Cayetano Pleguezuelos‐Manzano

Hubrecht Institute and UMC Utrecht

14H指数

30论文数

2.7K被引数

收录论文 15

发表时间

Discovery of a secreted Bacteroides fragilis mucinase that cleaves mucins with bis-T O-glycans through a carbohydrate binding module-dependent mechanism 发现一种分泌型的脆弱拟杆菌（Bacteroides fragilis）黏蛋白酶，该酶通过碳水化合物结合模块依赖性机制裂解含双-T O-糖苷键的黏蛋白。

Gut Microbes

IF11

2026-03-19

OAAI

Yoshiki Narimatsu; Cayetano Pleguezuelos-Manzano; Daniel Hornikx; Felix Goerdeler; Thapakorn Jaroentomeechai; Katia Flores; Sanae Narimatsu; Charelle Boot; Lars Hansen; Fabien Durbesson; Renaud Vincentelli; Laurie Comstock; Hans Clevers; Victor Taleb; Francisco Corzana; Bernard Henrissat; Henrik Clausen; Ramon Hurtado-Guerrero; Christian Büll

Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells 基因表达谱分析显示，与类器官和Transwells相比，人诱导多能干细胞（hiPSC）来源的肠道芯片在营养和药物代谢方面有所增强，且成熟度更高。

Stem Cell Reports

IF5.1

2025-11-13

OAAI

Renée Moerkens; Joram Mooiweer; Eline Smits; Marijn Berg; Aarón D. Ramírez-Sánchez; Rutger Modderman; Jens Puschhof; Cayetano Pleguezuelos-Manzano; Robert J. Barrett; Cisca Wijmenga; Iris H. Jonkers; Sebo Withoff

Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids 铜绿假单胞菌和人2D上呼吸道类器官共培养模型的双重RNA测序

SCIENTIFIC REPORTS

IF3.9

2025-01-17

OAAI

Pleguezuelos-Manzano, Cayetano; Beenker, Wouter A. G.; van Son, Gijs J. F.; Begthel, Harry; Amatngalim, Gimano D.; Beekman, Jeffrey M.; Clevers, Hans; den Hertog, Jeroen

Standardizing designed and emergent quantitative features in microphysiological systems

NATURE BIOMEDICAL ENGINEERING

IF26.6

2024-08-26

PREAI

Nahon, Dennis M.; Moerkens, Renee; Aydogmus, Hande; Lendemeijer, Bas; Martinez-Silgado, Adriana; Stein, Jeroen M.; Dostanic, Milica; Frimat, Jean-Philippe; Gontan, Cristina; de Graaf, Mees N. S.; Hu, Michel; Kasi, Dhanesh G.; Koch, Lena S.; Le, Kieu T. T.; Lim, Sangho; Middelkamp, Heleen H. T.; Mooiweer, Joram; Motreuil-Ragot, Paul; Niggl, Eva; Pleguezuelos-Manzano, Cayetano; Puschhof, Jens; Revyn, Nele; Rivera-Arbelaez, Jose M.; Slager, Jelle; Windt, Laura M.; Zakharova, Mariia; van Meer, Berend J.; Orlova, Valeria V.; de Vrij, Femke M. S.; Withoff, Sebo; Mastrangeli, Massimo; van der Meer, Andries D.; Mummery, Christine L.

Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox 使用PTA分析工具箱以核苷酸分辨率进行全面的单细胞基因组分析

CELL GENOMICS

IF9

2023-09-01

OAAI

Middelkamp, Sjors; Manders, Freek; Peci, Flavia; Roosmalen, Markus J. van; Gonzalez, Diego Montiel; Bertrums, Eline J. M.; Werf, Inge van der; Derks, Lucca L. M.; Groenen, Niels M.; Verheul, Mark; Trabut, Laurianne; Pleguezuelos-Manzano, Cayetano; Brandsma, Arianne M.; Antoniou, Evangelia; Reinhardt, Dirk; Bierings, Marc; Belderbos, Mirjam E.; van Boxtel, Ruben

Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs (vol 13, 3516, 2023)

SCIENTIFIC REPORTS

IF3.9

2023-06-21

OAAI

Casellas, Carla Pou; Pleguezuelos-Manzano, Cayetano; Rookmaaker, Maarten B.; Verhaar, Marianne C.; Clevers, Hans

Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs

SCIENTIFIC REPORTS

IF3.9

2023-03-02

OAAI

Casellas, Carla Pou; Pleguezuelos-Manzano, Cayetano; Rookmaaker, Maarten B.; Verhaar, Marianne C.; Clevers, Hans

DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

CELL DEATH DISCOVERY

IF7

2023-01-21

OAAI

Juan, Lucia San; Freije, Ana; Sanz-Gomez, Natalia; Jimenez-Matias, Beatriz; Pleguezuelos-Manzano, Cayetano; Sanz, J. Ramon; de Diego, Ernesto; Naranjo, Sara; Clevers, Hans; Gandarillas, Alberto

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene 产肠毒素的脆弱拟杆菌 (ETBF) 定殖的小鼠中的结肠肿瘤不显示独特的突变特征，而是在APC基因中具有宿主依赖性的改变

MICROBIOLOGY SPECTRUM

IF3.8

2022-06-29

OAAI

Allen, Jawara; Huber, Axel Rosendahl; Pleguezuelos-Manzano, Cayetano; Puschhof, Jens; Wu, Shaoguang; Wu, Xinqun; Boot, Charelle; Saftien, Aurelia; O'Hagan, Heather M.; Wang, Hao; van Boxtel, Ruben; Clevers, Hans; Sears, Cynthia L.

A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

NATURE COMMUNICATIONS

IF15.7

2021-09-17

OAAI

Beumer, Joep; Geurts, Maarten H.; Lamers, Mart M.; Puschhof, Jens; Zhang, Jingshu; van der Vaart, Jelte; Mykytyn, Anna Z.; Breugem, Tim, I; Riesebosch, Samra; Schipper, Debby; van den Doel, Petra B.; de Lau, Wim; Pleguezuelos-Manzano, Cayetano; Busslinger, Georg; Haagmans, Bart L.; Clevers, Hans

Intestinal organoid cocultures with microbes

NATURE PROTOCOLS

IF16

2021-08-11

129

OAAI

Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Martinez-Silgado, Adriana; Akkerman, Ninouk; Saftien, Aurelia; Boot, Charelle; de Waal, Amy; Beumer, Joep; Dutta, Devanjali; Heo, Inha; Clevers, Hans

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

LIFE SCIENCE ALLIANCE

IF2.9

2021-08-09

OAAI

Geurts, Maarten H.; de Poel, Eyleen; Pleguezuelos-Manzano, Cayetano; Oka, Rurika; Carrillo, Leo; Andersson-Rolf, Amanda; Boretto, Matteo; Brunsveld, Jesse E.; van Boxtel, Ruben; Beekman, Jeffrey M.; Clevers, Hans

A bacterial mutational footprint in colorectal cancer genomes

BRITISH JOURNAL OF CANCER

IF6.8

2021-03-19

OAAI

Rosendahl Huber, Axel; Pleguezuelos-Manzano, Cayetano; Puschhof, Jens

Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development

CANCER CELL INTERNATIONAL

IF6

2020-12-03

OAAI

Adam, Ronja S.; van Neerven, Sanne M.; Pleguezuelos-Manzano, Cayetano; Simmini, Salvatore; Leveille, Nicolas; de Groot, Nina E.; Holding, Andrew N.; Markowetz, Florian; Vermeulen, Louis

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

CELL STEM CELL

IF20.4

2020-11-01

OAAI

Miao, Yi; Ha, Andrew; de Lau, Wim; Yuki, Kanako; Santos, Antonio J. M.; You, Changjiang; Geurts, Maarten H.; Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Peng, Weng Chuan; Senlice, Ramazan; Piani, Carol; Buikema, Jan W.; Gbenedio, Oghenekevwe M.; Vallon, Mario; Yuan, Jenny; de Haan, Sanne; Hemrika, Wieger; Rosch, Kathrin; Dang, Luke T.; Baker, David; Ott, Melanie; Depeille, Philippe; Wu, Sean M.; Drost, Jarno; Nusse, Roeland; Roose, Jeroen P.; Piehler, Jacob; Boj, Sylvia F.; Janda, Claudia Y.; Clevers, Hans; Kuo, Calvin J.; Garcia, K. Christopher

研究方向