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J

Jessica B. Spinelli

University of Massachusetts Chan Medical School
H指数:22
被引数:5,267

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The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations

GENEVA平台模拟肿瘤嵌合体，以揭示对KRAS抑制剂的反应差异并识别更优的药物组合

Nature Cancer
IF28.5
2026-02-240
OAAI
Johnny X. Yu; Jung Min Suh; Katerina D. Popova; Kristle Garcia; Tanvi Joshi; Bruce Culbertson; Jessica B. Spinelli; Vishvak Subramanyam; Kevin Lou; Trey Charbonneau; Kevan M. Shokat; Jonathan Weissman; Hani Goodarzi
Distinct S-adenosylmethionine synthases link phosphatidylcholine to mitochondrial function and stress survival

特定的S-腺苷甲硫氨酸合成酶将磷脂酰胆碱与线粒体功能及应激生存联系起来

PLOS BIOLOGY
IF7.2
2025-12-010
PRE
Munden, Athena L.; Mushtaq, Arjamand; Lui, Dominique S.; Edwards, Katherine M.; Higgins, Daniel P.; Biswas, Kasturi; Walker, Rachel M.; Crowley, Leah H.; Fanelli, Matthew J.; Ngyuen, Thien-Kim; Ericsson, Maria; Godbole, Adwait A.; Haley, John A.; Lewis, Caroline A.; Spinelli, Jessica B.; Harrison, Benjamin; Raftery, Daniel; Djukovic, Danijel; Promislow, Daniel E. L.; Miller, Dana L.; Walker, Amy K.
Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation

再生的肝脏利用氨来支持从头嘧啶合成和细胞增殖

Nature Communications
IF15.7
2025-11-040
OAAI
Berwini B. Endaya; Lukáš Kučera; Dan-Diem Thi Le; Jessica B. Spinelli; Andrea Brožková; Dominika Luptáková; Kryštof Klíma; Gabriela L. Oliveira; Petra Brisudová; Klára Boháčová; Štěpána Boukalová; Renata Zobalová; František Kolář; Karel Chalupsky; Klára Dohnalová; Arash Yarmohammadi-Barzegar; Šárka Dvořáková; Evgeniya Biryukova; Marta Kaliaeva; Vladimír Havlíček; Radislav Sedláček; Jan Procházka; Libor Vítek; Sunghyouk Park; Pavel Martásek; Zdeněk Krška; Paulo J. Oliveira; Michael V. Berridge; Jiří Neužil
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

谷胱甘肽硫转移酶通过直接激活MPST来调控线粒体功能和运动表现。

CELL METABOLISM
IF30.9
2025-02-010
PRE
Sprenger, Hans-Georg; Mittenbuhler, Melanie J.; Sun, Yizhi; Van Vranken, Jonathan G.; Schindler, Sebastian; Jayaraj, Abhilash; Khetarpal, Sumeet A.; Smythers, Amanda L.; Vargas-Castillo, Ariana; Puszynska, Anna M.; Spinelli, Jessica B.; Armani, Andrea; Kunchok, Tenzin; Ryback, Birgitta; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; O'Young, Coby; Braithwaite, Chelsea; Dhe-Paganon, Sirano; Burger, Nils; Mills, Evanna L.; Gygi, Steven P.; Paulo, Joao A.; Arthanari, Haribabu; Chouchani, Edward T.; Sabatini, David M.; Spiegelman, Bruce M.
Rhodoquinone carries electrons in the mammalian electron transport chain

罗多醌在哺乳动物电子传递链中携带电子。

CELL
IF42.5
2025-02-011
OAAI
Valeros, Jonathan; Jerome, Madison; Tseyang, Tenzin; Vo, Paula; Do, Thang; Palomino, Diana Fajardo; Grotehans, Nils; Kunala, Manisha; Jerrett, Alexandra E.; Hathiramani, Nicolai R.; Mireku, Michael; Magesh, Rayna Y.; Yenilmez, Batuhan; Rosen, Paul C.; Mann, Jessica L.; Myers, Jacob W.; Kunchok, Tenzin; Manning, Tanner L.; Boercker, Lily N.; Carr, Paige E.; Bin Munim, Muhammad; Lewis, Caroline A.; Sabatini, David M.; Kelly, Mark; Xie, Jun; Czech, Michael P.; Gao, Guangping; Shepherd, Jennifer N.; Walker, Amy K.; Kim, Hahn; V. Watson, Emma; Spinelli, Jessica B.
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress
NATURE METABOLISM
IF20.8
2024-10-140
PRE
Korobkina, Ekaterina D.; Calejman, Camila Martinez; Haley, John A.; Kelly, Miranda E.; Li, Huawei; Gaughan, Maria; Chen, Qingbo; Pepper, Hannah L.; Ahmad, Hafsah; Boucher, Alexander; Fluharty, Shelagh M.; Lin, Te-Yueh; Lotun, Anoushka; Peura, Jessica; Trefely, Sophie; Green, Courtney R.; Vo, Paula; Semenkovich, Clay F.; Pitarresi, Jason R.; Spinelli, Jessica B.; Aydemir, Ozkan; Metallo, Christian M.; Lynes, Matthew D.; Jang, Cholsoon; Snyder, Nathaniel W.; Wellen, Kathryn E.; Guertin, David A.
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis

核苷酸生物合成的破坏重新编程线粒体代谢以抑制脂肪生成

JOURNAL OF LIPID RESEARCH
IF4.1
2024-10-010
OAAI
Pinette, Julia A.; Myers, Jacob W.; Park, Woo Yong; Bryant, Heather G.; Eddie, Alex M.; Wilson, Genesis A.; Montufar, Claudia; Shaikh, Zayedali; Vue, Zer; Nunn, Elizabeth R.; Bessho, Ryoichi; Cottam, Matthew A.; Haase, Volker H.; Hinton, Antentor O.; Spinelli, Jessica B.; Cartailler, Jean-Philippe; Zaganjor, Elma
MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
SCIENCE ADVANCES
IF12.5
2024-01-191
OAAI
Santamans, Ayelen M.; Cicuendez, Beatriz; Mora, Alfonso; Villalba-Orero, Maria; Rajlic, Sanela; Crespo, Maria; Vo, Paula; Jerome, Madison; Macias, Alvaro; Lopez, Juan Antonio; Leiva, Magdalena; Rocha, Susana F.; Leon, Marta; Rodriguez, Elena; Leiva, Luis; Chocano, Aranzazu Pintor; Lunar, Ines Garcia; Garcia-Alvarez, Ana; Hernansanz-Agustin, Pablo; Peinado, Victor I.; Barbera, Joan Albert; Ibanez, Borja; Vazquez, Jesus; Spinelli, Jessica B.; Daiber, Andreas; Oliver, Eduardo; Sabio, Guadalupe
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

胰岛素受体的动态聚集是其信号传导的基础，并在胰岛素抵抗中被破坏

NATURE COMMUNICATIONS
IF15.7
2022-12-0619
OAAI
Dall'Agnese, Alessandra; Platt, Jesse M.; Zheng, Ming M.; Friesen, Max; Dall'Agnese, Giuseppe; Blaise, Alyssa M.; Spinelli, Jessica B.; Henninger, Jonathan E.; Tevonian, Erin N.; Hannett, Nancy M.; Lazaris, Charalampos; Drescher, Hannah K.; Bartsch, Lea M.; Kilgore, Henry R.; Jaenisch, Rudolf; Griffith, Linda G.; Cisse, Ibrahim I.; Jeppesen, Jacob F.; Lee, Tong I.; Young, Richard A.

研究方向

暂未获取到该数据
M
Marcia C. Haigis
H 指数:75论文数:294被引数:3.4万
E
Elma Zaganjor
H 指数:24论文数:50被引数:5,870
P
Paula Vo
H 指数:5论文数:14被引数:87
D
David A. Guertin
H 指数:43论文数:91被引数:2.7万
M
Madison Jerome
H 指数:5论文数:19被引数:63
J
Jacob W. Myers
H 指数:3论文数:6被引数:43
D
David M. Sabatini
H 指数:149论文数:539被引数:15.4万
C
Cholsoon Jang
H 指数:52论文数:215被引数:1.4万
S
Steven P. Gygi
H 指数:195论文数:1,033被引数:17.0万
T
Tenzin Kunchok
H 指数:18论文数:57被引数:2,605