Zeger Debyser - Publications, H-index & Citations

Zeger Debyser

ku leuven

74H指数

762论文数

1.8W被引数

收录论文 205

发表时间

The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency LEDGIN GS-9822抑制HIV-2感染并增强HIV-2潜伏期

Microbiology Spectrum

IF3.8

2026-06-02

PREAI

Bruggemans, Anne; Vansant, Gerlinde; Pellaers, Eline; van de Velde, Paulien; Christ, Frauke; Debyser, Zeger

High-Affinity Nanobody Against the LEDGF PWWP Domain Inhibits Chromatin Binding In Vitro 高亲和力纳米抗体针对LEDGF PWWP结构域在体外抑制染色质结合

Biomolecules

IF4.8

2026-05-13

OAAI

Thibault Vantieghem; Sofie Jansen; Thatcher Zinabu Akele; Pieterjan Van Maele; Sam Noppen; Dominique Schols; Maarten Dewilde; Zeger Debyser; Sergei V. Strelkov

Deciphering the HIV reservoir: From epigenetic regulators to RNA-mediated regulation 解析HIV储库：从表观遗传调控因子到RNA介导的调控

Chinese Chemical Letters

IF8.9

2025-10-24

PREAI

Xiaojia Xue; Xiangyi Jiang; Jiaojiao Dai; Xinyong Liu; Eline Pellaers; Debyser Zeger; Peng Zhan

Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential LEDGF/p75 (PSIP1) 在肿瘤发生中的作用。分子机制和治疗潜力的见解。

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

IF8.3

2025-02-01

PREAI

Akele, Muluembet; Iervolino, Matteo; Van Belle, Siska; Christ, Frauke; Debyser, Zeger

Rational fragment-based design of compounds targeting the PWWP domain of the HRP family

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-12-01

PREAI

Vantieghem, Thibault; Aslam, Nayyar A.; Osipov, Evgenii M.; Akele, Muluembet; Van Belle, Siska; Beelen, Steven; Drexler, Matus; Paulovcakova, Terezia; Lux, Vanda; Fearon, Daren; Douangamath, Alice; von Delft, Frank; Christ, Frauke; Veverka, Vaclav; Verwilst, Peter; Van Aerschot, Arthur; Debyser, Zeger; Strelkov, Sergei V.

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia PSIP1/LEDGF在T细胞急性淋巴细胞白血病中的双重作用

SCIENCE ADVANCES

IF12.5

2024-11-01

OAAI

Demoen, Lisa; Matthijssens, Filip; Reunes, Lindy; Palhais, Bruno; Lintermans, Beatrice; T'Sas, Sara; Fijalkowski, Igor; Taminau, Joachim; Akele, Muluembet Z.; Van Belle, Siska; Taghon, Tom; Deforce, Dieter; Van Nieuwerburgh, Filip; Berx, Geert; Ntziachristos, Panagiotis; Debyser, Zeger; Durinck, Kaat; Pieters, Tim; Goossens, Steven; Van Vlierberghe, Pieter

Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells

CELL REPORTS MEDICINE

IF10.6

2024-05-01

OAAI

Bulcaen, Mattijs; Kortleven, Pheline; Liu, Ronald B.; Maule, Giulia; Dreano, Elise; Kelly, Mairead; Ensinck, Marjolein M.; Thierie, Sam; Smits, Maxime; Ciciani, Matteo; Hatton, Aurelie; Chevalier, Benoit; Ramalho, Anabela S.; Solvas, Xavier Casadevall i; Debyser, Zeger; Vermeulen, Francois; Gijsbers, Rik; Sermet-Gaudelus, Isabelle; Cereseto, Anna; Carlon, Marianne S.

Pharmacological advances in anti-retroviral therapy for human immunodeficiency virus-1 infection: A comprehensive review

REVIEWS IN MEDICAL VIROLOGY

IF6.6

2024-03-23

OAAI

Azzman, Nursyuhada; Gill, Muhammad Shoaib Ali; Hassan, Sharifah Syed; Christ, Frauke; Debyser, Zeger; Mohamed, Wan Ahmad Syazani; Ahemad, Nafees

The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function

CELLS

IF5.2

2024-01-25

OAAI

Brouns, Tine; Lux, Vanda; Van Belle, Siska; Christ, Frauke; Veverka, Vaclav; Debyser, Zeger

The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

JOURNAL OF VIRUS ERADICATION

IF2

2023-09-01

OAAI

Bruggemans, Anne; Vansant, Gerlinde; Van de Velde, Paulien; Debyser, Zeger

Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV-Based Vectors and for a Cure for HIV-1 Infection

VIRUSES-BASEL

IF3.5

2022-12-21

OAAI

Pellaers, Eline; Bhat, Anayat; Christ, Frauke; Debyser, Zeger

BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis

MICROBIOLOGY SPECTRUM

IF3.8

2022-08-31

OAAI

Nombela, Ivan; Michiels, Martine; Van Looveren, Dominique; Marcelis, Lukas; El Ashkar, Sara; Van Belle, Siska; Bruggemans, Anne; Tousseyn, Thomas; Schwaller, Jurg; Christ, Frauke; Gijsbers, Rik; De Rijck, Jan; Debyser, Zeger

Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

MBIO

IF4.7

2022-08-30

OAAI

Janssens, Julie; De Wit, Flore; Parveen, Nagma; Debyser, Zeger

Expansion microscopy allows high resolution single cell analysis of epigenetic readers

NUCLEIC ACIDS RESEARCH

IF13.1

2022-06-18

OAAI

Acke, Aline; Van Belle, Siska; Louis, Boris; Vitale, Raffaele; Rocha, Susana; Voet, Thierry; Debyser, Zeger; Hofkens, Johan

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

MICROBIOLOGY SPECTRUM

IF3.8

2021-10-31

OAAI

Janssens, Julie; Blokken, Jolien; Lampi, Yulia; De Wit, Flore; Bonisch, Irena Zurnic; Nombela, Ivan; Van de Velde, Paulien; Van Remoortel, Barbara; Gijsbers, Rik; Christ, Frauke; Debyser, Zeger

Role of Transportin-SR2 in HIV-1 Nuclear Import

VIRUSES-BASEL

IF3.5

2021-05-04

OAAI

Tabasi, Maryam; Nombela, Ivan; Janssens, Julie; Lahousse, Adrien P.; Christ, Frauke; Debyser, Zeger

GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-andLock Phenotype in Cell Culture

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2021-04-19

OAAI

Bruggemans, Anne; Vansant, Gerlinde; Balakrishnan, Mini; Mitchell, Michael L.; Cai, Ruby; Christ, Frauke; Debyser, Zeger

LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators

CANCER GENE THERAPY

IF5

2021-04-01

OAAI

Canella, Alessandro; Van Belle, Siska; Brouns, Tine; Nigita, Giovanni; Carlon, Marianne S.; Christ, Frauke; Debyser, Zeger

Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus

FRONTIERS IN MICROBIOLOGY

IF4.5

2021-03-18

OAAI

Janssens, Julie; Bruggemans, Anne; Christ, Frauke; Debyser, Zeger

Phage Display-Directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication (vol 20, pg 2064, 2012)

MOLECULAR THERAPY

IF12

2021-02-01

OAAI

Desimmie, Belete A.; Humbert, Michael; Lescrinier, Eveline; Hendrix, Jelle; Vets, Sofie; Gijsbers, Rik; Ruprecht, Ruth M.; Dietrich, Ursula; Debyser, Zeger; Christ, Frauke

研究方向