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Guoxiang Shen

rutgers university system

H指数:31

被引数:5,379

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Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2019-02-1312

OAAI

Pharmacokinetics and Safety of Subcutaneous Pasireotide and Intramuscular Pasireotide Long-acting Release in Chinese Male Healthy Volunteers: A Phase I, Single-center, Open-label, Randomized Study

中国男性健康志愿者皮下注射和肌内注射长效释放帕瑞肽的药代动力学和安全性: I期，单中心，开放标签，随机研究

CLINICAL THERAPEUTICS

IF3.6

2014-08-0112

OAAI

Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats: Use of Radioprofiling, Modulation of Metabolism, and Adrenocortical Cell Lines to Evaluate Adrenal Toxicity

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2012-03-0216

PREAI

Site-Selective Modification of Vitamin D Analogue (Deltanoid) through a Resin-Based Version of Organoselenium 2,3-Sigmatropic Rearrangement

ORGANIC LETTERS

IF5

2010-09-0913

PREAI

Regulation of Nrf2-and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells

ACTA PHARMACOLOGICA SINICA

IF8.4

2010-08-2382

OAAI

Pharmacokinetics and Pharmacodynamics of Broccoli Sprouts on the Suppression of Prostate Cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mice: Implication of Induction of Nrf2, HO-1 and Apoptosis and the Suppression of Akt-dependent Kinase Pathway

PHARMACEUTICAL RESEARCH

IF4.3

2009-08-08109

PREAI

Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2009-02-13306

PREAI

Schroeder, Gretchen M.; An, Yongmi; Cai, Zhen-Wei; Chen, Xiao-Tao; Clark, Cheryl; Cornelius, Lyndon A. M.; Dai, Jun; Gullo-Brown, Johnni; Gupta, Ashok; Henley, Benjamin; Hunt, John T.; Jeyaseelan, Robert; Kamath, Amrita; Kim, Kyoung; Lippy, Jonathan; Lombardo, Louis J.; Manne, Veeraswamy; Oppenheimer, Simone; Sack, John S.; Schmidt, Robert J.; Shen, Guoxiang; Stefanski, Kevin; Tokarski, John S.; Trainor, George L.; Wautlet, Barri S.; Wei, Donna; Williams, David K.; Zhang, Yingru; Zhang, Yueping; Fargnoli, Joseph; Borzilleri, Robert M.

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

BIOCHEMICAL PHARMACOLOGY

IF5.6

2008-12-01714

OAAI

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

MOLECULAR CANCER THERAPEUTICS

IF5.5

2008-09-11171

OAAI

Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in APCMin/+ mouse

CANCER RESEARCH

IF16.6

2007-10-17157

OAAI

Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells

PHARMACEUTICAL RESEARCH

IF4.3

2007-07-2772

PREAI

In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice

ARCHIVES OF PHARMACAL RESEARCH

IF7.5

2006-10-0122

PREAI

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray

IF5.1

2006-10-01136

PREAI

Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice

PHARMACEUTICAL RESEARCH

IF4.3

2006-09-1362

PREAI

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

MOLECULAR CANCER THERAPEUTICS

IF5.5

2006-08-23263

OAAI

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2

CANCER RESEARCH

IF16.6

2006-08-15388

OAAI

Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells

MOLECULAR CARCINOGENESIS

IF3.2

2006-05-31131

PREAI

Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

MOLECULAR CANCER THERAPEUTICS

IF5.5

2006-01-23156

OAAI

Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice

CANCER RESEARCH

IF16.6

2006-01-19196

PREAI

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells

IF2.9

2005-11-04174

OAAI