.png){kind=icon}
返回
Standardizing designed and emergent quantitative features in microphysiological systems
.png){kind=icon}
PRE
AI
DOI：10.1038/s41551-024-01236-0.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide physiological mechanical cues to cells, include fluid flow and can be interlinked (hence, they are often referred to as microfluidic tissue chips or organs-on-chips). Here, by means of examples of MPSs of the vascular system, intestine, brain and heart, we advocate for the development of standards that allow for comparisons of quantitative physiological features in MPSs and humans. Such standards should ensure that the in vivo relevance and predictive value of MPSs can be properly assessed as fit-for-purpose in specific applications, such as the assessment of drug toxicity, the identification of therapeutics or the understanding of human physiology or disease. Specifically, we distinguish designed features, which can be controlled via the design of the MPS, from emergent features, which describe cellular function, and propose methods for improving MPSs with readouts and sensors for the quantitative monitoring of complex physiology towards enabling wider end-user adoption and regulatory acceptance. This Perspective discusses the need for standards that allow for comparisons of quantitative physiological features in microphysiological systems and humans.
Keyword:
ON-A-CHIP
BLOOD-BRAIN-BARRIER
IN-VITRO
IMPEDANCE SPECTROSCOPY
MICROFLUIDIC PLATFORM
THERMOPLASTIC ELASTOMER
INTESTINAL VILLI
HIGH-THROUGHPUT
CELL-MIGRATION
MODEL
期刊
IF:
26.6
论文数:
1.7K
被引数:
2.0W
机构
引用论文
Sensitivity-Enhanced Fluidic Glucose Sensor Based on a Microwave Resonator Coupled With an Interferometric System for Noninvasive and Continuous Detection基于微波谐振器的灵敏度增强的流体葡萄糖传感器与干涉测量系统耦合，用于无创和连续检测
PREAI
分享收藏A Vascular Endothelial Growth Factor-Dependent Sprouting Angiogenesis Assay Based on an In Vitro Human Blood Vessel Model for the Study of Anti-Angiogenic Drugs基于体外人血管模型的血管内皮生长因子依赖的发芽血管生成试验，用于抗血管生成药物的研究.png)
EBIOMEDICINE
OAAI
EBIOMEDICINEIF10.8
OAAI分享收藏Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology使用来自离体MRI和组织学的计算图谱表征衰老和阿尔茨海默氏病中的人海马OAAI
OAAI分享收藏
查看更多内容