未登录Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscapeTGFβ1激活的选择性抑制通过改变肿瘤免疫景观来克服对检查点阻断疗法的主要抵抗
Martin, Constance J.; Datta, Abhishek; Littlefield, Christopher; Kalra, Ashish; Chapron, Christopher; Wawersik, Stefan; Dagbay, Kevin B.; Brueckner, Christopher T.; Nikiforov, Anastasia; Danehy, Francis T., Jr.; Streich, Frederick C., Jr.; Boston, Christopher; Simpson, Allison; Jackson, Justin W.; Lin, Susan; Danek, Nicole; Faucette, Ryan R.; Raman, Pichai; Capili, Allan D.; Buckler, Alan; Carven, Gregory J.; Schurpf, Thomas .png)
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收藏Defeating primary checkpoint resistance: SRTβ1-Ab3 is a first-in-class, fully human antibody that renders resistant tumors sensitive to anti-PD-1Schurpf, Thomas; Martin, Constance J.; Littlefield, Christopher; Chapron, Christopher; Wawersik, Stefan; Kalra, Ashish; Simpson, Allison; Danehy, Francis; Boston, Christopher; Nikiforov, Anastasia; Lin, Susan; Jackson, Justin; Carven, Gregory J.; Buckler, Alan; Datta, Abhishek 分享 收藏 Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapyLong, Kimberly K.; O'Shea, Karen M.; Khairallah, Ramzi J.; Howell, Kelly; Paushkin, Sergey; Chen, Karen S.; Cote, Shaun M.; Webster, Micah T.; Stains, Joseph P.; Treece, Erin; Buckler, Alan; Donovan, Adriana 分享 收藏 CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signalingHenry, Kate L.; Kellner, Debra; Bajrami, Bekim; Anderson, John E.; Beyna, Mercedes; Bhisetti, Govinda; Cameron, Tom; Capacci, Andrew G.; Bertolotti-Ciarlet, Andrea; Feng, Jun; Gao, Benbo; Hopkins, Brian; Jenkins, Tracy; Li, Kejie; May-Dracka, Tricia; Murugan, Paramasivam; Wei, Ru; Zeng, Weike; Allaire, Norm; Buckler, Alan; Loh, Christine; Juhasz, Peter; Lucas, Brian; Ennis, Katelin A.; Vollman, Elisabeth; Cahir-McFarland, Ellen; Hett, Erik C.; Ols, Michelle L. 分享 收藏 Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodiesBernasconi-Elias, P.; Hu, T.; Jenkins, D.; Firestone, B.; Gans, S.; Kurth, E.; Capodieci, P.; Deplazes-Lauber, J.; Petropoulos, K.; Thiel, P.; Ponsel, D.; Choi, S. Hee; LeMotte, P.; London, A.; Goetcshkes, M.; Nolin, E.; Jones, M. D.; Slocum, K.; Kluk, M. J.; Weinstock, D. M.; Christodoulou, A.; Weinberg, O.; Jaehrling, J.; Ettenberg, S. A.; Buckler, A.; Blacklow, S. C.; Aster, J. C.; Fryer, C. J. 分享 收藏 Rescue Screens with Secreted Proteins Reveal Compensatory Potential of Receptor Tyrosine Kinases in Driving Cancer GrowthHarbinski, Fred; Craig, Vanessa J.; Sanghavi, Sneha; Jeffery, Douglas; Liu, Lijuan; Sheppard, Kelly Ann; Wagner, Sabrina; Stamm, Christelle; Buness, Andreas; Chatenay-Rivauday, Christian; Yao, Yao; He, Feng; Lu, Chris X.; Guagnano, Vito; Metz, Thomas; Finan, Peter M.; Hofmann, Francesco; Sellers, William R.; Porter, Jeffrey A.; Myer, Vic E.; Graus-Porta, Diana; Wilson, Christopher J.; Buckler, Alan; Tiedt, Ralph 分享 收藏 NVP-AUY922:: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer modelsJensen, Michael Rugaard; Schoepfer, Joseph; Radimerski, Thomas; Massey, Andrew; Guy, Chantale T.; Brueggen, Josef; Quadt, Cornelia; Buckler, Alan; Cozens, Robert; Drysdale, Martin J.; Garcia-Echeverria, Carlos; Chene, Patrick 分享 收藏 分享 收藏 Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillationsWalker, SA; Kupzig, S; Bouyoucef, D; Davies, LC; Tsuboi, T; Bivona, TG; Cozier, GE; Lockyer, PJ; Buckler, A; Rutter, GA; Allen, MJ; Philips, MR; Cullen, PJ 分享 收藏 The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascadesTugores, A; Le, J; Sorokina, I; Snijders, AJ; Duyao, M; Reddy, PS; Carlée, L; Ronshaugen, M; Mushegian, A; Watanaskul, T; Chu, S; Buckler, A; Emtage, S; McCormick, MK 分享 收藏 High prevalence of the very rare Wilson disease gene mutation Leu708Pro in the Island of Gran Canaria (Canary islands, Spain):: A genetic and clinical studyGarcía-Villarreal, L; Daniels, S; Shaw, SH; Cotton, D; Galvin, M; Geskes, J; Bauer, P; Sierra-Hernández, A; Buckler, A; Tugores, A 分享 收藏 A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohortHampe, J; Schreiber, S; Shaw, SH; Lau, KF; Bridger, S; Macpherson, AJS; Cardon, LR; Sakul, H; Harris, TJR; Buckler, A; Hall, J; Stokkers, P; van Deventer, SJH; Nürnberg, P; Mirza, MM; Lee, JCW; Lennard-Jones, JE; Mathew, CG; Curran, ME 分享 收藏 分享 收藏 分享 收藏 分享 收藏 
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