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M

Mimoun Azzouz

University of Sheffield
H指数:38
被引数:5,492

个人简介

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教育背景

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工作经历

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荣誉奖项

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Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47
EMBO MOLECULAR MEDICINE
IF8.3
2024-10-020
OAAI
Wiseman, Jessica P.; Scarrott, Joseph M.; Alves-Cruzeiro, Joao; Saffari, Afshin; Boger, Cedric; Karyka, Evangelia; Dawes, Emily; Davies, Alexandra K.; Marchi, Paolo M.; Graves, Emily; Fernandes, Fiona; Yang, Zih-Liang; Coldicott, Ian; Hirst, Jennifer; Webster, Christopher P.; Highley, J. Robin; Hackett, Neil; Angyal, Adrienn; de Silva, Thushan; Higginbottom, Adrian; Shaw, Pamela J.; Ferraiuolo, Laura; Ebrahimi-Fakhari, Darius; Azzouz, Mimoun
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins

阻断C9ORF72-repeat RNA核输出的细胞渗透肽可降低二肽重复蛋白的神经毒性作用

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-03-016
OA
Castelli, Lydia M.; Lin, Ya-Hui; Sanchez-Martinez, Alvaro; Gul, Aytac; Imran, Kamallia Mohd; Higginbottom, Adrian; Upadhyay, Santosh Kumar; Markus, Nora M.; Martins, Raquel Rua; Cooper-Knock, Johnathan; Montmasson, Claire; Cohen, Rebecca; Walton, Amy; Bauer, Claudia S.; De Vos, Kurt J.; Mead, Richard J.; Azzouz, Mimoun; Dominguez, Cyril; Ferraiuolo, Laura; Shaw, Pamela J.; Whitworth, Alexander J.; Hautbergue, Guillaume M.
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation

TMEM106B的丢失通过破坏自噬体成熟来加剧C9ALS/FTD DPR病理

FRONTIERS IN CELLULAR NEUROSCIENCE
IF4
2022-12-166
OAAI
Bauer, Claudia S.; Webster, Christopher P.; Shaw, Allan C.; Kok, Jannigje R.; Castelli, Lydia M.; Lin, Ya-Hui; Smith, Emma F.; Illanes-Alvarez, Francisco; Higginbottom, Adrian; Shaw, Pamela J.; Azzouz, Mimoun; Ferraiuolo, Laura; Hautbergue, Guillaume M.; Grierson, Andrew J.; De Vos, Kurt J.
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

EXOSC2的低表达可防止临床新型冠状病毒肺炎并阻止SARS-CoV-2复制

LIFE SCIENCE ALLIANCE
IF2.9
2022-10-141
OAAI
Moll, Tobias; Odon, Valerie; Harvey, Calum; Collins, Mark O.; Peden, Andrew; Franklin, John; Graves, Emily; Marshall, Jack N. G.; Souza, Cleide dos Santos; Zhang, Sai; Castelli, Lydia; Hautbergue, Guillaume; Azzouz, Mimoun; Gordon, David; Krogan, Nevan; Ferraiuolo, Laura; Snyder, Michael P.; Shaw, Pamela J.; Rehwinkel, Jan; Cooper-Knock, Johnathan
C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
LIFE SCIENCE ALLIANCE
IF2.9
2022-05-137
OAAI
Marchi, Paolo M.; Marrone, Lara; Brasseur, Laurent; Coens, Audrey; Webster, Christopher P.; Bousset, Luc; Destro, Marco; Smith, Emma F.; Walther, Christa G.; Alfred, Victor; Marroccella, Raffaele; Graves, Emily J.; Robinson, Darren; Shaw, Allan C.; Wan, Lai Mei; Grierson, Andrew J.; Ebbens, Stephen J.; De Vos, Kurt J.; Hautbergue, Guillaume M.; Ferraiuolo, Laura; Melki, Ronald; Azzouz, Mimoun
SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction

SPG15蛋白缺陷处于溶酶体异常，脂质代谢改变和突触功能障碍之间的十字路口

HUMAN MOLECULAR GENETICS
IF3.2
2022-03-218
OAAI
Marrone, Lara; Marchi, Paolo M.; Webster, Christopher P.; Marroccella, Raffaele; Coldicott, Ian; Reynolds, Steven; Alves-Cruzeiro, Joao; Yang, Zih-Liang; Higginbottom, Adrian; Khundadze, Mukhran; Shaw, Pamela J.; Huebner, Christian A.; Livesey, Matthew R.; Azzouz, Mimoun
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
MOLECULAR NEURODEGENERATION
IF17.5
2021-08-1014
OAAI
Castelli, Lydia M.; Cutillo, Luisa; Souza, Cleide Dos Santos; Sanchez-Martinez, Alvaro; Granata, Ilaria; Lin, Ya-Hui; Myszczynska, Monika A.; Heath, Paul R.; Livesey, Matthew R.; Ning, Ke; Azzouz, Mimoun; Shaw, Pamela J.; Guarracino, Mario R.; Whitworth, Alexander J.; Ferraiuolo, Laura; Milo, Marta; Hautbergue, Guillaume M.

研究方向

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P
Pamela J. Shaw
H 指数:118论文数:879被引数:5.4万
G
Guillaume M. Hautbergue
H 指数:34论文数:113被引数:5,833
A
Adrian Higginbottom
H 指数:37论文数:122被引数:5,668
L
Laura Ferraiuolo
H 指数:36论文数:125被引数:6,949
K
Ke Ning
H 指数:41论文数:192被引数:5,938
C
Christopher P Webster
H 指数:11论文数:20被引数:935
N
Nicholas D. Mazarakis
H 指数:39论文数:81被引数:5,938
L
Lydia M. Castelli
H 指数:24论文数:72被引数:2,009
P
Paolo Marchi
H 指数:11论文数:28被引数:456
E
Evangelia Karyka
H 指数:11论文数:18被引数:718