Jon L. Collins - Publications, H-index & Citations

Jon L. Collins

university of north carolina at chapel hill

48H指数

105论文数

1.3W被引数

收录论文 53

发表时间

Toward a Small Molecule Therapy for Angelman Syndrome: Structure–Activity Relationship Studies of 3-Aminopyrazole Phenylacetamides as Paternal Ube3a Unsilencers 朝向Angelman综合征的小分子疗法：3-氨基吡唑苯乙酸酰胺作为父源Ube3a去沉默剂的构效关系研究

Journal of Medicinal Chemistry

IF6.8

2026-05-08

PREAI

Anna Welton-Arndt; Hannah C. Nourie; Hanna Vihma; Siyuan Liang; Jonathan Super; Kelin Li; Jon L. Collins; Hsueh-Cheng Huang; Allison Zhang; Ashley E. Trojniak; Benjamin D. Philpot; Jeffrey Aubé

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 NSD2降解的结构基础：通过靶向招募SCF-FBXO22

Nature Communications

IF15.7

2026-04-23

OAAI

Kevin C. Robertson; Sascha J. Amann; Tongkun Liu; Adam V. Funk; Xianxi Wang; Irina Grishkovskaya; Aamir Mehmood; John R. Tabor; Jacqueline L. Norris-Drouin; Cheryl H. Arrowsmith; Jon L. Collins; Yinglong Miao; Michael J. Emanuele; David Haselbach; Lindsey I. James; Nicholas G. Brown

Molecular Determinants of Affinity and Isoform Selectivity in Protein-Small Molecule Hybrid Inhibitors of Carbonic Anhydrase

BIOCONJUGATE CHEMISTRY

IF3.9

2025-03-01

PREAI

Torres, Sarah W.; Lan, Crystal; Harthorn, Abbigael; Schmitz, Zachary; Blanchard, Paul L.; Collins, Jon; Hackel, Benjamin J.

Ube3a unsilencer for the potential treatment of Angelman syndrome

NATURE COMMUNICATIONS

IF15.7

2024-07-08

OAAI

Vihma, Hanna; Li, Kelin; Welton-Arndt, Anna; Smith, Audrey L.; Bettadapur, Kiran R.; Gilmore, Rachel B.; Gao, Eric; Cotney, Justin L.; Huang, Hsueh-Cheng; Collins, Jon L.; Chamberlain, Stormy J.; Lee, Hyeong-Min; Aube, Jeffrey; Philpot, Benjamin D.

Recruitment of FBXO22 for targeted degradation of NSD2 招募FBXO22靶向降解NSD2

NATURE CHEMICAL BIOLOGY

IF13.7

2024-07-04

PREAI

Nie, David Y.; Tabor, John R.; Li, Jianping; Kutera, Maria; St-Germain, Jonathan; Hanley, Ronan P.; Wolf, Esther; Paulakonis, Ethan; Kenney, Tristan M. G.; Duan, Shili; Shrestha, Suman; Owens, Dominic D. G.; Maitland, Matthew E. R.; Pon, Ailing; Szewczyk, Magdalena; Lamberto, Anthony Joseph; Menes, Michael; Li, Fengling; Penn, Linda Z.; Barsyte-Lovejoy, Dalia; Brown, Nicholas G.; Barsotti, Anthony M.; Stamford, Andrew W.; Collins, Jon L.; Wilson, Derek J.; Raught, Brian; Licht, Jonathan D.; James, Lindsey I.; Arrowsmith, Cheryl H.

Autoregulation of the human liver X receptor α promoter

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

315

OAAI

Laffitte, BA; Joseph, SB; Walczak, R; Pei, LM; Wilpitz, DC; Collins, JL; Tontonoz, P

Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes

CELL CHEMICAL BIOLOGY

IF7.2

2019-11-01

OAAI

Beliveau, Francois; Tarkar, Aarti; Dion, Sebastien P.; Desilets, Antoine; Ghinet, Mariana Gabriela; Boudreault, Pierre-Luc; St-Georges, Catherine; Marsault, Eric; Paone, Daniel; Collins, Jon; Macphee, Colin H.; Campobasso, Nino; Groy, Arthur; Cottom, Josh; Ouellette, Michael; Pope, Andrew J.; Leduc, Richard

Enzymatic- and Iridium-Catalyzed Asymmetric Synthesis of a Benzothiazepinylphosphonate Bile Acid Transporter Inhibitor

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2013-12-04

PREAI

Cowan, David J.; Collins, Jon L.; Mitchell, Mark B.; Ray, John A.; Sutton, Peter W.; Sarjeant, Amy A.; Boros, Eric E.

Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-06-06

114

PREAI

Wu, Yulin; Aquino, Christopher J.; Cowan, David J.; Anderson, Don L.; Ambroso, Jeff L.; Bishop, Michael J.; Boros, Eric E.; Chen, Lihong; Cunningham, Alan; Dobbins, Robert L.; Feldman, Paul L.; Harston, Lindsey T.; Kaldor, Istvan W.; Klein, Ryan; Liang, Xi; McIntyre, Maggie S.; Merrill, Christine L.; Patterson, Kristin M.; Prescott, Judith S.; Ray, John S.; Roller, Shane G.; Yao, Xiaozhou; Young, Andrew; Yuen, Josephine; Collins, Jon L.

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2010-10-01

180

OAAI

Donkin, James J.; Stukas, Sophie; Hirsch-Reinshagen, Veronica; Namjoshi, Dhananjay; Wilkinson, Anna; May, Sharon; Chan, Jeniffer; Fan, Jianjia; Collins, Jon; Wellington, Cheryl L.

GSK4112, a Small Molecule Chemical Probe for the Cell Biology of the Nuclear Heme Receptor Rev-erbα

ACS CHEMICAL BIOLOGY

IF3.8

2010-08-13

133

PREAI

Grant, Daniel; Yin, Lei; Collins, Jon L.; Parks, Derek J.; Orband-Miller, Lisa A.; Wisely, G. Bruce; Joshi, Shree; Lazar, Mitchell A.; Willson, Timothy M.; Zuercher, William J.

Cholestyramine Reverses Hyperglycemia and Enhances Glucose-Stimulated Glucagon-Like Peptide 1 Release in Zucker Diabetic Fatty Rats

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2010-07-01

PREAI

Chen, Lihong; McNulty, Judi; Anderson, Don; Liu, Yaping; Nystrom, Christopher; Bullard, Sarah; Collins, Jon; Handlon, Anthony L.; Klein, Ryan; Grimes, Angela; Murray, David; Brown, Roger; Krull, David; Benson, Bill; Kleymenova, Elena; Remlinger, Katja; Young, Andrew; Yao, Xiaozhou

Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-03-26

PREAI

Zuercher, William J.; Buckholz, Richard G.; Campobasso, Nino; Collins, Jon L.; Galardi, Cristin M.; Gampe, Robert T.; Hyatt, Stephen M.; Merrihew, Susan L.; Moore, John T.; Oplinger, Jeffrey A.; Reid, Paul R.; Spearing, Paul K.; Stanley, Thomas B.; Stewart, Eugene L.; Willson, Timothy M.

The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro

DIABETOLOGIA

IF10.2

2009-05-05

OAAI

Scholz, H.; Lund, T.; Dahle, M. K.; Collins, J. L.; Korsgren, O.; Wang, J. E.; Foss, A.

Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner

JOURNAL OF CELL SCIENCE

IF3.6

2008-11-01

120

OAAI

Meng, Qing Jun; McMaster, Andrew; Beesley, Stephen; Lu, Wei Qun; Gibbs, Julie; Parks, Derek; Collins, Jon; Farrow, Stuart; Donn, Rachelle; Ray, David; Loudon, Andrew

Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth

JOURNAL OF IMMUNOLOGY

IF3.4

2008-09-15

OAAI

Birrell, Mark A.; De Alba, Jorge; Catley, Matthew C.; Hardaker, Elizabeth; Wong, Sissie; Collins, Michael; Clarke, Deborah L.; Farrow, Stuart N.; Willson, Timothy M.; Collins, Jon L.; Belvisi, Maria G.

Structure-guided design of N-phenyl tertiary Amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-08-23

PREAI

Chao, Esther Y.; Caravella, Justin A.; Watson, Mike A.; Campobasso, Nino; Ghisletti, Serena; Billin, Andrew N.; Galardi, Cristin; Wang, Ping; Laffitte, Bryan A.; Lannone, Marie A.; Goodwin, Bryan J.; Nichols, Jason A.; Parks, Derek J.; Stewart, Eugene; Wiethe, Robert W.; Williams, Shawn P.; Smallwood, Angela; Pearce, Kenneth H.; Glass, Christopher K.; Willson, Timothy M.; Zuercher, William J.; Collins, Jon L.

ApoE promotes the proteolytic degradation of Aβ

NEURON

IF15

2008-06-01

868

OAAI

Jiang, Qingguang; Lee, C. Y. Daniel; Mandrekar, Shweta; Wilkinson, Brandy; Cramer, Paige; Zelcer, Noam; Mann, Karen; Lamb, Bruce; Willson, Timothy M.; Collins, Jon L.; Richardson, Jill C.; Smith, Jonathan D.; Comery, Thomas A.; Riddell, David; Holtzman, David M.; Tontonoz, Peter; Landreth, Gary E.

Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-11-01

OAAI

Birrell, Mark A.; Catley, Matthew C.; Hardaker, Elizabeth; Wong, Sissie; Willson, Timothy M.; McCluskie, Kerryn; Leonard, Thomas; Farrow, Stuart N.; Collins, Jon L.; Haj-Yahia, Saleem; Belvisi, Maria G.

Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2007-03-01

131

OAAI

Xue, Yu; Chao, Esther; Zuercher, William J.; Willson, Timothy M.; Collins, Jon L.; Redinbo, Matthew R.

研究方向