未登录 Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles 与转铁蛋白受体1结合的Bicycle肽偶联可增强ASO和siRNA在骨骼肌和心肌中的效力 Ostergaard, Michael E.; Carrer, Michele; Anderson, Brooke A.; Afetian, Megan; Bakooshli, Mohsen A.; Santos, Jinro A.; Klein, Stephanie K.; Capitanio, Juliana; Freestone, Graeme C.; Tanowitz, Michael; Galindo-Murillo, Rodrigo; Gaus, Hans J.; Dwyer, Chrissa A.; Jackson, Michaela; Jafar-nejad, Paymaan; Rigo, Frank; Seth, Punit P.; Gaynor, Katherine U.; Stanway, Steven J.; Urbonas, Liudvikas; St. Denis, Megan A.; Pellegrino, Simone; Bezerra, Gustavo A.; Rigby, Michael; Gowans, Ellen; Van Rietschoten, Katerine; Beswick, Paul; Skynner, Michael J.; Swayze, Eric E. 分享 收藏
Tool to Resolve Distortions in Elemental and Isotopic Imaging Lu, Chixiang; Chen, Gu; Song, Wenxin; Chen, Kai; Hee, Charmaine; Nikan, Mehran; Guagliardo, Paul; Bennett, C. Frank; Seth, Punit; Iyer, Killugudi Swaminathan; Young, Stephen G.; Qi, Xiaojuan; Jiang, Haibo 分享 收藏
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides Genna, Vito; Iglesias-Fernandez, Javier; Reyes-Fraile, Laura; Villegas, Nuria; Guckian, Kevin; Seth, Punit; Wan, Brad; Cabrero, Cristina; Terrazas, Montserrat; Brun-Heath, Isabelle; Gonzalez, Carlos; Sciabola, Simone; Villalobos, Anabella; Orozco, Modesto 分享 收藏
Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA Rajasekaran, Tamilselvan; Freestone, Graeme C.; Galindo-Murillo, Rodrigo; Lugato, Barbara; Gaus, Hans; Migawa, Michael T.; Swayze, Eric. E.; Cheatham III, Thomas E.; Seth, Punit P.; Hanessian, Stephen 分享 收藏
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics Finicle, Brendan T.; Eckenstein, Kazumi H.; Revenko, Alexey S.; Anderson, Brooke A.; Wan, W. Brad; McCracken, Alison N.; Gil, Daniel; Fruman, David A.; Hanessian, Stephen; Seth, Punit P.; Edinger, Aimee L. 分享 收藏
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Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging Mukherjee, Prabuddha; Aksamitiene, Edita; Alex, Aneesh; Shi, Jindou; Bera, Kajari; Zhang, Chi; Spillman, Darold R., Jr.; Marjanovic, Marina; Fazio, Michael; Seth, Punit P.; Frazier, Kendall; Hood, Steve R.; Boppart, Stephen A. 分享 收藏
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Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA Rajasekaran, Tamilselvan; Freestone, Graeme C.; Galindo-Murillo, Rodrigo; Lugato, Barbara; Rico, Lorena; Salinas, Juan C.; Gaus, Hans; Migawa, Michael T.; Swayze, Eric E.; Cheatham, Thomas E., III; Hanessian, Stephen; Seth, Punit P. 分享 收藏
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides Anderson, Brooke A.; Freestone, Graeme C.; Low, Audrey; De-Hoyos, Cheryl L.; Drury, William J., III; Ostergaard, Michael E.; Migawa, Michael T.; Fazio, Michael; Wan, W. Brad; Berdeja, Andres; Scandalis, Eli; Burel, Sebastien A.; Vickers, Timothy A.; Crooke, Stanley T.; Swayze, Eric E.; Liang, Xuehai; Seth, Punit P. 分享 收藏
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS Nagata, Tetsuya; Dwyer, Chrissa A.; Yoshida-Tanaka, Kie; Ihara, Kensuke; Ohyagi, Masaki; Kaburagi, Hidetoshi; Miyata, Haruka; Ebihara, Satoe; Yoshioka, Kotaro; Ishii, Takashi; Miyata, Kanjiro; Miyata, Kenichi; Powers, Berit; Igari, Tomoko; Yamamoto, Syunsuke; Arimura, Naoto; Hirabayashi, Hideki; Uchihara, Toshiki; Hara, Rintaro Iwata; Wada, Takeshi; Bennett, C. Frank; Seth, Punit P.; Rigo, Frank; Yokota, Takanori 分享 收藏
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iRGD-Liposomes Enhance Tumor Delivery and Therapeutic Efficacy of Antisense Oligonucleotide Drugs against Primary Prostate Cancer and Bone Metastasis iRGD-脂质体增强反义寡核苷酸药物对原发性前列腺癌和骨转移的肿瘤递送和治疗效果 Guan, Jibin; Guo, Hong; Tang, Tang; Wang, Yihan; Wei, Yushuang; Seth, Punit; Li, Yingming; Dehm, Scott M.; Ruoslahti, Erkki; Pang, Hong-Bo 分享 收藏
Site-specific Incorporation of 2′,5′-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides Prakash, Thazha P.; Yu, Jinghua; Shen, Wen; De Hoyos, Cheryl Li; Berdeja, Andres; Gaus, Hans; Liang, Xue-hai; Crooke, Stanley T.; Seth, Punit P. 分享 收藏
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell Knerr, Laurent; Prakash, Thazha P.; Lee, Richard; Drury, William J., III; Nikan, Mehran; Fu, Wuxia; Pirie, Elaine; De Maria, Leonardo; Valeur, Eric; Hayen, Ahlke; Olwegard-Halvarsson, Maria; Broddefalk, Johan; Ammala, Carina; Ostergaard, Michael E.; Meuller, Johan; Sundstrom, Linda; Andersson, Patrik; Janzen, David; Jansson-Lofmark, Rasmus; Seth, Punit P.; Andersson, Shalini 分享 收藏
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs Vasquez, Guillermo; Freestone, Graeme C.; Wan, W. Brad; Low, Audrey; Li De Hoyos, Cheryl; Yu, Jinghua; Prakash, Thazha P.; Ostergaard, Michael E.; Liang, Xue-hai; Crooke, Stanley T.; Swayze, Eric E.; Migawa, Michael T.; Seth, Punit P. 分享 收藏
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High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS) He, Cuiwen; Migawa, Michael T.; Chen, Kai; Weston, Thomas A.; Tanowitz, Michael; Song, Wenxin; Guagliardo, Paul; Iyer, K. Swaminathan; Bennett, C. Frank; Fong, Loren G.; Seth, Punit P.; Young, Stephen G.; Jiang, Haibo 分享 收藏
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