Irina G. Tikhonova - Publications, H-index & Citations

Irina G. Tikhonova

queen's university belfast

33H指数

143论文数

2.8K被引数

收录论文 58

发表时间

Steric control of signaling bias in the immunometabolic receptor GPR84 GPR84免疫代谢受体信号偏倚的立体控制

Nature Communications

IF15.7

2026-09-05

OAAI

Pinqi Wang; Xuan Zhang; Abdul-Akim Guseinov; Laura Jenkins; Carl von Hallerstein; Jonathan D. Colburn; Rowan Ives; Vincent B. Luscombe; Sara Marsango; Listiana Oktavia; Arun Raja; David R. Greaves; Philip C. Biggin; Graeme Milligan; Cheng Zhang; Irina G. Tikhonova; Angela J. Russell

Structural basis and physiological significance of non-canonical Gs coupling to the melatonin MT1 receptor 非经典Gs偶联至褪黑素MT1受体的结构基础和生理意义

Nature Communications

IF15.7

2026-05-21

OAAI

Atsuro Oishi; Hiroyuki H. Okamoto; Keisuke Ikegami; Ronan McHugh; Bernard Masri; Tsukasa Kusakizako; Kazuhiro Kobayashi; Akifumi Takaki; Angeliki Karamitri; Erika Cecon; Julie Dam; Miki Nagase; Irina G. Tikhonova; Osamu Nureki; Ralf Jockers

Discovery; Structure–Activity Relationship; and Functional Characterization of a Chromenopyrrole Series as Orthosteric Antagonists of GPR84 发现；结构-活性关系；以及一种色烯吡咯系列作为GPR84正构拮抗剂的功能表征

Journal of Medicinal Chemistry

IF6.8

2026-03-23

OAAI

Michael A. Malone; Ruijing Yin; Yueming Li; Laura Jenkins; Abdul-Akim Guseinov; Sara Marsango; Mark Huggett; Margaret Huggett; Anna Boyle; Angus Morrison; Irina G. Tikhonova; Graeme Milligan; Andrew G. Jamieson

Structural and dynamic insights into agonist recognition and function of the thromboxane A2 receptor 血栓素A2受体激动剂识别与功能的结构和动态学见解

Nature Communications

IF15.7

2026-02-23

OAAI

Pawel Krawinski; Donna Matzov; Aoife Ryder; Kanhaya Lal; Dmitry S. Karlov; Georges Chalhoub; Eamon P. Mulvaney; B. Therese Kinsella; Peter J. McCormick; Martin Caffrey; Irina G. Tikhonova; Moran Shalev-Benami

Structural basis for the ligand recognition and signaling of free fatty acid receptors

SCIENCE ADVANCES

IF12.5

2024-01-12

OAAI

Zhang, Xuan; Guseinov, Abdul-Akim; Jenkins, Laura; Li, Kunpeng; Tikhonova, Irina G.; Milligan, Graeme; Zhang, Cheng

β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

ELIFE

IF0

2023-10-19

OAAI

Daly, Carole; Guseinov, Akim Abdul; Hahn, Hyunggu; Wright, Adam; Tikhonova, Irina G.; Thomsen, Alex Rojas Bie; Plouffe, Bianca

Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2+-activated potassium channels

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-03-01

OAAI

Dudem, Srikanth; Boon, Pei Xin; Mullins, Nicholas; McClafferty, Heather; Shipston, Michael J.; Wilkinson, Richard D. A.; Lobb, Ian; Sergeant, Gerard P.; Thornbury, Keith D.; Tikhonova, Irina G.; Hollywood, Mark A.

Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface from Molecular Dynamics Simulations and Quantum Chemical Calculations

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2022-09-30

OAAI

Ding, Tianyi; Karlov, Dmitry S.; Pino-Angeles, Almudena; Tikhonova, Irina G.

Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-08-10

OAAI

Mahindra, Amit; Jenkins, Laura; Marsango, Sara; Huggett, Mark; Huggett, Margaret; Robinson, Lindsay; Gillespie, Jonathan; Rajamanickam, Muralikrishnan; Morrison, Angus; McElroy, Stuart; Tikhonova, Irina G.; Milligan, Graeme; Jamieson, Andrew G.

Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-05-01

OAAI

Marsango, Sara; Ward, Richard J.; Jenkins, Laura; Butcher, Adrian J.; Al Mahmud, Zobaer; Dwomoh, Louis; Nagel, Falko; Schulz, Stefan; Tikhonova, Irina G.; Tobin, Andrew B.; Milligan, Graeme

Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction

ACS CENTRAL SCIENCE

IF10.4

2021-09-28

OAAI

Ciancetta, Antonella; Gill, Amandeep Kaur; Ding, Tianyi; Karlov, Dmitry S.; Chalhoub, George; McCormick, Peter J.; Tikhonova, Irina G.

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis

NATURE COMMUNICATIONS

IF15.7

2021-07-12

OAAI

Olatunji, Samir; Bowen, Katherine; Huang, Chia-Ying; Weichert, Dietmar; Singh, Warispreet; Tikhonova, Irina G.; Scanlan, Eoin M.; Olieric, Vincent; Caffrey, Martin

An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica

SCIENTIFIC REPORTS

IF3.9

2020-11-26

OAAI

Smith, David; Cwiklinski, Krystyna; Jewhurst, Heather; Tikhonova, Irina G.; Dalton, John P.

Fasciola hepatica Serine Protease Inhibitor Family (Serpins): Purposely crafted for regulating host proteases

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2020-08-06

OAAI

Verissimo, Carolina De Marco; Jewhurst, Heather L.; Tikhonova, Irina G.; Urbanus, Rolf T.; Maule, Aaron G.; Dalton, John P.; Cwiklinski, Krystyna

LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-01-13

OAAI

Dudem, Srikanth; Large, Roddy J.; Kulkarni, Shruti; McClafferty, Heather; Tikhonova, Irina G.; Sergeant, Gerard P.; Thornbury, Keith D.; Shipston, Michael J.; Perrino, Brian A.; Hollywood, Mark A.

Understanding Peptide Binding in Class A G Protein-Coupled Receptors

MOLECULAR PHARMACOLOGY

IF3

2019-11-01

OAAI

Tikhonova, Irina G.; Gigoux, Veronique; Fourmy, Daniel

The complex structure of bile salt hydrolase from Lactobacillus salivarius reveals the structural basis of substrate specificity

SCIENTIFIC REPORTS

IF3.9

2019-08-27

OAAI

Xu, Fuzhou; Hu, Xiao-Jian; Singh, Warispreet; Geng, Wenjing; Tikhonova, Irina G.; Lin, Jun

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 三个课程的配体分别与孤儿g蛋白偶联受体GPR84上的不同位点结合

SCIENTIFIC REPORTS

IF3.9

2017-12-20

OAAI

Al Mahmud, Zobaer; Jenkins, Laura; Ulven, Trond; Labeguere, Frederic; Gosmini, Romain; De Vos, Steve; Hudson, Brian D.; Tikhonova, Irina G.; Milligan, Graeme

Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2017-11-01

PREAI

Krasavin, Mikhail; Lukin, Alexei; Bakholdina, Anna; Zhurilo, Nikolay; Onopchenko, Oleksandra; Borysko, Petro; Zozulya, Sergey; Moore, Daniel; Tikhonova, Irina G.

The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif L-选择蛋白的细胞质尾部通过新的碱性结合基序与衔接蛋白复合物AP-1亚基 μ1A相互作用

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-04-01

OAAI

Dib, Karim; Tikhonova, Irina G.; Ivetic, Aleksandar; Schu, Peter

研究方向