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收藏Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation
Chen, Gefei; Leppert, Axel; Poska, Helen; Nilsson, Harriet E.; Alvira, Carlos Piedrafita; Zhong, Xueying; Koeck, Philip; Jegerschold, Caroline; Abelein, Axel; Hebert, Hans; Johansson, Jan
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收藏Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue
Chen, Gefei; Andrade-Talavera, Yuniesky; Zhong, Xueying; Hassan, Sameer; Biverstal, Henrik; Poska, Helen; Abelein, Axel; Leppert, Axel; Kronqvist, Nina; Rising, Anna; Hebert, Hans; Koeck, Philip J. B.; Fisahn, Andre; Johansson, Jan
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收藏Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers
Trillo-Muyo, Sergio; Nilsson, Harriet E.; Recktenwald, Christian V.; Ermund, Anna; Ridley, Caroline; Meiss, Lauren N.; Baehr, Andrea; Klymiuk, Nikolai; Wine, Jeffrey J.; Koeck, Philip J. B.; Thornton, David J.; Hebert, Hans; Hansson, Gunnar C.
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收藏Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
Chen, Gefei; Abelein, Axel; Nilsson, Harriet E.; Leppert, Axel; Andrade-Talavera, Yuniesky; Tambaro, Simone; Hemmingsson, Lovisa; Roshan, Firoz; Landreh, Michael; Biverstal, Henrik; Koeck, Philip J. B.; Presto, Jenny; Hebert, Hans; Fisahn, Andre; Johansson, Jan
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收藏Structural model of dodecameric heat-shock protein Hsp21: Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity十二聚体热休克蛋白Hsp21的结构模型: 柔性N端臂与客户蛋白相互作用,而C端尾部保持十聚体和伴侣活性
Rutsdottir, Gudrun; Harmark, Johan; Weide, Yoran; Hebert, Hans; Rasmussen, Morten I.; Wernersson, Sven; Respondek, Michal; Akke, Mikael; Hojrup, Peter; Koeck, Philip J. B.; Soderberg, Christopher A. G.; Emanuelsson, Cecilia
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