Zhicai Shi - Publications, H-index & Citations

Zhicai Shi

Johnson & Johnson

13H指数

44论文数

1.6K被引数

收录论文 21

发表时间

Catalyst-Free C-N Coupling under Ambient Conditions via High-Throughput Microdroplet Reactions 无催化剂条件下常温下的高通量微液滴反应实现C-N偶联

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2025-12-01

PREAI

Li, Jie; Aikonen, Santeri; Morato, Nicolas M.; Hao, Bo; Shi, Zhicai; Strambeanu, Iulia I.; Cooks, R. Graham

On-DNA Deoxygenative C(sp2)–C(sp3) Coupling Facilitated by Surfactant–DNA (Surf-DNA) Workflow DNA上的脱氧C(sp2)–C(sp3)偶联，由表面活性剂–DNA（Surf-DNA）工作流程促进

Organic Letters

IF5

2025-10-09

PREAI

Pratik R. Chheda; Dominic S. Finis; Nicholas Simmons; Zhicai Shi

Surf–DNA-Enabled DNA-Encoded Library-Compatible Amino Radical Transfer C(sp2)–C(sp3) Coupling Surf–DNA支持的、与DNA编码文库兼容的氨基自由基转移C(sp²)–C(sp³)偶联

Organic Letters

IF5

2025-08-05

PREAI

Dominic S. Finis; Nicholas Simmons; Zhicai Shi; Pratik R. Chheda

Automated high-throughput RP-HPLC-MS and SFC-MS analytical and purification platforms to support drug discovery 自动化高通量rp-hplc-ms和sfc-ms分析和纯化平台，支持药物发现

JOURNAL OF CHROMATOGRAPHY A

IF4

2025-02-01

PREAI

Chen, Kuanchang; Dores-Sousa, Jose Luis; Fontana, Alberto; Grosanu, Cristina; Mcallister, Heather M.; Bai, Guoyun; Bartkowiak, Karolina; Canellas, Santiago; Corens, David; De Groot, Alex; Nevarez, Juan; Serrano, Marta; Raeymaekers, Kristien; Rodriguez, Raquel; Van Eynde, Lars; Zhou, Ronghui; Shi, Zhicai

Modulating the Potency of BRD4 PROTACs at the Systems Level with Amine-Acid Coupling Reactions

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-12-17

PREAI

Mcgrath, Andrew; Huang, Haiyan; Brazeau, Jean-Francois; Zhang, Zirong; Audu, Christopher O.; Vellore, Nadeem A.; Zhu, Lu; Shi, Zhicai; Venable, Jennifer D.; Gelin, Christine F.; Cernak, Tim

High-Throughput Assessment of Bile Salt Export Pump Inhibition Using RapidFire-MS and DESI-MS

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-08-12

PREAI

Li, Jie; Morato, Nicolas M.; Westover, Lori S.; Abeywickrema, Pravien; Geng, Jieping; Piassek, Madison; Harden, David; Strambeanu, Iulia; Shi, Zhicai; Cooks, R. Graham; Meng, Juncai

Oxoammonium Salt-Mediated On-DNA Alcohol Oxidation for DEL Synthesis

ORGANIC LETTERS

IF5

2024-07-30

PREAI

Chheda, Pratik R.; Simmons, Nicholas; Shi, Zhicai

Hydrophobic Surfactant-DNA Complex (Surf-DNA) Enables DNA-Encoded-Library-Compatible Decarboxylative Arylation under Anhydrous Conditions

ORGANIC LETTERS

IF5

2024-05-14

PREAI

Chheda, Pratik R.; Simmons, Nicholas; Shi, Zhicai

Identification of small-molecule protein-protein interaction inhibitors for NKG2D

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-04-25

OAAI

Thompson, Aaron A.; Harbut, Michael B.; Kung, Pei-Pei; Karpowich, Nathan K.; Branson, Jeffrey D.; Grant, Joanna C.; Hagan, Deborah; Pascual, Heather A.; Bai, Guoyun; Zavareh, Reza Beheshti; Coate, Heather R.; Collins, Bernard C.; Cote, Marjorie; Gelin, Christine F.; Damm-Ganamet, Kelly L.; Gholami, Hadi; Huff, Adam R.; Limon, Luis; Lum, Kevin J.; Mak, Puiying A.; Nakafuku, Kohki M.; V. Price, Edmund; Shih, Amy Y.; Tootoonchi, Mandana; Vellore, Nadeem A.; Wang, Jocelyn; Wei, Na; Ziff, Jeannie; Berger, Scott B.; Edwards, James P.; Gardet, Agnes; Sun, Siquan; Towne, Jennifer E.; Venable, Jennifer D.; Shi, Zhicai; Venkatesan, Hariharan; Rives, Marie-Laure; Sharma, Sujata; Shireman, Brock T.; Allen, Samantha J.

Global reactivity models are impactful in industrial synthesis applications (vol 15, 20, 2023)

JOURNAL OF CHEMINFORMATICS

IF5.7

2023-03-02

OAAI

Neves, Paulo; McClure, Kelly; Verhoeven, Jonas; Dyubankova, Natalia; Nugmanov, Ramil; Gedich, Andrey; Menon, Sairam; Shi, Zhicai; Wegner, Jorg K.

Global reactivity models are impactful in industrial synthesis applications

JOURNAL OF CHEMINFORMATICS

IF5.7

2023-02-11

OAAI

Neves, Paulo; McClure, Kelly; Verhoeven, Jonas; Dyubankova, Natalia; Nugmanov, Ramil; Gedich, Andrey; Menon, Sairam; Shi, Zhicai; Wegner, Jorg K.

Photoredox-Mediated Deoxygenative Alkylation of DNA-Tagged Alkenes with Activated Alcohols

ORGANIC LETTERS

IF5

2022-12-21

PREAI

Chheda, Pratik R.; Simmons, Nicholas; Schuman, David P.; Shi, Zhicai

Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2022-06-20

OAAI

Hendrick, Charles E.; Jorgensen, Jeff R.; Chaudhry, Charu; Strambeanu, Iulia I.; Brazeau, Jean-Francois; Schiffer, Jamie; Shi, Zhicai; Venable, Jennifer D.; Wolkenberg, Scott E.

Palladium-Mediated C-N Coupling of DNA-Conjugated (Hetero)aryl Halides with Aliphatic and (Hetero)aromatic Amines

ORGANIC LETTERS

IF5

2022-05-02

PREAI

Chheda, Pratik R.; Simmons, Nicholas; Schuman, David P.; Shi, Zhicai

Cholesterol-Modified Oligonucleotides as Internal Reaction Controls during DNA-Encoded Chemical Library Synthesis

BIOCONJUGATE CHEMISTRY

IF3.9

2021-03-09

PREAI

Yang, Guanyu; He, Dou; Zhu, Yijun; Zhu, Weiwei; Tan, Yang; Long, Xingwen; Wan, Jinqiao; Shi, Zhicai; Schuman, David; Chheda, Pratik; Simmons, Nicholas; Liu, Guansai

Increased building block access through collaboration

DRUG DISCOVERY TODAY

IF7.5

2018-08-01

PREAI

Helal, Christopher J.; Bartolozzi, Alessandra; Goble, Steven D.; Mania, Neelakanda S.; Guzman-Perez, Angel; Ohri, Ajay K.; Shia, Zhi-Cai; Subramanyam, Chakrapani

Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2018-05-15

109

PREAI

Yu, Younong; Zhang, Li-Kang; Buevich, Alexei, V; Li, Guoqing; Tang, Haiqun; Vachal, Petr; Colletti, Steven L.; Shi, Zhi-Cai

Profiling and Application of Photoredox C(sp3)-C(sp2) Cross-Coupling in Medicinal Chemistry

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-05-07

OAAI

Zhang, Rui; Li, Guoqing; Wismer, Michael; Vachal, Petr; Colletti, Steven L.; Shi, Zhi-Cai

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-03-16

113

PREAI

Scott, Jack D.; DeMong, Duane E.; Greshock, Thomas J.; Basu, Kallol; Dai, Xing; Harris, Joel; Hruza, Alan; Li, Sarah W.; Lin, Sue-Ing; Liu, Hong; Macala, Megan K.; Hu, Zhiyong; Mei, Hong; Zhang, Honglu; Walsh, Paul; Poirier, Marc; Shi, Zhi-Cai; Xiao, Li; Agnihotri, Gautam; Baptista, Marco A. S.; Columbus, John; Fell, Matthew J.; Hyde, Lynn A.; Kuvelkar, Reshma; Lin, Yinghui; Mirescu, Christian; Morrow, John A.; Yin, Zhizhang; Zhang, Xiaoping; Zhou, Xiaoping; Chang, Ronald K.; Embrey, Mark W.; Sanders, John M.; Tiscia, Heather E.; Drolet, Robert E.; Kern, Jonathan T.; Sur, Sylvie M.; Renger, John J.; Bilodeau, Mark T.; Kennedy, Matthew E.; Parker, Eric M.; Stamford, Andrew W.; Nargund, Ravi; McCauley, John A.; Miller, Michael W.

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-03-02

PREAI

Cernak, Tim; Gesmundo, Nathan J.; Dykstra, Kevin; Yu, Yang; Wu, Zhicai; Shi, Zhi-Cai; Vachal, Petr; Sperbeck, Donald; He, Shuwen; Murphy, Beth Ann; Sonatore, Lisa; Williams, Steven; Madeira, Maria; Verras, Andreas; Reiter, Maud; Lee, Claire Heechoon; Cuff, James; Sherer, Edward C.; Kuethe, Jeffrey; Goble, Stephen; Perrotto, Nicholas; Pinto, Shirly; Shen, Dong-Ming; Nargund, Ravi; Balkovec, James; DeVita, Robert J.; Dreher, Spencer D.

研究方向