Jan Johansson - Publications, H-index & Citations

Jan Johansson

karolinska institutet

77H指数

625论文数

2.2W被引数

收录论文 170

发表时间

Mechanism-selective inhibition of α-synuclein aggregation by the chaperone-like BRICHOS domain BRICHOS结构域对α-突触核蛋白聚集的机制选择性抑制

Journal of Biological Chemistry

IF3.9

2026-05-07

OAAI

Laurène Adam; Willem Hendrik Molenkamp; Jan Stanislaw Nowak; Azad Farzadfard; Koen Gaarthuis; Rakesh Kumar; Janni Nielsen; Daniel E. Otzen; Jan Johansson; Axel Abelein

Bri2 BRICHOS, a molecular chaperone-like domain that can cross brain vascular endothelial cells and deliver proteins into neurons Bri2 BRICHOS，一种分子伴侣样结构域，能够穿过脑血管内皮细胞并将蛋白质递送至神经元

Journal of Controlled Release

IF11.5

2025-11-10

OAAI

Helene Tigro; Cloé Moëlo; Josef Pelcman; Wojciech Paslawski; Gefei Chen; Helen Poska; Ruth Shimmo; Per Svenningsson; Nina Kronqvist; Jan Johansson

The effect of colored overlays on reading in patients with acquired brain injury 脑损伤患者在阅读中使用彩色遮光板的效应

BRAIN INJURY

IF1.8

2025-09-01

PREAI

Westrom, Sarah; Hybbinette, Helena; Gode, Kajsa; Johansson, Jan

Intravenous chaperone treatment of late-stage Alzheimers disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes

TRANSLATIONAL PSYCHIATRY

IF6.2

2024-10-24

OAAI

Zhang, Ruixin; Ohshima, Makiko; Brodin, David; Wang, Yu; Morance, Antonin; Schultzberg, Marianne; Chen, Gefei; Johansson, Jan

Origin, structure, and composition of the spider major ampullate silk fiber revealed by genomics, proteomics, and single-cell and spatial transcriptomics

SCIENCE ADVANCES

IF12.5

2024-08-16

PREAI

Sonavane, Sumalata; Hassan, Sameer; Chatterjee, Urmimala; Soler, Lucile; Holm, Lena; Mollbrink, Annelie; Greco, Gabriele; Fereydouni, Noah; Vinnere Pettersson, Olga; Bunikis, Ignas; Churcher, Allison; Lantz, Henrik; Johansson, Jan; Reimegard, Johan; Rising, Anna

Treatment with BRICHOS domain helps to clarify issues with Alzheimer mouse models

EMBO MOLECULAR MEDICINE

IF8.3

2024-03-13

OAAI

Johansson, Jan

Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain

NATURE COMMUNICATIONS

IF15.7

2024-02-01

OAAI

Kumar, Rakesh; Le Marchand, Tanguy; Adam, Laurene; Bobrovs, Raitis; Chen, Gefei; Fridmanis, Jekabs; Kronqvist, Nina; Biverstal, Henrik; Jaudzems, Kristaps; Johansson, Jan; Pintacuda, Guido; Abelein, Axel

Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome

TRANSLATIONAL RESEARCH

IF5.9

2023-12-01

OAAI

Mikolka, Pavol; Kronqvist, Nina; Haegerstrand-Bjorkman, Marie; Jaudzems, Kristaps; Kosutova, Petra; Kolomaznik, Maros; Saluri, Mihkel; Landreh, Michael; Calkovska, Andrea; Curstedt, Tore; Johansson, Jan

Spider Silk Protein Forms Amyloid-Like Nanofibrils through a Non-Nucleation-Dependent Polymerization Mechanism (Small 46/2023)

SMALL

IF12.1

2023-11-15

OAAI

Qi, Xingmei; Wang, Yu; Yu, Hairui; Liu, Ruifang; Leppert, Axel; Zheng, Zihan; Zhong, Xueying; Jin, Zhen; Wang, Han; Li, Xiaoli; Wang, Xiuzhe; Landreh, Michael; Morozova-Roche, Ludmilla A.; Johansson, Jan; Xiong, Sidong; Iashchishyn, Igor; Chen, Gefei

Identification of glycolytic proteins as binding partners of Bri2 BRICHOS domain

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2023-08-01

PREAI

Tigro, Helene; Shimozawa, Makoto; Nilsson, Per; Lyashkov, Alexey; Khadeer, Mohammed; Järving, Ivar; Ferrucci, Luigi; Shimmo, Ruth; Johansson, Jan; Moaddel, Ruin

Spider Silk Protein Forms Amyloid-Like Nanofibrils through a Non-Nucleation-Dependent Polymerization Mechanism

SMALL

IF12.1

2023-07-16

OAAI

Misfolded alpha-synuclein detection by RT-QuIC in dementia with lewy bodies: a systematic review and meta-analysis 通过rt-quic检测路易体痴呆患者的错误折叠 α-突触核蛋白: 系统评价和荟萃分析

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2023-05-17

OAAI

Pena-Bautista, Carmen; Kumar, Rakesh; Baquero, Miguel; Johansson, Jan; Chafer-Pericas, Consuelo; Abelein, Axel; Ferreira, Daniel

Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation

COMMUNICATIONS BIOLOGY

IF5.1

2023-05-08

OAAI

Chen, Gefei; Leppert, Axel; Poska, Helen; Nilsson, Harriet E.; Alvira, Carlos Piedrafita; Zhong, Xueying; Koeck, Philip; Jegerschold, Caroline; Abelein, Axel; Hebert, Hans; Johansson, Jan

Molecular Mechanisms of Amyloid-? Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone

ACS CHEMICAL NEUROSCIENCE

IF3.9

2023-04-06

OAAI

Kumar, Rakesh; Arroyo-Garcia, Luis Enrique; Manchanda, Shaffi; Adam, Laurene; Pizzirusso, Giusy; Biverstal, Henrik; Nilsson, Per; Fisahn, Andre; Johansson, Jan; Abelein, Axel

Intravenous treatment with a molecular chaperone designed against f3-amyloid toxicity improves Alzheimer?s disease pathology in mouse models

MOLECULAR THERAPY

IF12

2023-02-01

OAAI

Manchanda, Shaffi; Galan-Acosta, Lorena; Abelein, Axel; Tambaro, Simone; Chen, Gefei; Nilsson, Per; Johansson, Jan

A grappling hook interaction connects self-assembly and chaperone activity of Nucleophosmin 1

PNAS NEXUS

IF3.8

2023-01-06

OAAI

Saluri, Mihkel; Leppert, Axel; Gese, Genis Valentin; Sahin, Cagla; Lama, Dilraj; Kaldmae, Margit; Chen, Gefei; Elofsson, Arne; Allison, Timothy M.; Arsenian-Henriksson, Marie; Johansson, Jan; Lane, David P.; Hallberg, B. Martin; Landreh, Michael

Amyloid inhibition by molecular chaperones in vitro can be translated to Alzheimer's pathology in vivo

RSC MEDICINAL CHEMISTRY

IF3.6

2023-01-01

OAAI

Abelein, Axel; Johansson, Jan

S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS

PROGRESS IN NEUROBIOLOGY

IF6.1

2022-12-01

PREAI

Andrade-Talavera, Yuniesky; Chen, Gefei; Pansieri, Jonathan; -Garcia, Luis Enrique Arroyo; Toleikis, Zigmantas; Smirnovas, Vytautas; Johansson, Jan; Morozova-Roche, Ludmilla; Fisahn, Andre

Impact of physio-chemical spinning conditions on the mechanical properties of biomimetic spider silk fibers

COMMUNICATIONS MATERIALS

IF9.6

2022-11-04

OAAI

Schmuck, Benjamin; Greco, Gabriele; Backlund, Fredrik G.; Pugno, Nicola M.; Johansson, Jan; Rising, Anna

Mass Spectrometry and Machine Learning Reveal Determinants of Client Recognition by Antiamyloid Chaperones

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2022-10-01

OAAI

Osterlund, Nicklas; Vosselman, Thibault; Leppert, Axel; Graslund, Astrid; Jornvall, Hans; Ilag, Leopold L.; Marklund, Erik G.; Elofsson, Arne; Johansson, Jan; Sahin, Cagla; Landreh, Michael

研究方向