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Identification of an antibiotic from an HTS targeting EF-Tu:tRNA interaction: a prospective topical treatment for MRSA skin infections Mandecki, Wlodek; Chudaev, Maxim; Ye, Wenjuan; Wang, Amy Q.; Wilson, Kenneth J.; Xu, Xin; Kim, Jisun; Parker, Dane; Alland, David; Kumar, Pradeep; Li, Barry; Yang, Jason H.; Kreiswirth, Barry; Mediavilla, Jose R.; Marugan, Juan J.; Henderson, Mark J.; Goldman, Emanuel 分享 收藏
Biased Activation of RXFP1 signaling via ML290 Attenuates Experimental Pulmonary Hypertension 通过ML290的偏向性激活RXFP1信号通路可减轻实验性肺动脉高压 Sangam, Shreya; Triantafyllou, Georgios; Pham, Uyen; Troncone, Luca; Yung, Lai-Ming; Chundi, Anand; Darbha, Srikrishna; Gipson, Gregory; Rajesh, Shreyas; Brackin, Riley; Zeghibe, Ana; Shin, Elizabeth; Agoulnik, Irina; Marugan, Juan; Agoulnik, Alexander; Rajagopal, Sudarshan; Yu, Paul 分享 收藏
High- throughput screening for small- molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease 高通量筛选戈谢病和帕金森病中错误折叠葡糖脑苷脂酶小分子稳定剂 Williams, Darian; Glasstetter, Logan M.; Jong, Tiffany T.; Chen, Tiffany; Kapoor, Abhijeet; Zhu, Sha; Zhu, Yanping; Calvo, Raul; Gehrlein, Alexandra; Wong, Kimberly; Hogan, Andrew N.; Vocadlo, David J.; Jagasia, Ravi; Marugan, Juan J.; Sidransky, Ellen; Henderson, Mark J.; Chen, Yu 分享 收藏
Fatty Acid Derivatization and Cyclization of the Immunomodulatory Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor Activity Singh, Sitanshu S.; Calvo, Raul; Kumari, Anju; Sable, Rushikesh V.; Fang, Yuhong; Tao, Dingyin; Hu, Xin; Castle, Sarah Gray; Nahar, Saifun; Li, Dandan; Major, Emily; Sanchez, Tino W.; Kato, Rintaro; Xu, Xin; Zhou, Jian; Liu, Liang; Leclair, Christopher A.; Simeonov, Anton; Baljinnyam, Bolormaa; Henderson, Mark J.; Marugan, Juan; Rudloff, Udo 分享 收藏
Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice Chandia-Cristi, America; Gutierrez, Daniela A.; Dulcey, Andres E.; Lara, Marcelo; Vargas, Lina; Lin, Yi-Han; Jimenez-Munoz, Pablo; Larenas, Gabriela; Xu, Xin; Wang, Amy; Owens, Ashley; Dextras, Christopher; Chen, Yuchi; Pinto, Claudio; Marin, Tamara; Almarza-Salazar, Hugo; Acevedo, Keryma; Cancino, Gonzalo I.; Hu, Xin; Rojas, Patricio; Ferrer, Marc; Southall, Noel; Henderson, Mark J.; Zanlungo, Silvana; Marugan, Juan J.; Alvarez, R. Alejandra 分享 收藏
Increasing the therapeutic vulnerability of heterogenous cell phenotypes within prostate cancer Paxson, Allan I.; Chang, Loren H.; Marr, Kendra D.; Gard, Jaime M.; Nelson, Colin S.; Kapoor, Abhijeet; Harryman, William L.; Marugan, Juan J.; Henderson, Mark J.; Sanchez, Tino W.; Cress, Anne E. 分享 收藏
An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers Sarkar, Rhitajit; Bolel, Priyanka; Kapoor, Abhijeet; Eliseeva, Elena; Dulcey, Andres E.; Templin, Jay S.; Wang, Amy Q.; Xu, Xin; Southall, Noel; Klubo-Gwiezdzinska, Joanna; Neumann, Susanne; Marugan, Juan J.; Gershengorn, Marvin C. 分享 收藏
Using iNSC patient-derived oligodendrocytes to characterize small molecules for globoid-cell leukodystrophy Aditya, Anusha; Lin, Yi-Han; Tao, Dingyin; Hu, Xin; Fang, Yuhong; LeClair, Christopher; Henderson, Mark; Yohannan-Cheria, Ezra; Nandakumar, Renu; Marugan, Juan; Maegawa, Gustavo 分享 收藏
c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration C-abl磷酸化MFN2调节内质网和氧化应激下细胞的线粒体形态，影响细胞存活和神经变性 Martinez, Alexis; Lamaizon, Cristian M.; Valls, Cristian; Llambi, Fabien; Leal, Nancy; Fitzgerald, Patrick; Guy, Cliff; Kaminski, Marcin M.; Inestrosa, Nibaldo C.; van Zundert, Brigitte; Cancino, Gonzalo I.; Dulcey, Andres E.; Zanlungo, Silvana; Marugan, Juan J.; Hetz, Claudio; Green, Douglas R.; Alvarez, Alejandra R. 分享 收藏
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Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators 发现不干扰脂质介质生物合成的15LOX/PEBP1复合物的选择性抗铁性抑制剂 Dar, Haider H.; Ruminska, Karolina Mikulska-; Tyurina, Yulia Y.; Luci, Diane K.; Yasgar, Adam; Samovich, Svetlana N.; Kapralov, Alexander A.; Souryavong, Austin B.; Tyurin, Vladimir A.; Amoscato, Andrew A.; Epperly, Michael W.; V. Shurin, Galina; Standley, Melissa; Holman, Theodore R.; Croix, Claudette M. St.; Watkins, Simon C.; VanDemark, Andrew P.; Rana, Sandeep; V. Zakharov, Alexey; Simeonov, Anton; Marugan, Juan; Mallampalli, Rama K.; Wenzel, Sally E.; Greenberger, Joel S.; Rai, Ganesha; Bayir, Huelya; Bahar, Ivet; Kagan, Valerian E. 分享 收藏
c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer's disease Leon, Rilda; Gutierrez, Daniela A.; Pinto, Claudio; Morales, Cristian; de la Fuente, Catalina; Riquelme, Cristobal; Cortes, Bastian I.; Gonzalez-Martin, Adrian; Chamorro, David; Espinosa, Nelson; Fuentealba, Pablo; Cancino, Gonzalo I.; Zanlungo, Silvana; Dulcey, Andres E.; Marugan, Juan J.; Rojas, Alejandra Alvarez 分享 收藏
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Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2 Esteban-Lopez, Maria; Wilson, Kenneth J.; Myhr, Courtney; Kaftanovskaya, Elena M.; Henderson, Mark J.; Southall, Noel T.; Xu, Xin; Wang, Amy; Hu, Xin; Barnaeva, Elena; Ye, Wenjuan; George, Emmett R.; Sherrill, John T.; Ferrer, Marc; Morello, Roy; Agoulnik, Irina U.; Marugan, Juan J.; Agoulnik, Alexander, I 分享 收藏
Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells Sayedyahossein, Samar; Smith, Jessica; Barnaeva, Elena; Li, Zhigang; Choe, Jun; Ronzetti, Michael; Dextras, Christopher; Hu, Xin; Marugan, Juan; Southall, Noel; Baljinnyam, Bolormaa; Thines, Louise; Tran, Andy D.; Ferrer, Marc; Sacks, David B. 分享 收藏
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