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NRF2 supports non-small cell lung cancer growth independently of CBP/p300-enhanced glutathione synthesis NRF2支持非小细胞肺癌的生长，且该作用独立于CBP/p300增强的谷胱甘肽合成。 Conrad, Ryan J.; Mondo, James A.; Wang, Mike Lingjue; Liu, Peter S.; Lai, Zijuan; Choudhury, Feroza K.; Li, Qingling; Wong, Weng Ruh; Lee, James; Shanahan, Frances; Lin, Eva; Martin, Scott; Rudolph, Joachim; Moffat, John G.; Sangaraju, Dewakar; Sandoval, Wendy; Sterne-Weiler, Timothy; Foster, Scott A. 分享 收藏
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification Haag, Simone M.; Xie, Shiqi; Eidenschenk, Celine; Fortin, Jean-Philippe; Callow, Marinella; Costa, Mike; Lun, Aaron; Cox, Chris; Wu, Sunny Z.; Pradhan, Rachana N.; Lock, Jaclyn; Kuhn, Julia A.; Holokai, Loryn; Thai, Minh; Freund, Emily; Nissenbaum, Ariane; Keir, Mary; Bohlen, Christopher J.; Martin, Scott; Geiger-Schuller, Kathryn; Hejase, Hussein A.; Yaspan, Brian L.; Carlos, Sandra Melo; Turley, Shannon J.; Murthy, Aditya 分享 收藏
The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated anti-tumor immunity Lim, Junghyun; Rodriguez, Ryan; Williams, Katherine; Silva, John; Gutierrez, Alan; Tyler, Paul; Baharom, Faezzah; Sun, Tao; Lin, Eva; Martin, Scott; Kayser, Brandon; Johnston, Robert J.; Mellman, Ira; Delamarre, Lelia; West, Nathaniel; Mueller, Soren; Qu, Yan; Heger, Klaus 分享 收藏
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance 变构泛TEAD抑制剂阻断致癌YAP/TAZ信号传导并克服KRAS G12C抑制剂抗性 Hagenbeek, Thijs J. J.; Zbieg, Jason R. R.; Hafner, Marc; Mroue, Rana; Lacap, Jennifer A. A.; Sodir, Nicole M. M.; Noland, Cameron L. L.; Afghani, Shervin; Kishore, Ayush; Bhat, Kamakoti P. P.; Yao, Xiaosai; Schmidt, Stephen; Clausen, Saundra; Steffek, Micah; Lee, Wendy; Beroza, Paul; Martin, Scott; Lin, Eva; Fong, Rina; Di Lello, Paola; Kubala, Marta H. H.; Yang, Michelle N. -Y.; Lau, Jeffrey T. T.; Chan, Emily; Arrazate, Alfonso; An, Le; Levy, Elizabeth; Lorenzo, Maria N. N.; Lee, Ho-June; Pham, Trang H. H.; Modrusan, Zora; Zang, Richard; Chen, Yi-Chen; Kabza, Michal; Ahmed, Musaddeque; Li, Jason; Chang, Matthew T. T.; Maddalo, Danilo; Evangelista, Marie; Ye, Xin; Crawford, James J. J.; Dey, Anwesha 分享 收藏
Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling Li, Dandan; Miermont, Anne M.; Sable, Rushikesh; Quadri, Humair S.; Griner, Lesley A. Mathews; Martin, Scott E.; Odzorig, Taivan; De, Soumita; Ferrer, Marc; Powers, Astin S.; Hewitt, Stephen M.; Rudloff, Udo 分享 收藏
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study Lasater, Elisabeth A.; Amin, Dhara N.; Bannerji, Rajat; Mali, Raghuveer Singh; Barrett, Kathy; Rys, Ryan N.; Oeh, Jason; Lin, Eva; Sterne-Weiler, Tim; Ingalla, Ellen Rei; Go, MaryAnn; Yu, Shang-Fan; Krem, Maxwell M.; Arthur, Chris; Hahn, Uwe; Johnston, Anna; Karur, Vinit; Khan, Nadia; Marlton, Paula; Phillips, Tycel; Gritti, Giuseppe; Seymour, John F.; Tani, Monica; Yuen, Sam; Martin, Scott; Chang, Matthew T.; Rose, Christopher M.; Pham, Victoria C.; Polson, Andrew G.; Chang, YiMeng; Wever, Claudia; Johnson, Nathalie A.; Jiang, Yanwen; Hirata, Jamie; Sampath, Deepak; Musick, Lisa; Flowers, Christopher R.; Wertz, Ingrid E. 分享 收藏
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers Cantley, Jennifer; Ye, Xiaofen; Rousseau, Emma; Januario, Tom; Hamman, Brian D.; Rose, Christopher M.; Cheung, Tommy K.; Hinkle, Trent; Soto, Leofal; Quinn, Connor; Harbin, Alicia; Bortolon, Elizabeth; Chen, Xin; Haskell, Roy; Lin, Eva; Yu, Shang-Fan; Del Rosario, Geoff; Chan, Emily; Dunlap, Debra; Koeppen, Hartmut; Martin, Scott; Merchant, Mark; Grimmer, Matt; Broccatelli, Fabio; Wang, Jing; Pizzano, Jennifer; Dragovich, Peter S.; Berlin, Michael; Yauch, Robert L. 分享 收藏
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Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors Savill, Kristin M. Zimmerman; Lee, Brian B.; Oeh, Jason; Lin, Jie; Lin, Eva; Chung, Wei-Jen; Young, Amy; Chen, Wennie; Mis, Monika; Mesh, Kathryn; Eastham, Jeffrey; Gnad, Florian; Jiang, Zhaoshi; Stawiski, Eric W.; Haley, Benjamin; Daemen, Anneleen; Wang, Xiaojing; Koeppen, Hartmut; Modrusan, Zora; Martin, Scott E.; Sampath, Deepak; Lin, Kui 分享 收藏
PharmacoDB 2.0: improving scalability and transparency of in vitro pharmacogenomics analysis Feizi, Nikta; Nair, Sisira Kadambat; Smirnov, Petr; Beri, Gangesh; Eeles, Christopher; Esfahani, Parinaz Nasr; Nakano, Minoru; Tkachuk, Denis; Mammoliti, Anthony; Gorobets, Evgeniya; Mer, Arvind Singh; Lin, Eva; Yu, Yihong; Martin, Scott; Hafner, Marc; Haibe-Kains, Benjamin 分享 收藏
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation Ernst, Orna; Sun, Jing; Lin, Bin; Banoth, Balaji; Dorrington, Michael G.; Liang, Jonathan; Schwarz, Benjamin; Stromberg, Kaitlin A.; Katz, Samuel; Vayttaden, Sharat J.; Bradfield, Clinton J.; Slepushkina, Nadia; Rice, Christopher M.; Buehler, Eugen; Khillan, Jaspal S.; McVicar, Daniel W.; Bosio, Catharine M.; Bryant, Clare E.; Sutterwala, Fayyaz S.; Martin, Scott E.; Lal-Nag, Madhu; Fraser, Iain D. C. 分享 收藏
A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein McCormack, Nikki M.; Abera, Mahlet B.; Arnold, Eveline S.; Gibbs, Rebecca M.; Martin, Scott E.; Buehler, Eugen; Chen, Yu-Chi; Chen, Lu; Fischbeck, Kenneth H.; Burnett, Barrington G. 分享 收藏
Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways Pham, Trang H.; Hagenbeek, Thijs J.; Lee, Ho-June; Li, Jason; Rose, Christopher M.; Lin, Eva; Yu, Mamie; Martin, Scott E.; Piskol, Robert; Lacap, Jennifer A.; Sampath, Deepak; Pham, Victoria C.; Modrusan, Zora; Lill, Jennie R.; Klijn, Christiaan; Malek, Shiva; Chang, Matthew T.; Dey, Anwesha 分享 收藏
Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening Shao, Fangyuan; Lyu, Xueying; Miao, Kai; Xie, Lisi; Wang, Haitao; Xiao, Hao; Li, Jie; Chen, Qiang; Ding, Renbo; Chen, Ping; Xing, Fuqiang; Zhang, Xu; Luo, Guang-Hui; Zhu, Wenli; Cheng, Gregory; Lon, Ng Wai; Martin, Scott E.; Wang, Guanyu; Chen, Guokai; Dai, Yunlu; Deng, Chu-Xia 分享 收藏
Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability Kharat, Suhas S.; Ding, Xia; Swaminathan, Divya; Suresh, Akshey; Singh, Manish; Sengodan, Satheesh K.; Burkett, Sandra; Marks, Hanna; Pamala, Chinmayi; He, Yafeng; Fox, Stephen D.; Buehler, Eugen C.; Muegge, Kathrin; Martin, Scott E.; Sharan, Shyam K. 分享 收藏
Linkage of NF-κB pathway and mitosis-related molecules using integrated RNAi screening and transcriptomic analysis of head and neck squamous cell carcinoma Jeon, Jun W.; Saleh, Anthony D.; Cornelius, Shaleeka; Carlson, Sophie; Martin, Scott; Ormanoglu, Pinar; Cheng, Hui; Yang, Xinping; Silvin, Chris; Chen, Zhong; Van Waes, Carter 分享 收藏
CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma Flores, Guillermo; Everett, Joel H.; Boguslawski, Elissa A.; Oswald, Brandon M.; Madaj, Zachary B.; Beddows, Ian; Dikalov, Sergey; Adams, Marie; Klumpp-Thomas, Carleen A.; Kitchen-Goosen, Susan M.; Martin, Scott E.; Caplen, Natasha J.; Helman, Lee J.; Grohar, Patrick J. 分享 收藏
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