Hyukjin Lee

seoul national university

H指数:48

被引数:9,564

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Patient-derived teratomas as a humanized platform for dystrophin restoration by ex vivo cell therapy and in vivo base editing

患者来源的畸胎瘤作为异种移植平台，用于通过体外细胞疗法和体内碱基编辑恢复抗肌萎缩蛋白

Experimental and Molecular Medicine

IF12.9

2026-10-010

OAAI

Mutation-agnostic base editing of the progerin farnesylation site rescues Hutchinson-Gilford progeria syndrome phenotypes in neuromuscular organoids

针对早衰蛋白法尼基化位点的突变非依赖性碱基编辑在神经肌肉类器官中拯救了贺金-吉尔福德早衰综合征表型

Nature Communications

IF15.7

2026-08-310

Inflammatory and immune-mediated toxicity of lipid nanoparticles

脂质纳米颗粒的炎症和免疫介导毒性

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2026-04-190

OAAI

mRNA based in vivo MG1113 antibody production as a potential therapeutic approach for hemophilia

基于mRNA的在体MG1113抗体生产作为一种治疗血友病的潜在方法

Journal of Controlled Release

IF11.5

2025-12-070

OAAI

RNA stability enhancers for durable base-modified mRNA therapeutics

RNA稳定性增强剂用于持久的碱基修饰mRNA治疗

Nature Biotechnology

IF41.7

2025-11-070

PRE

Advances in mRNA-Lipid Nanoparticle Engineering for Immune Cell Targeting and Immune Modulation

mRNA-脂质纳米粒工程在免疫细胞靶向和免疫调控方面的进展

Small Methods

IF9.1

2025-09-160

PRE

Advances in the rational design of ionizable lipids for mRNA therapeutics

可电离脂质在mRNA疗法中理性设计的进展

materials today advances

IF22

2025-07-310

PRE

Development of lipid nanoparticle formulation for intramuscular administration of mRNA vaccine against respiratory syncytial virus

JOURNAL OF PHARMACEUTICAL INVESTIGATION

IF5.1

2025-01-220

PRE

GTSE1-driven ZEB1 stabilization promotes pulmonary fibrosis through the epithelial-to-mesenchymal transition

MOLECULAR THERAPY

IF12

2024-11-011

OAAI

Optimization of polyethylene glycol shielding and mannose density on the lipid nanoparticles for efficient delivery to macrophages and spleens

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2024-09-011

PRE

Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site

NATURE COMMUNICATIONS

IF15.7

2024-08-271

OAAI

Effects of Histidine Oligomers in Lipid Nanoparticles on siRNA Delivery

MACROMOLECULAR BIOSCIENCE

IF4.1

2024-06-210

PRE

Development of Lipid Nanoparticle Formulation for the Repeated Administration of mRNA Therapeutics

BIOMATERIALS RESEARCH

IF9.6

2024-05-222

OAAI

Oligonucleotide therapeutics and their chemical modification strategies for clinical applications

JOURNAL OF PHARMACEUTICAL INVESTIGATION

IF5.1

2024-02-294

PRE

In vivo genome editing using 244-cis LNPs and low-dose AAV achieves therapeutic threshold in hemophilia A mice

MOLECULAR THERAPY NUCLEIC ACIDS

IF6.1

2023-12-019

OAAI

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

脂质纳米粒的免疫原性及其对mRNA疫苗和治疗效果的影响

EXPERIMENTAL AND MOLECULAR MEDICINE

IF12.9

2023-10-0271

OAAI

Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

ADVANCED DRUG DELIVERY REVIEWS

IF17.6

2023-09-0159

PRE

In vivo genome editing for hemophilia B therapy by the combination of rebalancing and therapeutic gene knockin using a viral and non-viral vector

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2023-06-0117

OAAI

Novel piperazine-based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety

基于哌嗪的新型可电离脂质纳米颗粒允许重复剂量的mRNA到纤维化肺，具有改善的效力和安全性

BIOENGINEERING & TRANSLATIONAL MEDICINE

IF5.7

2023-05-2814

OAAI

Development of a Real-Time 6-DOF Motion-Tracking System for Robotic Computer-Assisted Implant Surgery

用于机器人计算机辅助植入手术的实时六自由度运动跟踪系统的开发

SENSORS

IF3.5

2023-02-2210

OAAI

Hyukjin Lee

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