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PAT-Enabled Automated Feedforward Control: An Application to the Continuous Manufacture of Apremilast Hsieh, Hsiao-Wu; Griffin, Daniel J.; Nambiar, Anirudh M. K.; Sarkar, Nandini; Ismail, Hamza Youssef; Saigal, Kartik; Shen, Dongying Erin; Goudas-Salomon, Nicole; Wimalasinghe, Rasangi; Zeng, Alicia; Thiel, Oliver R.; Beaver, Matthew G. 分享 收藏
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A Continuous Process for Manufacturing Apremilast. Part II: Process Characterization to Establish a Parametric Control Strategy Griffin, Daniel J.; Hsieh, Hsiao-Wu; Avci, Nadide Hazal; Sarkar, Nandini; Fostinis, James D.; Klitzing, Nicholas; Murray, James I.; Wimalasinghe, Rasangi; Spada, Simone; Zeng, Alicia; Beaver, Matthew G. 分享 收藏
A Continuous Process for Manufacturing Apremilast. Part I: Process Development and Intensification by Utilizing Flow Chemistry Principles Hsieh, Hsiao-Wu; Cohen, Carolyn M.; Griffin, Daniel J.; Ananthoji, Padmini; Avci, Nadide Hazal; Brown, Derek B.; Ericson, Ari; Fostinis, James D.; Irfan, Muhammad; Langille, Neil; Lovette, Michael A.; Murray, James I.; Spada, Simone; Thiel, Oliver R.; Aiello, Frankie; Daou, Joseph; Goudas-Salomon, Nicole; Pan, Ende; Sarkar, Nandini; Wimalasinghe, Rasangi; Wu, Zufan Steven; Zeng, Alicia; Beaver, Matthew G. 分享 收藏
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Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor Zhang, Liang; Griffin, Daniel J.; Beaver, Matthew G.; Blue, Laura E.; Borths, Christopher J.; Brown, Derek B.; Caille, Seb; Chen, Ying; Cherney, Alan H.; Cochran, Brian M.; Colyer, John T.; Corbett, Michael T.; Correll, Tiffany L.; Crockett, Richard D.; Dai, Xi-Jie; Dornan, Peter K.; Farrell, Robert P.; Hedley, Simon J.; Hsieh, Hsiao-Wu; Huang, Liang; Huggins, Seth; Liu, Min; Lovette, Michael A.; Quasdorf, Kyle; Powazinik, William; Reifman, Jonathan; Robinson, Jo Anna; Sangodkar, Rahul P.; Sharma, Sonika; Kumar, Srividya Sharvan; Smith, Austin G.; St-Pierre, Gabrielle; Tedrow, Jason S.; Thiel, Oliver R.; Truong, Jonathan V.; Walker, Shawn D.; Wei, Carolyn S.; Wilsily, Ashraf; Xie, Yong; Yang, Ning; Parsons, Andrew T. 分享 收藏
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Accelerated Development of a Scalable Ring-Closing Metathesis to Manufacture AMG 176 Using a Combined High-Throughput Experimentation and Computational Modeling Approach St-Pierre, Gabrielle; Cherney, Alan H.; Chen, Wencan; Dong, Xiaofei; Dornan, Peter K.; Griffin, Daniel J.; Houk, K. N.; Lin, Janice B.; Osgood, Stephen; Elipe, Maria V. Silva; Timmons, Heath C.; Xie, Yong; Tedrow, Jason S.; Thiel, Oliver R.; Smith, Austin G. 分享 收藏
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A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration 用于集成连续生产卡非佐米原料药中间体的虚拟工厂，第3部分: 锰催化的不对称环氧化，结晶和过滤 Maloney, Andrew J.; Icten, Elcin; Capellades, Gerard; Beaver, Matthew G.; Zhu, Xiaoxiang; Graham, Lauren R.; Brown, Derek B.; Griffin, Daniel J.; Sangodkar, Rahul; Allian, Ayman; Huggins, Seth; Hart, Roger; Rolandi, Pablo; Walker, Shawn D.; Braatz, Richard D. 分享 收藏
Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis Struble, Thomas J.; Alvarez, Juan C.; Brown, Scott P.; Chytil, Milan; Cisar, Justin; DesJarlais, Renee L.; Engkvist, Ola; Frank, Scott A.; Greve, Daniel R.; Griffin, Daniel J.; Hou, Xinjun; Johannes, Jeffrey W.; Kreatsoulas, Constantine; Lahue, Brian; Mathea, Miriam; Mogk, Georg; Nicolaou, Christos A.; Palmer, Andrew D.; Price, Daniel J.; Robinson, Richard, I; Salentin, Sebastian; Xing, Li; Jaakkola, Tommi; Green, William H.; Barzilay, Regina; Coley, Connor W.; Jensen, Klays F. 分享 收藏
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