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F

Fred van Leeuwen

netherlands cancer institute
H指数:41
被引数:6,062

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DOT1L Shapes ncPRC1-Target Gene Repression to Maintain Germinal Center B-Cell Identity of Diffuse Large B-cell Lymphoma

DOT1L调控ncPRC1靶基因抑制以维持弥漫性大B细胞淋巴瘤的生发中心B细胞特性

Blood
IF23.1
2026-06-020
PRE
Camiel Göbel; Rachele Niccolai; Sebastian Gregoricchio; Marnix H. P. de Groot; Stijn Kneefel; Maaike Kreft; Hendrik J. Kuiken; Cor Lieftink; Nils Eickhoff; Liesbeth Hoekman; Onno Bleijerveld; Wilbert Zwart; Roderick L. Beijersbergen; Fred van Leeuwen; Heinz Jacobs
Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells

组蛋白甲基转移酶DOT1L维持细胞状态并限制CD8 T细胞的细胞毒性潜力

Science Advances
IF12.5
2025-12-120
OA
Muddassir Malik; Willem-Jan de Leeuw; Muhammad Assad Aslam; Eliza Mari Kwesi-Maliepaard; Teun van den Brand; Bram van den Broek; Maxime Kempers; Liesbeth Hoekman; Natalie Proost; Tibor van Welsem; Nikolina Bąbała; Elselien Frijlink; Elzo de Wit; Jannie Borst; Heinz Jacobs; Fred van Leeuwen
Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition

胆固醇生物合成作为对EZH2抑制不敏感的弥漫性大B细胞淋巴瘤的药物诱导易感靶点

Neoplasia
IF7.7
2025-10-270
OAAI
Rachele Niccolai; Camiel Göbel; Klevis Ndoj; Maaike Kreft; Hendrik J. Kuiken; Cor Lieftink; Ben Morris; Sietse D. Yska; Sebastian Hendrix; Bram van den Broek; Vincent Pappalardo; Marie José Kersten; Roderick L. Beijersbergen; Noam Zelcer; Fred van Leeuwen; Heinz Jacobs
DOT1L regulates chromatin reorganization and gene expression during sperm differentiation

DOT1L在精子分化过程中调节染色质重组和基因表达

EMBO REPORTS
IF6.2
2023-04-268
OA
Blanco, Melina; El Khattabi, Laila; Gobe, Clara; Crespo, Marion; Coulee, Manon; de la Iglesia, Alberto; Ialy-Radio, Come; Lapoujade, Clementine; Givelet, Maelle; Delessard, Marion; Seller-Corona, Ivan; Yamaguchi, Kosuke; Vernet, Nadege; Van Leeuwen, Fred; Lermine, Alban; Okada, Yuki; Daveau, Romain; Oliva, Rafael; Fouchet, Pierre; Ziyyat, Ahmed; Pflieger, Delphine; Cocquet, Julie
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability
CELL REPORTS
IF6.9
2022-11-019
PRE
Willemsen, Lisa; Prange, Koen H. M.; Neele, Annette E.; Van Roomen, Cindy P. A. A.; Gijbels, Marion; Griffith, Guillermo R.; Den Toom, Myrthe; Beckers, Linda; Siebeler, Ricky; Spann, Nathanael J.; Chen, Hung-Jen; Bosmans, Laura A.; Gorbatenko, Andrej; Van Wouw, Suzanne; Zelcer, Noam; Jacobs, Heinz; Van Leeuwen, Fred; De Winther, Menno P. J.
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

组蛋白甲基转移酶DOT1L可防止抗原非依赖性分化并保护CD8 T细胞的表观遗传身份

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2020-08-0632
OAAI
Kwesi-Maliepaard, Eliza Mari; Aslam, Muhammad Assad; Alemdehy, Mir Farshid; van den Brand, Teun; McLean, Chelsea; Vlaming, Hanneke; van Welsem, Tibor; Korthout, Tessy; Lancini, Cesare; Hendriks, Sjoerd; Ahrends, Tomasz; van Dinther, Dieke; den Haan, Joke M. M.; Borst, Jannie; de Wit, Elzo; van Leeuwen, Fred; Jacobs, Heinz

研究方向

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T
Tibor van Welsem
H 指数:20论文数:70被引数:2,263
H
Hanneke Vlaming
H 指数:10论文数:25被引数:548
H
Heinz Jacobs
H 指数:41论文数:126被引数:6,223
H
Haico van Attikum
H 指数:53论文数:136被引数:9,225
M
Maarten Altelaar
H 指数:60论文数:414被引数:1.2万
E
Eliza Mari Kwesi‐Maliepaard
H 指数:6论文数:16被引数:209
F
Floor Frederiks
H 指数:8论文数:18被引数:533
T
Tineke L. Lenstra
H 指数:27论文数:70被引数:2,631
T
Tessy Korthout
H 指数:8论文数:18被引数:230
L
Liesbeth Hoekman
H 指数:17论文数:114被引数:1,023