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S

Senthilnath Lakshmanachetty

university of california
H指数:8
被引数:263

个人简介

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荣誉奖项

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Brain-sensing synNotch–CAR T cells enable precise targeting and clearance of diffuse midline glioma in multiple preclinical models

脑感知synNotch–CAR T细胞在多种预临床模型中实现对弥漫性中线胶质瘤的精确靶向和清除

Science Translational Medicine
IF14.6
2026-10-280
PRE
Senthilnath Lakshmanachetty; Milos S. Simic; Payal B. Watchmaker; Robert Zhu; Takahide Nejo; Maggie Colton Cove; Jeffrey Haegelin; Haoyu Long; Aishi Zhao; Alejandra Bergquist; Wei Yu; Brianna Wong; Marco Gallus; Ricardo Almeida; Joanna P. Phillips; Wendell A. Lim; Hideho Okada
Role of LRRC25 in local and systemic immunosuppression and its reversal

LRRC25在局部和系统性免疫抑制及其逆转中的作用

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Zamler, Daniel B.; Lakshmanachetty, Senthilnath; Stevers, Nicholas O.; Chan, Gary K. L.; Liu, Jerry; Chen, Lee; Lerman, Ben; Kwok, Darwin W.; Hong, Chibo; Cove, Maggie Colton; Gallus, Marco; Mathur, Radhika; Dabaco, Cristina; Rodino, Jessica; Schupp, Patrick G.; Shai, Anny; Phillips, Joanna J.; Okada, Hideho; Oldham, Michael C.; Costello, Joseph F.
TARGETING GLIOMA-NEURONAL CIRCUIT REMODELING TO OVERCOME IMMUNOSUPPRESSION: FUNCTIONAL AND THERAPEUTIC INSIGHTS

靶向胶质瘤-神经元回路重塑以克服免疫抑制：功能性与治疗性见解

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Nejo, Takahide; Krishna, Saritha; Yamamichi, Akane; Lakshmanachetty, Senthilnath; Jimenez, Christian; Young, Jacob; Phyu, Su; Phung, Lan; Gallus, Marco; Maldonado, Gabriella; Okada, Kaori; Watchmaker, Payal; Daniel, Andy; Hervey-Jumper, Shawn; Okada, Hideho
Spatially Resolved Antigenic Landscapes In Low-grade Glioma Reveal Targets For Personalized Immunotherapy

低级别胶质瘤的空间分辨抗原景观揭示个性化免疫治疗靶点

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Kwok, Darwin; Zhang, Michael; Wang, Cliff; Cove, Maggie Colton; Hong, Chibo; Stevers, Nicholas; Lerman, Benjamin; Lakshmanachetty, Senthilnath; Borrman, Tyler; Pan, Zheng; Yuen, Benjamin; Peng, Songming; Nguyen, Diana; Martin, Michael; Hilz, Stephanie; Phillips, Joanna; Shai, Anny; Bush, Nancy Ann Oberheim; Hervey-Jumper, Shawn; Mcdermott, Michael; Mandl, Stefanie; Okada, Hideho; Costello, Joseph
Focused ultrasound-mediated blood-brain barrier disruption, combined with antigen-presenting cell activation, promotes CNS antigen-specific T cell immunity and bypasses immunotherapy resistance mechanism in malignant brain tumors

聚焦超声介导的血脑屏障破坏，结合抗原提呈细胞激活，促进中枢神经系统抗原特异性T细胞免疫，并绕过恶性脑肿瘤的免疫疗法耐药机制。

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Gallus, Marco; Yamamichi, Akane; Arrieta, Victor Andres; Nejo, Takahide; Phung, Lan; Saijo, Atsuro; Chuntova, Pavlina; Lu, Jianwen; Phyu, Su; Zhao, Aishi; Okada, Kaori; Watchmaker, Payal; Haegelin, Jeffrey; Lakshmanachetty, Senthilnath; Habashy, Karl; Canney, Michael; Sonabend, Adam M.; Okada, Hideho
TUMOR-WIDE RNA SPLICING ABERRATIONS GENERATE IMMUNOGENIC PUBLIC NEOANTIGENS IN GLIOBLASTOMAS AND OTHER CANCER TYPES
NEURO-ONCOLOGY
IF13.4
2024-11-110
PRE
Kwok, Darwin; Stevers, Nicholas; Etxeberria, Inaki; Nejo, Takahide; Cove, Maggie Colton; Chen, Lee; Jung, Jangham; Okada, Kaori; Lakshmanachetty, Senthilnath; Gallus, Marco; Barpanda, Abhilash; Hong, Chibo; Chan, Gary; Liu, Jerry; Wu, Samuel; Ramos, Emilio; Yamamichi, Akane; Watchmaker, Payal; Ogino, Hirokazu; Saijo, Atsuro; Du, Aidan; Grishanina, Nadia; Woo, James; Diaz, Aaron; Chang, Susan; Phillips, Joanna; Wiita, Arun; Klebanoff, Christopher; Costello, Joseph; Okada, Hideho
LOW-INTENSITY PULSED ULTRASOUND COMBINED WITH POLY-ICLC AND INTERLEUKIN-2 UNLOCKS THE IMMUNE PRIVILEGE OF THE BRAIN BY PROMOTING EPITOPE SPREADING AND ACTIVATION OF CNS-SPECIFIC NAÏVE T CELLS

低强度脉冲超声联合poly-iclc和INTERLEUKIN-2通过促进CNS特异性初始T细胞的表位扩散和激活来解锁大脑的免疫特权

NEURO-ONCOLOGY
IF13.4
2024-11-110
PRE
Gallus, Marco; Yamamichi, Akane; Arrieta, Victor Andres; Saijo, Atsuro; Chuntova, Pavlina; Phyu, Su; Phung, Lan; Haegelin, Jeffrey; Long, Haoyu; Lakshmanachetty, Senthilnath; Nejo, Takahide; Okada, Kaori; Chen, Li; Habashy, Karl; Gould, Andrew; Amidei, Christina; Chang, Catalina Lee; Stupp, Roger; Canney, Michael; Sonabend, Adam M.; Okada, Hideho
T-CELL THERAPY COMBINED WITH LOW-INTENSITY PULSED FOCUSED ULTRASOUND, MICROBUBBLES AND POLY-ICLC PROMOTES THE PRESENTATION OF BRAIN-DERIVED ANTIGENS, BREAKING CNS TOLERANCE AND INDUCING ACTIVE T-CELL RESPONSES
NEURO-ONCOLOGY
IF13.4
2024-10-170
PRE
Gallus, M.; Yamamichi, A.; Arrieta, V. Andres; Saijo, A.; Chuntova, P.; Haegelin, J.; Phyu, S.; Phung, L.; Long, J.; Lakshmanachetty, S.; Nejo, T.; Okada, K.; Chen, L.; Habashy, K.; Gould, A.; Amidei, C.; Chang, C.; Stupp, R.; Canney, M.; Sonabend, A.; Okada, H.
Novel public and tumor-wide neoantigens arising from clonal aberrant splicing events drive tumor-specific T-cell responses across diverse cancer types
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Kwok, Darwin; Stevers, Nicholas O.; Nejo, Takahide; Chen, Lee H.; Etxeberria, Inaki; Jung, Jangham; Okada, Kaori; Cove, Maggie Colton; Lakshmanachetty, Senthilnath; Gallus, Marco; Barpanda, Abhilash; Hong, Chibo; Chan, Gary Kl; Wu, Samuel H.; Ramos, Emilio; Yamamichi, Akane; Liu, Jerry Yz; Watchmaker, Payal; Ogino, Hirokazu; Saijo, Atsuro; Du, Aidan; Grishanina, Nadia; Woo, James; Diaz, Aaron; Chang, Susan M.; Phillips, Joanna J.; Wiita, Arun P.; Klebanoff, Christopher A.; Costello, Joseph F.; Okada, Hideho
Low-intensity pulsed ultrasound enhances the presentation of brain-derived antigens by facilitating the migration of antigen-presenting cells from the brain to the periphery
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Gallus, Marco; Arrieta, Victor Andres; Saijo, Atsuro; Chuntova, Pavlina; Yamamichi, Akane; Haegelin, Jeffrey; Phyu, Su; Phung, Lan; Amir-Kabirian, Shayan A.; Lakshmanachetty, Senthilnath; Chen, Li; Habashy, Karl; Gould, Andrew; Amidei, Christina; Chang, Catalina Lee; Stupp, Roger; Canney, Michael; Okada, Hideho
Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

在胶质瘤中发现肿瘤特异性选择性剪接衍生的细胞表面抗原的挑战

SCIENTIFIC REPORTS
IF3.9
2024-03-167
OAAI
Nejo, Takahide; Wang, Lin; Leung, Kevin K.; Wang, Albert; Lakshmanachetty, Senthilnath; Gallus, Marco; Kwok, Darwin W.; Hong, Chibo; Chen, Lee H.; Carrera, Diego A.; Zhang, Michael Y.; Stevers, Nicholas O.; Maldonado, Gabriella C.; Yamamichi, Akane; Watchmaker, Payal B.; Naik, Akul; Shai, Anny; Phillips, Joanna J.; Chang, Susan M.; Wiita, Arun P.; Wells, James A.; Costello, Joseph F.; Diaz, Aaron A.; Okada, Hideho

研究方向

暂未获取到该数据
H
Hideho Okada
H 指数:68论文数:515被引数:1.7万
T
Takahide Nejo
H 指数:17论文数:120被引数:983
A
Akane Yamamichi
H 指数:15论文数:92被引数:732
P
Payal Watchmaker
H 指数:15论文数:81被引数:2,791
M
Marco Gallus
H 指数:15论文数:56被引数:817
A
Atsuro Saijo
H 指数:13论文数:73被引数:664
K
Kaori Okada
H 指数:14论文数:82被引数:839
N
Nicholas Stevers
H 指数:14论文数:75被引数:737
D
Darwin Kwok
H 指数:7论文数:37被引数:383
J
J Costello
H 指数:76论文数:723被引数:3.7万