Sigurd Elz - Publications, H-index & Citations

Sigurd Elz

university of regensburg

27H指数

140论文数

2.2K被引数

收录论文 40

发表时间

Novel water-soluble and highly efficient dual type I/II next generation inhibitors of FMS-like tyrosine kinase 3 (FLT3)新型水溶性且高效的双重类型I/II下一代FMS样酪氨酸激酶3（FLT3）抑制剂

European Journal of Medicinal Chemistry

IF5.9

2025-06-08

PREAI

Andreas Sellmer; Marina Able; Karsten Spiekermann; Maria Reinecke; Bernhard Kuster; Kirsten Utpatel; Lukas Wirth; Herwig Pongratz; Nicole Plank; Pierre Koch; Sigurd Elz; Amrei Fischer; Belay Tizazu; Heinz-Herbert Fiebig; Stefan Dove; Siavosh Mahboobi

Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-03-01

PREAI

Szczepanska, Katarzyna; Pockes, Steffen; Podlewska, Sabina; Horing, Carina; Mika, Kamil; Latacz, Gniewomir; Bednarski, Marek; Siwek, Agata; Karcz, Tadeusz; Nagl, Martin; Bresinsky, Merlin; Monnich, Denise; Seibel, Ulla; Kuder, Kamil J.; Kotanska, Magdalena; Stark, Holger; Elz, Sigurd; Kiec-Kononowicz, Katarzyna

A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia 一系列新型芳基甲酮衍生物作为FLT3-ITD-positive急性髓系白血病中FMS样酪氨酸激酶3 (FLT3) 的抑制剂

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-05-01

PREAI

Sellmer, Andreas; Pilsl, Bernadette; Beyer, Mandy; Pongratz, Herwig; Wirth, Lukas; Elz, Sigurd; Dove, Stefan; Henninger, Sven Julian; Spiekermann, Karsten; Polzer, Harald; Klaeger, Susan; Kuster, Bernhard; Boehmer, Frank D.; Fiebig, Heinz-Herbert; Kraemer, Oliver H.; Mahboobi, Siavosh

Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors 四氢-β-咔啉衍生物作为高效组蛋白去乙酰化酶6 (HDAC6) 抑制剂的设计和生物学评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-05-01

PREAI

Leonhardt, Michel; Sellmer, Andreas; Kraemer, Oliver H.; Dove, Stefan; Elz, Sigurd; Kraus, Birgit; Beyer, Mandy; Mahboobi, Siavosh

Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-03-28

PREAI

Sellmer, Andreas; Stangl, Hubert; Beyer, Mandy; Gruenstein, Elisabeth; Leonhardt, Michel; Pongratz, Herwig; Eichhorn, Emerich; Elz, Sigurd; Striegl, Birgit; Jenei-Lanzl, Zsuzsa; Dove, Stefan; Straub, Rainer H.; Kraemer, Oliver H.; Mahboobi, Siavosh

Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists

ACS OMEGA

IF4.3

2018-03-09

OAAI

Pockes, Steffen; Wifling, David; Keller, Max; Buschauer, Armin; Elz, Sigurd

Label-free versus conventional cellular assays: Functional investigations on the human histamine H1 receptor

PHARMACOLOGICAL RESEARCH

IF10.5

2016-12-01

PREAI

Lieb, S.; Littmann, T.; Plank, N.; Felixberger, J.; Tanaka, M.; Schafer, T.; Krief, S.; Elz, S.; Friedland, K.; Bernhardt, G.; Wegener, J.; Ozawa, T.; Buschauer, A.

Dibenzo[bf][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs

PHARMACOLOGICAL RESEARCH

IF10.5

2016-11-01

PREAI

Naporra, Franziska; Gobleder, Susanne; Wittmann, Hans Joachim; Spindler, Julia; Bodensteiner, Michael; Bernhardt, Guenther; Huebner, Harald; Gmeiner, Peter; Elz, Sigurd; Strasser, Andrea

[3H]UR-DE257: Development of a Tritium-Labeled Squaramide-Type Selective Histamine H2 Receptor Antagonist

CHEMMEDCHEM

IF3.4

2014-10-15

PREAI

Baumeister, Paul; Erdmann, Daniela; Biselli, Sabrina; Kagermeier, Nicole; Elz, Sigurd; Bernhardt, Guenther; Buschauer, Armin

Pharmacological profile of astemizole-derived compounds at the histamine H1 and H4 receptor-H1/H4 receptor selectivity

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IF3.1

2013-11-17

PREAI

Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea

Synthesis and Dual Histamine H1 and H2 Receptor Antagonist Activity of Cyanoguanidine Derivatives

MOLECULES

IF4.6

2013-11-15

OAAI

Sadek, Bassem; Alisch, Rudi; Buschauer, Armin; Elz, Sigurd

The Bivalent Ligand Approach Leads to Highly Potent and Selective Acylguanidine-Type Histamine H2 Receptor Agonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-01-25

PREAI

Birnkammer, Tobias; Spickenreither, Anja; Brunskole, Irena; Lopuch, Miroslaw; Kagermeier, Nicole; Bernhardt, Guenther; Dove, Stefan; Seifert, Roland; Elz, Sigurd; Buschauer, Armin

N α-Methylated phenylhistamines exhibit affinity to the hH4R-a pharmacological and molecular modelling study

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IF3.1

2011-07-29

PREAI

Wittmann, Hans-Joachim; Elz, Sigurd; Seifert, Roland; Strassler, Andrea

Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor 部分激动剂与5-HT2A受体相互作用的理论研究

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IF3.1

2010-11-19

PREAI

Silva, Maria Elena; Heim, Ralf; Strasser, Andrea; Elz, Sigurd; Dove, Stefan

NG-Acylated Imidazolylpropylguanidines as Potent Histamine H4 Receptor Agonists: Selectivity by Variation of the NG-Substituent

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2009-03-24

PREAI

Igel, Patrick; Schneider, Erich; Schnell, David; Elz, Sigurd; Seifert, Roland; Buschauer, Armin

Molecular Basis for the Selective Interaction of Synthetic Agonists with the Human Histamine H1-Receptor Compared with the Guinea Pig H1-Receptor

MOLECULAR PHARMACOLOGY

IF3

2009-03-01

PREAI

Strasser, Andrea; Wittmann, Hans-Joachim; Kunze, Marc; Elz, Sigurd; Seifert, Roland

NG-Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H2 Receptor Agonists

CHEMMEDCHEM

IF3.4

2009-02-04

PREAI

Kraus, Anja; Ghorai, Prasanta; Birnkammer, Tobias; Schnell, David; Elz, Sigurd; Seifert, Roland; Dove, Stefan; Bernhardt, Guenther; Buschauer, Armin

Acylguanidines as Bioisosteres of Guanidines: NG-Acylated Imidazolylpropylguanidines, a New Class of Histamine H2 Receptor Agonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-10-25

PREAI

Ghorai, Prasanta; Kraus, Anja; Keller, Max; Goette, Carsten; Igel, Patrick; Schneider, Erich; Schnell, David; Bernhardt, Guenther; Dove, Stefan; Zabel, Manfred; Elz, Sigurd; Seifert, Roland; Buschauer, Armin

Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl) amides -: A SAR study on the bioisosterism of pyrimidine and imidazole

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2008-07-01

PREAI

Mahboobi, Siavosh; Sellmer, Andreas; Eswayah, Asma; Elz, Sigurd; Uecker, Andrea; Boehmer, Frank-D.

Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2007-03-01

PREAI

Mahboobi, Siavosh; Uecker, Andrea; Cenac, Christophe; Sellmer, Andreas; Eichhorn, Emerich; Elz, Sigurd; Boehmer, Frank-D.; Dove, Stefan

研究方向