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E

E. Spielvogel

University of North Carolina at Chapel Hill

H指数:9

被引数:250

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Fluorinated HIV-1 Protease Inhibitors Containing Chiral Hydroxyethylbenzene and Indanol as P2′ Ligands with Potent Activity Against Drug-Resistant Variants

含手性羟乙基苯和吲哚醇作为P2′配体的氟化HIV-1蛋白酶抑制剂，对耐药变异体具有显著活性

European Journal of Medicinal Chemistry

IF5.9

2025-12-190

PRE

Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1

IF4.7

2024-04-102

OAAI

HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-09-015

OAAI

Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

IF0

2023-03-1510

OA

Unique Molecular Identifiers and Multiplexing Amplicons Maximize the Utility of Deep Sequencing To Critically Assess Population Diversity in RNA Viruses

ACS INFECTIOUS DISEASES

IF3.8

2022-11-037

OA

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-07-166

OAAI

HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2′ Ligands To Optimize Hydrogen Bonding in the Substrate Envelope

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-08-0624

OAAI

Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance

ACS CHEMICAL BIOLOGY

IF3.8

2019-07-3035

OAAI

Prevalence of Drug-Resistant Minority Variants in Untreated HIV-1-Infected Individuals With and Those Without Transmitted Drug Resistance Detected by Sanger Sequencing

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2017-07-2527

OAAI