Mengyuan Zhu

china pharmaceutical university

H指数:11

被引数:283

个人简介

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Discovery of Pyrrolo[1′; 2′:1; 6]pyrimido[5; 4-c]pyridazin-6(5H)-one Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Inhibitors

吡咯并[1′; 2′:1; 6]嘧啶并[5; 4-c]哒嗪-6(5H)-酮衍生物作为外核苷焦磷酸酶/磷酸二酯酶1抑制剂的发现

Journal of Medicinal Chemistry

IF6.8

2026-05-260

PRE

BUB1 promotes lung adenocarcinoma progression by regulating STAT3/GPX4-mediated ferroptosis

BUB1通过调控STAT3/GPX4-mediated铁死亡促进肺腺癌进展

Frontiers in Oncology

IF3.3

2026-02-020

OAAI

Overcoming ELDR-Mediated Cancer Cell Survival in vitro and in vivo via Sphingomyelin-Driven TRPML1 Inactivation and TFEB Suppression through Lysosomal HSP70 Targeting

通过靶向溶酶体HSP70，克服ELDR介导的癌细胞在体内外生存，经由鞘磷脂驱动的TRPML1失活和TFEB抑制。

Pharmacological Research

IF10.5

2025-12-050

OAAI

PARP1-mediated PARylation of TEAD4 stabilizes the YAP1-TEAD4 complex and promotes growth and immune evasion in breast cancer cells

PARP1介导的TEAD4泛素化修饰稳定YAP1-TEAD4复合物，并促进乳腺癌细胞的生长和免疫逃逸。

Science Signaling

IF6.6

2025-10-210

PRE

Sustainable production of microporous activated carbon spheres from pineapple waste for efficient CO2 capture

从菠萝废弃物中可持续生产微孔活性炭球，用于高效CO2捕获

Journal of Environmental Chemical Engineering

IF7.2

2025-08-180

PRE

Development and characterisation of [18F]TTDP, a novel T cell immunoglobulin and ITIM domain tracer, in humanised mice and non-human primates

European Journal of Nuclear Medicine and Molecular Imaging

IF7.6

2024-09-190

PRE

Paclitaxel combined with Compound K inducing pyroptosis of non-small cell lung cancer cells by regulating Treg/Th17 balance

CHINESE MEDICINE

IF5.7

2024-02-155

OAAI

Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies

CLINICAL AND TRANSLATIONAL MEDICINE

IF6.8

2023-03-234

OAAI

Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218

ACTA PHARMACEUTICA SINICA B

IF14.6

2021-10-0119

OAAI

The Prognostic Value of a Tumor Microenvironment-Based Immune Cell Infiltration Score Model in Colon Cancer

基于肿瘤微环境的免疫细胞浸润评分模型在结肠癌中的预后价值

FRONTIERS IN ONCOLOGY

IF3.3

2021-09-273

OAAI

Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia

CELL COMMUNICATION AND SIGNALING

IF8.9

2021-08-0910

OAAI

Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2020-10-0121

OAAI

Natural HDAC-1/8 inhibitor baicalein exerts therapeutic effect in CBF-AML

CLINICAL AND TRANSLATIONAL MEDICINE

IF6.8

2020-08-2627

OAAI

LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis

LW-213通过激活PERK-eIF2α-ATF4-CHOP轴诱导人皮肤T细胞淋巴瘤的细胞凋亡

ACTA PHARMACOLOGICA SINICA

IF8.4

2020-08-0314

OAAI

GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2019-12-0111

PREAI

Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9

ARCHIVES OF TOXICOLOGY

IF6.9

2019-11-2313

PREAI

LW-213, a newly synthesized flavonoid, induces G2/M phase arrest and apoptosis in chronic myeloid leukemia

LW-213，一种新合成的黄酮类化合物，在慢性粒细胞白血病中诱导G2/M期阻滞和凋亡

ACTA PHARMACOLOGICA SINICA

IF8.4

2019-07-179

OAAI

Design, Synthesis, and Antitumor Evaluation of 4-Amino-(1H)-pyrazole Derivatives as JAKs Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2016-08-2428

OAAI

Mengyuan Zhu

个人简介

教育背景

工作经历

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