Valentine M. Macaulay - Publications, H-index & Citations

Valentine M. Macaulay

university of oxford

37H指数

131论文数

6.0K被引数

收录论文 43

发表时间

Loss of IGF-1R impairs DNA-PKcs recruitment to chromatin leading to defective end-joining IGF-1R缺失阻碍DNA-PKcs向染色质的募集，导致末端连接缺陷

Molecular Oncology

IF4.5

2026-05-07

OAAI

Matthew O. Ellis; Jack V. Mills; Wojciech Niedzwiedz; Valentine M. Macaulay

IGF-1 regulates cancer cell immune evasion in prostate cancer IGF-1调节前列腺癌中癌细胞的免疫逃逸。

Scientific Reports

IF3.9

2025-11-03

OAAI

Ashwin M. Nandakumar; Alessandro Barberis; Jinseon Kim; Cameron R. Lang; Jack V. Mills; Guillaume Rieunier; Dimitrios Doultsinos; Avigail Taylor; Ashwin Jainarayanan; Su M. Phyu; Leticia Campo; Alistair Easton; Eileen E. Parkes; Timothy James; Freddie C. Hamdy; Clare Verrill; Ian G. Mills; Valentine M. Macaulay

Detection of Genome-Wide IGF-1R Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers 检测临床前列腺癌中全基因组IGF-1R在染色质增强子和启动子区域的募集

CANCER MEDICINE

IF3.1

2025-09-30

OAAI

Mills, Jack V.; Taylor, Avigail; Singh, Reema; Kim, Jinseon; Engledow, Simon; Colling, Richard; Verrill, Clare; Mills, Ian G.; Macaulay, Valentine M.

GeneFEAST: the pivotal, gene-centric step in functional enrichment analysis interpretation GeneFEAST：功能富集分析解释中的关键基因中心步骤

BIOINFORMATICS

IF5.4

2025-03-03

OAAI

Taylor, Avigail; Macaulay, Valentine M.; Miossec, Matthieu J.; Maurya, Anand K.; Buffa, Francesca M.

A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer

BRITISH JOURNAL OF CANCER

IF6.8

2023-08-03

OAAI

Macaulay, Valentine M.; Lord, Simon; Hussain, Syed; Maroto, Jose Pablo; Jones, Robert Hugh; Climent, Miguel Angel; Cook, Natalie; Lin, Chia-Chi; Wang, Shian-Shiang; Bianchini, Diletta; Bailey, Mark; Schlieker, Laura; Bogenrieder, Thomas; de Bono, Johann

WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma

CELLULAR ONCOLOGY

IF4.8

2022-12-21

OAAI

Coupe, Nicholas; Guo, Lina; Bridges, Esther; Campo, Leticia; Espinosa, Olivia; Colling, Richard; Marshall, Andrea; Nandakumar, Ashwin; van Stiphout, Ruud; Buffa, Francesca M.; Corrie, Pippa G.; Middleton, Mark R.; Macaulay, Valentine M.

Obesity: a perfect storm for carcinogenesis 肥胖: 致癌的完美风暴

CANCER AND METASTASIS REVIEWS

IF8.7

2022-08-30

OAAI

Harris, Benjamin H. L.; Macaulay, Valentine M.; Harris, David A.; Klenerman, Paul; Karpe, Fredrik; Lord, Simon R.; Harris, Adrian L.; Buffa, Francesca M.

CHK1 inhibition exacerbates replication stress induced by IGF blockade

ONCOGENE

IF7.3

2021-11-12

OAAI

Wu, Xiaoning; Seraia, Elena; Hatch, Stephanie B.; Wan, Xiao; Ebner, Daniel V.; Aroldi, Francesca; Jiang, Yanyan; Ryan, Anderson J.; Bogenrieder, Thomas; Weyer-Czernilofsky, Ulrike; Rieunier, Guillaume; Macaulay, Valentine M.

Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction

CANCER RESEARCH

IF16.6

2021-01-28

OAAI

Rieunier, Guillaume; Wu, Xiaoning; Harris, Letitia E.; Mills, Jack, V; Nandakumar, Ashwin; Colling, Laura; Seraia, Elena; Hatch, Stephanie B.; Ebner, Daniel, V; Folkes, Lisa K.; Weyer-Czernilofsky, Ulrike; Bogenrieder, Thomas; Ryan, Anderson J.; Macaulay, Valentine M.

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

BRITISH JOURNAL OF CANCER

IF6.8

2019-12-20

OAAI

Simpson, Aaron D.; Soo, Ying Wei Jenetta; Rieunier, Guillaume; Aleksic, Tamara; Ansorge, Olaf; Jones, Chris; Macaulay, Valentine M.

Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma

BRITISH JOURNAL OF CANCER

IF6.8

2019-12-16

OAAI

Gupta, Avinash; Towers, Christopher; Willenbrock, Frances; Brant, Roz; Hodgson, Darren Richard; Sharpe, Alan; Smith, Paul; Cutts, Anthony; Schuh, Anna; Asher, Ruth; Myers, Kevin; Love, Sharon; Collins, Linda; Wise, Adelyn; Middleton, Mark Roy; Macaulay, Valentine Moya

Therapeutic Targeting of the IGF Axis

CELLS

IF5.2

2019-08-14

125

OAAI

Osher, Eliot; Macaulay, Valentine M.

Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage

CANCER RESEARCH

IF16.6

2018-07-01

OAAI

Aleksic, Tamara; Gray, Nicki; Wu, Xiaoning; Rieunier, Guillaume; Osher, Eliot; Mills, Jack; Verrill, Clare; Bryant, Richard J.; Han, Cheng; Hutchinson, Kathryn; Lambert, Adam G.; Kumar, Rajeev; Hamdy, Freddie C.; Weyer-Czernilofsky, Ulrike; Sanderson, Michael P.; Bogenrieder, Thomas; Taylor, Stephen; Macaulay, Valentine M.

IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer

BRITISH JOURNAL OF CANCER

IF6.8

2017-10-03

OAAI

Aleksic, Tamara; Verrill, Clare; Bryant, Richard J.; Han, Cheng; Worrall, Andrew Ross; Brureau, Laurent; Larre, Stephane; Higgins, Geoff S.; Fazal, Fahad; Sabbagh, Ahmad; Haider, Syed; Buffa, Francesca M.; Cole, David; Macaulay, Valentine M.

Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies

TARGETED ONCOLOGY

IF4

2017-08-16

135

OAAI

Simpson, Aaron; Petnga, Wilfride; Macaulay, Valentine M.; Weyer-Czernilofsky, Ulrike; Bogenrieder, Thomas

TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy TOPK调节肿瘤特异性放射敏感性并与前列腺放疗后复发相关

BRITISH JOURNAL OF CANCER

IF6.8

2017-07-04

OAAI

Pirovano, Giacomo; Ashton, Thomas M.; Herbert, Katharine J.; Bryant, Richard J.; Verrill, Clare L.; Cerundolo, Lucia; Buffa, Francesca M.; Prevo, Remko; Harrap, Iona; Ryan, Anderson J.; Macaulay, Valentine; McKenna, William G.; Higgins, Geoff S.

Durable Response of spinal Chordoma to Combined Inhibition of IGF-1R and EGFR

FRONTIERS IN ONCOLOGY

IF3.3

2016-05-02

OAAI

Aleksic, Tamara; Browning, Lisa; Woodward, Martha; Phillips, Rachel; Page, Suzanne; Henderson, Shirley; Athanasou, Nicholas; Ansorge, Olaf; Whitwell, Duncan; Pratap, Sarah; Hassan, A. Bassim; Middleton, Mark R.; Macaulay, Valentine M.

Raptor upregulation contributes to maintenance of 4EBP1 phosphorylation and TORC kinase resistance in renal cancer cells

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Earwaker, Philip; Willenbrock, Frances; Protheroe, Andrew; Macaulay, Valentine

IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer

CARCINOGENESIS

IF2.9

2015-04-20

OAAI

Dale, Oliver T.; Aleksic, Tamara; Shah, Ketan A.; Han, Cheng; Mehanna, Hisham; Rapozo, Davy C. M.; Sheard, Jon D. H.; Goodyear, Paul; Upile, Navdeep S.; Robinson, Max; Jones, Terence M.; Winter, Stuart; Macaulay, Valentine M.

Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition

INTERNATIONAL JOURNAL OF CANCER

IF4.7

2014-11-25

OAAI

Lodhia, Kunal A.; Gao, Shan; Aleksic, Tamara; Esashi, Fumiko; Macaulay, Valentine M.

研究方向