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H

Heinz Jacobs

netherlands cancer institute
H指数:41
被引数:6,223

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DOT1L Shapes ncPRC1-Target Gene Repression to Maintain Germinal Center B-Cell Identity of Diffuse Large B-cell Lymphoma

DOT1L调控ncPRC1靶基因抑制以维持弥漫性大B细胞淋巴瘤的生发中心B细胞特性

Blood
IF23.1
2026-06-020
PRE
Camiel Göbel; Rachele Niccolai; Sebastian Gregoricchio; Marnix H. P. de Groot; Stijn Kneefel; Maaike Kreft; Hendrik J. Kuiken; Cor Lieftink; Nils Eickhoff; Liesbeth Hoekman; Onno Bleijerveld; Wilbert Zwart; Roderick L. Beijersbergen; Fred van Leeuwen; Heinz Jacobs
Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells

组蛋白甲基转移酶DOT1L维持细胞状态并限制CD8 T细胞的细胞毒性潜力

Science Advances
IF12.5
2025-12-120
OA
Muddassir Malik; Willem-Jan de Leeuw; Muhammad Assad Aslam; Eliza Mari Kwesi-Maliepaard; Teun van den Brand; Bram van den Broek; Maxime Kempers; Liesbeth Hoekman; Natalie Proost; Tibor van Welsem; Nikolina Bąbała; Elselien Frijlink; Elzo de Wit; Jannie Borst; Heinz Jacobs; Fred van Leeuwen
Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition

胆固醇生物合成作为对EZH2抑制不敏感的弥漫性大B细胞淋巴瘤的药物诱导易感靶点

Neoplasia
IF7.7
2025-10-270
OAAI
Rachele Niccolai; Camiel Göbel; Klevis Ndoj; Maaike Kreft; Hendrik J. Kuiken; Cor Lieftink; Ben Morris; Sietse D. Yska; Sebastian Hendrix; Bram van den Broek; Vincent Pappalardo; Marie José Kersten; Roderick L. Beijersbergen; Noam Zelcer; Fred van Leeuwen; Heinz Jacobs
Mammalian life depends on two distinct pathways of DNA damage tolerance

哺乳动物的生命依赖于两种不同的DNA损伤耐受途径

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2023-01-204
OAAI
Buoninfante, Olimpia Alessandra; Pilzecker, Bas; Spanjaard, Aldo; de Groot, Daniel; Prekovic, Stefan; Song, Ji-Ying; Lieftink, Cor; Ayidah, Matilda; Pritchard, Colin E. J.; Vivie, Judith; Mcgrath, Kathleen E.; Huijbers, Ivo J.; Philipsen, Sjaak; von Lindern, Marieke; Zwart, Wilbert; Beijersbergen, Roderick L.; Palish, James; van den Berk, Paul C. M.; Jacobs, Heinz
Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

Huwe1通过调节增殖支持b细胞发育，b细胞依赖性免疫，体细胞超突变和类别转换重组

FRONTIERS IN IMMUNOLOGY
IF5.9
2023-01-093
OAAI
Spanjaard, Aldo; Stratigopoulou, Maria; de Groot, Daniel; Aslam, Muhammad; van den Berk, Paul C. M.; Stappenbelt, Chantal; Ayidah, Matilda; Catsman, Joyce J. I.; Pardieck, Iris N.; Kreft, Maaike; Arens, Ramon; Guikema, Jeroen E. J.; Jacobs, Heinz
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability
CELL REPORTS
IF6.9
2022-11-019
PRE
Willemsen, Lisa; Prange, Koen H. M.; Neele, Annette E.; Van Roomen, Cindy P. A. A.; Gijbels, Marion; Griffith, Guillermo R.; Den Toom, Myrthe; Beckers, Linda; Siebeler, Ricky; Spann, Nathanael J.; Chen, Hung-Jen; Bosmans, Laura A.; Gorbatenko, Andrej; Van Wouw, Suzanne; Zelcer, Noam; Jacobs, Heinz; Van Leeuwen, Fred; De Winther, Menno P. J.
Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine
NUCLEIC ACIDS RESEARCH
IF13.1
2022-07-127
OAAI
Spanjaard, Aldo; Shah, Ronak; de Groot, Daniel; Buoninfante, Olimpia Alessandra; Morris, Ben; Lieftink, Cor; Pritchard, Colin; Zurcher, Lisa M.; Ormel, Shirley; Catsman, Joyce J., I; De Korte-Grimmerink, Renske; Siteur, Bjorn; Proost, Natalie; Boadum, Terry; van de Ven, Marieke; Song, Ji-Ying; Kreft, Maaike; van den Berk, Paul C. M.; Beijersbergen, Roderick L.; Jacobs, Heinz
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

组蛋白甲基转移酶DOT1L可防止抗原非依赖性分化并保护CD8 T细胞的表观遗传身份

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2020-08-0632
OAAI
Kwesi-Maliepaard, Eliza Mari; Aslam, Muhammad Assad; Alemdehy, Mir Farshid; van den Brand, Teun; McLean, Chelsea; Vlaming, Hanneke; van Welsem, Tibor; Korthout, Tessy; Lancini, Cesare; Hendriks, Sjoerd; Ahrends, Tomasz; van Dinther, Dieke; den Haan, Joke M. M.; Borst, Jannie; de Wit, Elzo; van Leeuwen, Fred; Jacobs, Heinz

研究方向

暂未获取到该数据
P
Paul C.M. van den Berk
H 指数:13论文数:28被引数:803
F
Fred van Leeuwen
H 指数:41论文数:126被引数:6,062
B
Bas Pilzecker
H 指数:8论文数:21被引数:743
A
Aldo Spanjaard
H 指数:5论文数:10被引数:441
P
Peter H.L. Krijger
H 指数:26论文数:55被引数:4,854
M
Muhammad Assad Aslam
H 指数:13论文数:34被引数:551
O
Olimpia Alessandra Buoninfante
H 指数:7论文数:21被引数:309
P
Petra Langerak
H 指数:12论文数:36被引数:1,250
R
Roderick L. Beijersbergen
H 指数:59论文数:361被引数:2.3万
N
Niels de Wind
H 指数:44论文数:137被引数:5,915