Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype HybridizationJOURNAL OF MEDICINAL CHEMISTRYIF6.82022-02-0219PRE
Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and PsoriasisACS MEDICINAL CHEMISTRY LETTERSIF42021-04-306OA
Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313JOURNAL OF MEDICINAL CHEMISTRYIF6.82021-02-1612PREAI
Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening ApproachACS MEDICINAL CHEMISTRY LETTERSIF42020-11-0617OAAI
Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis烟酰胺作为有效和选择性IRAK4抑制剂的优化，在银屑病小鼠模型中具有疗效ACS MEDICINAL CHEMISTRY LETTERSIF42020-06-1011OAAI
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse AgonistACS MEDICINAL CHEMISTRY LETTERSIF42020-03-3137OAAI
Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo EfficacyJOURNAL OF MEDICINAL CHEMISTRYIF6.82019-10-2233PREAI
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yI)sulfones as Selective, Orally Active RORγt Inverse AgonistsACS MEDICINAL CHEMISTRY LETTERSIF42019-02-2647OAAI
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid ArthritisACS MEDICINAL CHEMISTRY LETTERSIF42019-02-1312OAAI
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (P13Kδ) Inhibitor for the Treatment of Immunological DisordersJOURNAL OF MEDICINAL CHEMISTRYIF6.82017-06-0517PREAI
N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent (vol 47, pg 1719, 2004)JOURNAL OF MEDICINAL CHEMISTRYIF6.82015-09-023OAAI
Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine InhibitorsACS MEDICINAL CHEMISTRY LETTERSIF42015-07-1419OAAI
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative NeoplasmsACS MEDICINAL CHEMISTRY LETTERSIF42015-07-1436OAAI
X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family KinaseCHEMICAL BIOLOGY & DRUG DESIGNIF3.32011-09-2123OAAI
Structural basis for CARM1 inhibition by indole and pyrazole inhibitorsBIOCHEMICAL JOURNALIF4.32011-05-13100OA
Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory DiseasesJOURNAL OF MEDICINAL CHEMISTRYIF6.82010-08-3063PREAI
Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical DevelopmentJOURNAL OF MEDICINAL CHEMISTRYIF6.82009-09-2497PREAI
N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore ReorientationJOURNAL OF MEDICINAL CHEMISTRYIF6.82009-04-0732PREAI
Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase SuperfamilyJOURNAL OF MEDICINAL CHEMISTRYIF6.82009-02-13306PREAI
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: Synthesis, X-ray crystallographic analysis, and biological activitiesJOURNAL OF MEDICINAL CHEMISTRYIF6.82008-08-09146PREAI
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