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Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response 通过eIF2γ 募集底物可增强全磷酸酶的催化效率，从而终止整合的应激反应 Yan, Yahui; Shetty, Maithili; Harding, Heather P.; George, Ginto; Zyryanova, Alisa; Labbe, Katherine; Mafi, Amirhossein; Hao, Qi; Sidrauski, Carmela; Ron, David; Hinnebusch, Alan 分享 收藏
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Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response Jiang, HY; Wek, SA; McGrath, BC; Lu, D; Hai, TW; Harding, HP; Wang, XZ; Ron, D; Cavener, DR; Wek, RC 分享 收藏
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Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress Blais, Jaime D.; Addison, Christina L.; Edge, Robert; Falls, Theresa; Zhao, Huijun; Wary, Kishore; Koumenis, Costas; Harding, Heather P.; Ron, David; Holcik, Martin; Bell, John C. 分享 收藏
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Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP Perera, Luke A.; Hattersley, Andrew T.; Harding, Heather P.; Wakeling, Matthew N.; Flanagan, Sarah E.; Mohsina, Ibrahim; Raza, Jamal; Gardham, Alice; Ron, David; De Franco, Elisa 分享 收藏
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ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B Zyryanova, Alisa F.; Kashiwagi, Kazuhiro; Rato, Claudia; Harding, Heather P.; Crespillo-Casado, Ana; Perera, Luke A.; Sakamoto, Ayako; Nishimoto, Madoka; Yonemochi, Mayumi; Shirouzu, Mikako; Ito, Takuhiro; Ron, David 分享 收藏
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GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans GDF15提供小鼠和人类营养应激的内分泌信号 Patel, Satish; Alvarez-Guaita, Anna; Melvin, Audrey; Rimmington, Debra; Dattilo, Alessia; Miedzybrodzka, Emily L.; Cimino, Irene; Maurin, Anne-Catherine; Roberts, Geoffrey P.; Meek, Claire L.; Virtue, Samuel; Sparks, Lauren M.; Parsons, Stephanie A.; Redman, Leanne M.; Bray, George A.; Liou, Alice P.; Woods, Rachel M.; Parry, Sion A.; Jeppesen, Per B.; Kolnes, Anders J.; Harding, Heather P.; Ron, David; Vidal-Puig, Antonio; Reimann, Frank; Gribble, Fiona M.; Hulston, Carl J.; Farooqi, I. Sadaf; Fafournoux, Pierre; Smith, Steven R.; Jensen, Jorgen; Breen, Danna; Wu, Zhidan; Zhang, Bei B.; Coll, Anthony P.; Savage, David B.; O'Rahilly, Stephen 分享 收藏
Predicting the mutations generated by repair of Cas9-induced double-strand breaks Allen, Felicity; Crepaldi, Luca; Alsinet, Clara; Strong, Alexander J.; Kleshchevnikov, Vitalii; De Angeli, Pietro; Palenikova, Petra; Khodak, Anton; Kiselev, Vladimir; Kosicki, Michael; Bassett, Andrew R.; Harding, Heather; Galanty, Yaron; Munoz-Martinez, Francisco; Metzakopian, Emmanouil; Jackson, Stephen P.; Parts, Leopold 分享 收藏
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis Tschurtschenthaler, Markus; Adolph, Timon E.; Ashcroft, Jonathan W.; Niederreiter, Lukas; Bharti, Richa; Saveljeva, Svetlana; Bhattacharyya, Joya; Flak, Magdalena B.; Shih, David Q.; Fuhler, Gwenny M.; Parkes, Miles; Kohno, Kenji; Iwawaki, Takao; van der Woude, C. Janneke; Harding, Heather P.; Smith, Andrew M.; Peppelenbosch, Maikel P.; Targan, Stephan R.; Ron, David; Rosenstiel, Philip; Blumberg, Richard S.; Kaser, Arthur 分享 收藏
Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism Miyake, Masato; Nomura, Akitoshi; Ogura, Atsushi; Takehana, Kenji; Kitahara, Yoshihiro; Takahara, Kazuna; Tsugawa, Kazue; Miyamoto, Chinobu; Miura, Naoko; Sato, Ryosuke; Kurahashi, Kiyoe; Harding, Heather P.; Oyadomari, Miho; Ron, David; Oyadomari, Seiichi 分享 收藏
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