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B

Brian Spencer

neurosciences

56H指数
135论文数
1.9W被引数
收录论文 69
发表时间
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Peptide-Mediated Delivery of α-Synuclein Targeting ASO: Pharmacokinetics, Safety, and CNS Efficacy in a Synucleinopathy Model肽介导的α-突触核蛋白靶向ASO递送：药代动力学、安全性与中枢神经系统疗效在突触核蛋白病模型中的研究
errDrug Metabolism and Disposition
IF4
err2026-04-17
err0
PREAI
errRijwan U. Ahammad; Bao Quach; Sahar Salehi; Robert A. Rissman; Brian Spencer
err分享
err收藏
Retraction Note: Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy撤稿说明：在转基因帕金森综合征小鼠模型中联合应用α-突触核蛋白免疫疗法与抗炎治疗
errActa Neuropathologica Communications
IF5.7
err2026-03-27
err0
errOAAI
errElvira Valera; Brian Spencer; Jerel A. Fields; Ivy Trinh; Anthony Adame; Michael Mante; Edward Rockenstein; Paula Desplats; Eliezer Masliah
err分享
err收藏
Retraction Note: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy撤稿说明：抗α-突触核蛋白免疫疗法可减少α-突触核蛋白在轴突中的传播以及在一种联合病毒载体和转基因模型的突触核蛋白病中的变性。
errActa Neuropathologica Communications
IF5.7
err2026-03-26
err0
errOAAI
errBrian Spencer; Elvira Valera; Edward Rockenstein; Cassia Overk; Michael Mante; Anthony Adame; Wagner Zago; Peter Seubert; Robin Barbour; Dale Schenk; Dora Games; Robert A Rissman; Eliezer Masliah
err分享
err收藏
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy拮抗神经元Toll样受体2通过激活自噬预防synucleinopathy
errCell Reports
IF6.9
err2026-03-11
err0
errOAAI
errChangyoun Kim; Edward Rockenstein; Brian Spencer; Hyung-Koo Kim; Anthony Adame; Margarita Trejo; Klodjan Stafa; He-Jin Lee; Seung-Jae Lee; Eliezer Masliah
err分享
err收藏
A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies一种靶向α-突触核蛋白聚集物的脑内穿梭抗体，用于治疗突触核蛋白病
errnpj Parkinson's Disease
IF0
err2025-08-22
err0
errOAAI
errSungwon An; John J. McInnis; Dongin Kim; Yihang Li; Ozge Tasdemir-Yilmaz; Jinhyung Ahn; Brian C. Mackness; Seung-Hwan Kwon; Julia Maeve Bonner; Miran Yoo; Simon Dujardin; Donghwan Kim; Jinyoung Park; Hyesu Yun; Yi Tang; Laurent Pradier; Sumin Hyeon; Daehae Song; Byungje Sung; Rajaraman Krishnan; Brian Spencer; Robert A. Rissman; Jagdeep K. Sandhu; Arsalan S. Haqqani; Jung-Won Shin; Donghwan B. Kim; Hyeran Lee; Jinwon Jung; Weon-Kyoo You; Alexandra T. Star; Christie E. Delaney; Danica B. Stanimirovic; Sergio Pablo Sardi; Sang Hoon Lee; Can Kayatekin
err分享
err收藏
Neutral pH-Selective Inhibition of Cytosolic Cathepsin B: A Novel Drug Targeting Strategy for Traumatic Brain Injury and Alzheimer’s Disease中性pH选择性抑制细胞质组织蛋白酶B：一种针对创伤性脑损伤和阿尔茨海默病的全新药物靶向策略
errACS Chemical Biology
IF3.8
err2025-07-23
err0
errOAAI
errVivian Hook; Sonia Podvin; Michael C. Yoon; Von V. Phan; Jazmin Florio; Brian Spencer; Charles Mosier; Adeline Cheng; Sarah Ahuett; Jehad Almaliti; William H. Gerwick; Robert A. Rissman; Anthony J. O’Donoghue
err分享
err收藏
Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology人类tau异构体在炎症调节和神经病理发展中的不同作用
errNEUROBIOLOGY OF DISEASE
IF5.6
err2025-07-01
err0
PREAI
errSpencer, Brian; Schueler, Aaron; Sung, Daniel; Rissman, Robert A.
err分享
err收藏
Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK创伤性脑损伤激活脑内细胞质组织蛋白酶B活性，并被中性pH选择性抑制剂探针Z-Arg-Lys-AOMK抑制
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2025-03-25
err0
errOAAI
errPodvin, S; Florio, J; Spencer, B; Mante, M; Guzman, E; Arias, C; Mosier, C; Phan, V; Yoon, MC; Almaliti, J; O'Donoghue, AJ; Gerwick, WH; Rissman, RA; Hook, V
err分享
err收藏
RETRACTION: Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD撤稿：利用慢病毒介导的神经丝蛋白递送促进了野生型α-突触核蛋白的清除，并减少了α-突触核蛋白路易体痴呆模型中的病理变化。
errMOLECULAR THERAPY
IF12
err2025-02-01
err0
PREAI
errSpencer, Brian; Michael, Sarah; Shen, Jay; Kosberg, Kori; Rockenstein, Edward; Patrick, Christina; Adame, Anthony; Masliah, Eliezer
err分享
err收藏
RETRACTION: ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo撤回：ESCRT介导的靶向大脑α-synuclein单链抗体的摄取与降解可减轻体内神经元退变
errMOLECULAR THERAPY
IF12
err2025-02-01
err0
errOAAI
errSpencer, Brian; Emadi, Sharareh; Desplats, Paula; Eleuteri, Simona; Michael, Sarah; Kosberg, Kori; Shen, Jay; Rockenstein, Edward; Patrick, Christina; Adame, Anthony; Gonzalez, Tania; Sierks, Michael; Masliah, Eliezer
err分享
err收藏
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models (vol 5, 46, 2014)
errSTEM CELL RESEARCH & THERAPY
IF7.3
err2024-03-25
err0
errOAAI
errBlurton-Jones, Mathew; Spencer, Brian; Michael, Sara; Castello, Nicholas A.; Agazaryan, Andranik A.; Davis, Joy L.; Mueller, Franz-Josef; Loring, Jeanne F.; Masliah, Eliezer; Laferla, Frank M.
err分享
err收藏
Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy Body Disease(vol127, pg163, 2019)
errNEUROBIOLOGY OF DISEASE
IF5.6
err2024-02-01
err0
errOAAI
errSpencer, Brian; Trinh, Ivy; Rockenstein, Edward; Mante, Michael; Florio, Jazmin; Adame, Anthony; El-Agnaf, Omar M. A.; Kim, Changyoun; Masliah, Eliezer; Rissman, Robert A.
err分享
err收藏
Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease
errNEUROBIOLOGY OF DISEASE
IF5.6
err2023-10-01
err3
errOAAI
errLeitao, Andre D. G.; Ahammad, Rijwan U.; Spencer, Brian; Wu, Chengbiao; Masliah, Eliezer; Rissman, Robert A.
err分享
err收藏
Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer's Disease Mice
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2023-07-25
err0
errOAAI
errLeitao, Andre D. G.; Spencer, Brian; Sarsoza, Floyd; Ngolab, Jennifer; Amalraj, Jessica; Masliah, Eliezer; Wu, Chengbiao; Rissman, Robert A.
err分享
err收藏
Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy
errNEUROBIOLOGY OF DISEASE
IF5.6
err2023-03-01
err4
errOAAI
errLin, Suzhen; Leitao, Andre D. G.; Fang, Savannah; Gu, Yingli; Barber, Sophia; Gilliard-Telefoni, Rhiannon; Castro, Alfredo; Sung, Kijung; Shen, Ruinan; Florio, Jazmin B.; Mante, Michael L.; Ding, Jianqing; Spencer, Brian; Masliah, Eliezer; Rissman, Robert A.; Wu, Chengbiao
err分享
err收藏
D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2023-02-07
err2
PREAI
errDutta, Aloke K.; Armstrong, Christopher; Luo, Dan; Das, Banibrata; Spencer, Brian; Rissman, Robert A.
err分享
err收藏
Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein (vol 85, pg 76, 2015)
errNEURON
IF15
err2023-01-01
err3
errOAAI
errDhungel, Nripesh; Eleuteri, Simona; Li, Ling-bo; Kramer, Nicholas J.; Chartron, Justin W.; Spencer, Brian; Kosberg, Kori; Fields, Jerel Adam; Stafa, Klodjan; Adame, Anthony; Lashuel, Hilal; Frydman, Judith; Shen, Kang; Masliah, Eliezer; Gitler, Aaron D.
err分享
err收藏
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2021-03-02
err49
errOAAI
errRynearson, Kevin D.; Ponnusamy, Moorthi; Prikhodko, Olga; Xie, Yuhuan; Zhang, Can; Nguyen, Phuong; Hug, Brenda; Sawa, Mariko; Becker, Ann; Spencer, Brian; Florio, Jazmin; Mante, Michael; Salehi, Bahar; Arias, Carlos; Galasko, Douglas; Head, Brian P.; Johnson, Graham; Lin, Jiunn H.; Duddy, Steven K.; Rissman, Robert A.; Mobley, William C.; Thinakaran, Gopal; Tanzi, Rudolph E.; Wagner, Steven L.
err分享
err收藏
Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
errEXPERIMENTAL AND MOLECULAR MEDICINE
IF12.9
err2021-02-16
err25
errOAAI
errKim, Changyoun; Kwon, Somin; Iba, Michiyo; Spencer, Brian; Rockenstein, Edward; Mante, Michael; Adame, Anthony; Shin, Soo Jean; Fields, Jerel A.; Rissman, Robert A.; Lee, Seung-Jae; Masliah, Eliezer
err分享
err收藏
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease
errTRANSLATIONAL NEURODEGENERATION
IF15.2
err2020-06-18
err45
errOAAI
errShen, Ruinan; Zhao, Xiaobei; He, Lu; Ding, Yongbo; Xu, Wei; Lin, Suzhen; Fang, Savannah; Yang, Wanlin; Sung, Kijung; Spencer, Brian; Rissman, Robert A.; Lei, Ming; Ding, Jianqing; Wu, Chengbiao
err分享
err收藏

研究方向

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合作学者
合作期刊
E
Eliezer Masliah
H 指数: 195 · 论文数: 1.2K
A
Anders M. Dale
H 指数: 185 · 论文数: 1.2K
G
Georg Schett
H 指数: 154 · 论文数: 1.7K
I
Inder M. Verma
H 指数: 153 · 论文数: 571
R
Rudolph E. Tanzi
H 指数: 143 · 论文数: 836
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