena T. Dinkova-Kostova; Tatyana A. Shelkovnikova; Ira N. Kalfus; Ning Shan; Pamela J. Shaw; Laura Ferraiuolo; Richard J. Mead
Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47
EMBO MOLECULAR MEDICINE
IF8.3
2024-10-020
OAAI
Wiseman, Jessica P.; Scarrott, Joseph M.; Alves-Cruzeiro, Joao; Saffari, Afshin; Boger, Cedric; Karyka, Evangelia; Dawes, Emily; Davies, Alexandra K.; Marchi, Paolo M.; Graves, Emily; Fernandes, Fiona; Yang, Zih-Liang; Coldicott, Ian; Hirst, Jennifer; Webster, Christopher P.; Highley, J. Robin; Hackett, Neil; Angyal, Adrienn; de Silva, Thushan; Higginbottom, Adrian; Shaw, Pamela J.; Ferraiuolo, Laura; Ebrahimi-Fakhari, Darius; Azzouz, Mimoun
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease
NATURE COMMUNICATIONS
IF15.7
2024-06-014
OAAI
Xia, Zengjie; Prescott, Emily E.; Urbanek, Agnieszka; Wareing, Hollie E.; King, Marianne C.; Olerinyova, Anna; Dakin, Helen; Leah, Tom; Barnes, Katy A.; Matuszyk, Martyna M.; Dimou, Eleni; Hidari, Eric; Zhang, Yu P.; Lam, Jeff Y. L.; Danial, John S. H.; Strickland, Michael R.; Jiang, Hong; Thornton, Peter; Crowther, Damian C.; Ohtonen, Sohvi; Gomez-Budia, Mireia; Bell, Simon M.; Ferraiuolo, Laura; Mortiboys, Heather; Higginbottom, Adrian; Wharton, Stephen B.; Holtzman, David M.; Malm, Tarja; Ranasinghe, Rohan T.; Klenerman, David; De, Suman
Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis

线粒体功能的罕见和常见遗传决定因素决定了肌萎缩侧索硬化的严重程度，但没有风险

HELIYON
IF3.6
2024-02-013
OAAI
Harvey, Calum; Weinreich, Marcel; Lee, James A. K.; Shaw, Allan C.; Ferraiuolo, Laura; Mortiboys, Heather; Zhang, Sai; Hop, Paul J.; Zwamborn, Ramona A. J.; van Eijk, Kristel; Julian, Thomas H.; Moll, Tobias; Iacoangeli, Alfredo; Al Khleifat, Ahmad; Quinn, John P.; Pfaff, Abigail L.; Koks, Sulev; Poulton, Joanna; Battle, Stephanie L.; Arking, Dan E.; Snyder, Michael P.; Veldink, Jan H.; Kenna, Kevin P.; Shaw, Pamela J.; Cooper-Knock, Johnathan
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins

阻断C9ORF72-repeat RNA核输出的细胞渗透肽可降低二肽重复蛋白的神经毒性作用

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-03-016
OA
Castelli, Lydia M.; Lin, Ya-Hui; Sanchez-Martinez, Alvaro; Gul, Aytac; Imran, Kamallia Mohd; Higginbottom, Adrian; Upadhyay, Santosh Kumar; Markus, Nora M.; Martins, Raquel Rua; Cooper-Knock, Johnathan; Montmasson, Claire; Cohen, Rebecca; Walton, Amy; Bauer, Claudia S.; De Vos, Kurt J.; Mead, Richard J.; Azzouz, Mimoun; Dominguez, Cyril; Ferraiuolo, Laura; Shaw, Pamela J.; Whitworth, Alexander J.; Hautbergue, Guillaume M.
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation

TMEM106B的丢失通过破坏自噬体成熟来加剧C9ALS/FTD DPR病理

FRONTIERS IN CELLULAR NEUROSCIENCE
IF4
2022-12-166
OAAI
Bauer, Claudia S.; Webster, Christopher P.; Shaw, Allan C.; Kok, Jannigje R.; Castelli, Lydia M.; Lin, Ya-Hui; Smith, Emma F.; Illanes-Alvarez, Francisco; Higginbottom, Adrian; Shaw, Pamela J.; Azzouz, Mimoun; Ferraiuolo, Laura; Hautbergue, Guillaume M.; Grierson, Andrew J.; De Vos, Kurt J.
Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS

在ALS的体外模型中，由间充质干细胞分泌的细胞外囊泡穿梭的micro-rna抑制星形胶质细胞的病理激活并支持神经保护

CELLS
IF5.2
2022-12-0420
OAAI
Provenzano, Francesca; Nyberg, Sophie; Giunti, Debora; Torazza, Carola; Parodi, Benedetta; Bonifacino, Tiziana; Usai, Cesare; Kerlero de Rosbo, Nicole; Milanese, Marco; Uccelli, Antonio; Shaw, Pamela J.; Ferraiuolo, Laura; Bonanno, Giambattista
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

EXOSC2的低表达可防止临床新型冠状病毒肺炎并阻止SARS-CoV-2复制

LIFE SCIENCE ALLIANCE
IF2.9
2022-10-141
OAAI
Moll, Tobias; Odon, Valerie; Harvey, Calum; Collins, Mark O.; Peden, Andrew; Franklin, John; Graves, Emily; Marshall, Jack N. G.; Souza, Cleide dos Santos; Zhang, Sai; Castelli, Lydia; Hautbergue, Guillaume; Azzouz, Mimoun; Gordon, David; Krogan, Nevan; Ferraiuolo, Laura; Snyder, Michael P.; Shaw, Pamela J.; Rehwinkel, Jan; Cooper-Knock, Johnathan
C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
LIFE SCIENCE ALLIANCE
IF2.9
2022-05-137
OAAI
Marchi, Paolo M.; Marrone, Lara; Brasseur, Laurent; Coens, Audrey; Webster, Christopher P.; Bousset, Luc; Destro, Marco; Smith, Emma F.; Walther, Christa G.; Alfred, Victor; Marroccella, Raffaele; Graves, Emily J.; Robinson, Darren; Shaw, Allan C.; Wan, Lai Mei; Grierson, Andrew J.; Ebbens, Stephen J.; De Vos, Kurt J.; Hautbergue, Guillaume M.; Ferraiuolo, Laura; Melki, Ronald; Azzouz, Mimoun
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
MOLECULAR NEURODEGENERATION
IF17.5
2021-08-1014
OAAI
Castelli, Lydia M.; Cutillo, Luisa; Souza, Cleide Dos Santos; Sanchez-Martinez, Alvaro; Granata, Ilaria; Lin, Ya-Hui; Myszczynska, Monika A.; Heath, Paul R.; Livesey, Matthew R.; Ning, Ke; Azzouz, Mimoun; Shaw, Pamela J.; Guarracino, Mario R.; Whitworth, Alexander J.; Ferraiuolo, Laura; Milo, Marta; Hautbergue, Guillaume M.

研究方向

暂未获取到该数据
P
Pamela J. Shaw
H 指数:118论文数:879被引数:5.4万
G
Guillaume M. Hautbergue
H 指数:34论文数:113被引数:5,833
M
Monika A. Myszczynska
H 指数:12论文数:35被引数:1,738
P
Paul R. Heath
H 指数:53论文数:202被引数:9,399
A
Adrian Higginbottom
H 指数:37论文数:122被引数:5,668
M
Mimoun Azzouz
H 指数:38论文数:126被引数:5,492
B
Brian K. Kaspar
H 指数:60论文数:187被引数:1.9万
K
Kathrin Meyer
H 指数:32论文数:143被引数:7,238
H
Heather Mortiboys
H 指数:31论文数:102被引数:4,152
L
Lydia M. Castelli
H 指数:24论文数:72被引数:2,009